3D printing of tubular scaffolds with elasticity and complex structure from multiple waterborne polyurethanes for tracheal tissue engineering

Hsieh, Cheng‐Tien; Liao, Chao Yaug; Dai, Niann Tzyy; Tseng, Ching-Shiow; Yen, B. Linju; Hsu, Shan‐hui

doi:10.1016/j.apmt.2018.06.004

Cited by 41 publications

(34 citation statements)

References 40 publications

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“…in vitro studies revealed that the scaffold enhances the differentiation of MSCs, along with secretion of neo‐ECM rich in glycosaminoglycans and collagen to regenerated cartilaginous tissue. In nude mice model, the subcutaneous implantation of recellularized tracheal scaffold has similar compression modulus and contraction as to the native tracheal tissue, which indicates the potential application of the graft (Hsieh et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

“…Hsieh et al () designed the biodegradable 3D tubular scaffold by using bioink, which consists of elastomeric water‐based PUs and bioactive factor/drug. in vitro studies revealed that the scaffold enhances the differentiation of MSCs, along with secretion of neo‐ECM rich in glycosaminoglycans and collagen to regenerated cartilaginous tissue.…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

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Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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“…This strategy resulted in ~500 μm-diameter strands with notably enhanced cell density, also increased post-transplantation maturation and function of the printed tissue [205]. Combining varied cell types may also improve the effectiveness of the engineered cartilage [206]. In a research reported by Levato et al [207], three materials were loaded for printing via multi-dispenser heads: (1) a superficial zone-mimicking bioink, consisting of articular cartilage-resident chondroprogenitor cell (ACPC)-laden GelMA, (2) a middle/deep zone-mimicking bioink, composed of bone marrow mesenchymal stromal cell (MSC)-laden GelMA, and (3) pluronic F-127 as sacrificial ink to support (MSC)laden GelMA during the process.…”

Section: Cartilagementioning

confidence: 99%

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

et al. 2021

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“…Jae Yeon Lee et al developed an artificial tracheal structure PCL framework by extrusion bioprinting and silicone band by direct bioprinting and rod-supporting bioprinting ( Figure 5) [150]. In particular, the states of the PCL extrusion were precisely controlled to create dotted circular patterns so that the bellows framework had about 300 µm pores in the wall except for groove parts.…”

Section: Tracheamentioning

confidence: 99%

“… Structural images of the tracheal tubular structure by direct and rod-supporting bioprinting [ 150 ]. …”

Section: Figurementioning

confidence: 99%

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

et al. 2020

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It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.

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3D printing of tubular scaffolds with elasticity and complex structure from multiple waterborne polyurethanes for tracheal tissue engineering

Cited by 41 publications

References 40 publications

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

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