3D printing of resorbable poly(propylene fumarate) tissue engineering scaffolds

Childers, Erin P.; Wang, Martha O.; Becker, Matthew L.; Fisher, John P.; Dean, David

doi:10.1557/mrs.2015.2

Cited by 72 publications

(78 citation statements)

References 77 publications

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“…PPF is a bioresorbable and photocrosslinkable polyester [1] and was synthesized via a chain-growth mechanism [32,33]. To reduce the viscosity for 3D printing, PPF (M n = 1500 Da, PDI = 1.6) was diluted with diethyl fumarate (DEF, Sigma-Aldrich, St. Louis, MO) in a 1:1 ratio.…”

Section: Resin Formulationmentioning

confidence: 99%

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Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

et al. 2017

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Section: Resin Formulationmentioning

confidence: 99%

“…Tissue engineering (TE) is a rapidly evolving biotechnology field that aims to reconstruct and regenerate tissue lost to trauma or disease [1]. One of the most important aspects of TE is the design and fabrication of the scaffold [2].…”

Section: Introductionmentioning

confidence: 99%

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

et al. 2017

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“…However, bioprinting requires deposition of multiple layers with registration. 141 Additionally, cells must survive potential shear forces encountered during the printing process. Finally, laser sintering uses a laser, rastered across the sample, to locally heat powered ceramics, metals, and polymers to their melting temperature to yield the final scaffold.…”

Section: Three-dimensional Printed Constructs For Bone Tissue Engineementioning

confidence: 99%

“…Finally, laser sintering uses a laser, rastered across the sample, to locally heat powered ceramics, metals, and polymers to their melting temperature to yield the final scaffold. 141 Laser sintering is generally used in a layer-by-layer assembly approach and may require multiple passes. In addition, resolution is significantly lower than that of stereolithography.…”

Section: Three-dimensional Printed Constructs For Bone Tissue Engineementioning

confidence: 99%

Hydrogels that allow and facilitate bone repair, remodeling, and regeneration

et al. 2015

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Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current “gold standard” treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock. There is thus a critical need for the development of new, engineered materials for bone repair. This review describes the use of natural and synthetic hydrogels as scaffolds for bone tissue engineering. We discuss many of the advantages that hydrogels offer as bone repair materials, including their potential for osteoconductivity, biodegradability, controlled growth factor release, and cell encapsulation. We also discuss the use of hydrogels in composite devices with metals, ceramics, or polymers. These composites are useful because of the low mechanical moduli of hydrogels. Finally, the potential for thermosetting and photo-cross-linked hydrogels as three-dimensionally (3D) printed, patient-specific devices is highlighted. Three-dimensional printing enables controlled spatial distribution of scaffold materials, cells, and growth factors. Hydrogels, especially natural hydrogels present in bone matrix, have great potential to augment existing bone tissue engineering devices for the treatment of critical size bone defects.

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“…Surface chemistry and texturing of these biomaterials can greatly influence cellular behaviors and interactions such as adhesion, migration, orientation, differentiation, proliferation, protein synthesis, and segregation [2]. In particular, periodically patterned structures made of biopolymers and ceramics have been enabling diverse biomedical applications as novel templates or scaffolds for bone and tissue culture [3]. For example, bio-inspired smart periodic multi-scale structures, such as nanorods-on-arrayed micro-pillars [4], can exhibit super-wettability or extreme hydrophobicity.…”

Section: Introductionmentioning

confidence: 99%

Transfer molding processes for nanoscale patterning of poly-L-lactic acid (PLLA) films

et al. 2016

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Nanoscale patterned structures composed of biomaterials exhibit great potential for the fabrication of functional biostructures. In this paper, we report cost-effective, rapid, and highly reproducible soft lithographic transfer-molding techniques for creating periodic micro-and nano-scale textures on poly (L-lactic acid) (PLLA) surface. These artificial textures can increase the overall surface area and change the release dynamics of the therapeutic agents coated on it. Specifically, we use the double replication technique in which the master pattern is first transferred to the PDMS mold and the pattern on PDMS is then transferred to the PLLA films through drop-casting as well as nano-imprinting. The ensuing comparison studies reveal that the drop-cast PLLA allows pattern transfer at higher levels of fidelity, enabling the realization of nano-hole and nano-cone arrays with pitch down to ~700 nm. The nano-patterned PLLA film was then coated with rapamycin to make it drug-eluting.

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3D printing of resorbable poly(propylene fumarate) tissue engineering scaffolds

Abstract: Abstract

Cited by 72 publications

References 77 publications

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

Hydrogels that allow and facilitate bone repair, remodeling, and regeneration

Transfer molding processes for nanoscale patterning of poly-L-lactic acid (PLLA) films

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