3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

Nizioł, Martyna; Paleczny, Justyna; Junka, Adam; Shavandi, Amin; Dawiec‐Liśniewska, Anna; Podstawczyk, Daria

doi:10.3390/bioengineering8060079

Cited by 47 publications

(39 citation statements)

References 65 publications

(82 reference statements)

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“…The swelling hydrogel and drug release profiles were dependent on the temperature. The highest the temperature, the lowest the swelling ratio and the highest the OCT release [148].…”

Section: Drugsmentioning

confidence: 98%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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“…The swelling hydrogel and drug release profiles were dependent on the temperature. The highest the temperature, the lowest the swelling ratio and the highest the OCT release [148].…”

Section: Drugsmentioning

confidence: 98%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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“…Recently, PNIPAA was co-polymerized with alginate (ALG) and methylcellulose. The gel precursor was 3D printed to develop wound dressings [ 202 ]. The wound dressing was loaded with Octenisept ® , to provide antimicrobial properties.…”

Section: D Printed Wound Dressing Integrated With Sensorsmentioning

confidence: 99%

“… ( a ) Synthesis of the quaternized chitosan (QCS), ( b ) synthesis of the reduction graphene oxide coated by polydopamine (rGO-PDA), ( c ) schematic for the preparation process of the QCS/rGO-PDA/PNIPAm hydrogel and its properties: (1) conductivity, (2) tissue adhesion, (3) antibacterial activity, (4) self-healing, and (5) thermo-responsive self-contraction. ( d ) schematic showing the wound closure by assisting the thermos-responsive hydrogel (QCS/rGO-PDA/PNIPAm) [ 202 ]. …”

Section: Figurementioning

confidence: 99%

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

2022

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Wounds are a major health concern affecting the lives of millions of people. Some wounds may pass a threshold diameter to become unrecoverable by themselves. These wounds become chronic and may even lead to mortality. Recently, 3D printing technology, in association with biocompatible hydrogels, has emerged as a promising platform for developing smart wound dressings, overcoming several challenges. 3D printed wound dressings can be loaded with a variety of items, such as antibiotics, antibacterial nanoparticles, and other drugs that can accelerate wound healing rate. 3D printing is computerized, allowing each level of the printed part to be fully controlled in situ to produce the dressings desired. In this review, recent developments in hydrogel-based wound dressings made using 3D printing are covered. The most common biosensors integrated with 3D printed hydrogels for wound dressing applications are comprehensively discussed. Fundamental challenges for 3D printing and future prospects are highlighted. Additionally, some related nanomaterial-based hydrogels are recommended for future consideration.

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“…Polycaprolactone dimethacrylate with 2-ureido-4[1H]-pyrimidinone motifs has been utilized to achieve the scaffold. Further studies on cell adhesion and proliferation can be performed to explore it for application in wound healing [119].…”

Section: Nanoparticles In Self-healing Hydrogels For Wound Healingmentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

Cited by 47 publications

References 65 publications

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

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