3D Printing of Conductive Tissue Engineering Scaffolds Containing Polypyrrole Nanoparticles with Different Morphologies and Concentrations

Ma, Chunyang; Jiang, Le; Wang, Yingjin; Gang, Fangli; Xu, Nan; Li, Ting; Liu, Zhongqun; Chi, Yongjie; Wang, Xiumei; Zhao, Lingyun; Feng, Qingling; Sun, Xiaodan

doi:10.3390/ma12152491

Cited by 37 publications

(31 citation statements)

References 34 publications

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“…The application of novel methodologies in nanotechnology such as 3-D fiber deposition and electro-spinning has led to the enhancement of nanoscaffold quality [45]. Also, the integration of nanoparticles into biomaterials has been shown as a beneficial technique that mimics the ECM and provides the interaction of the cells with the scaffolds, resulting in more functionalized tissue engineering constructs [46].…”

Section: Nanomaterials For Cartilage Tissue Engineeringmentioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

100

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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Section: Nanomaterials For Cartilage Tissue Engineeringmentioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

100

View full text Add to dashboard Cite

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“…Biocompatible and biodegradable nanoparticles (NPs) continue to be extensively investigated for the diagnosis, prevention, and therapy of various diseases, for cellular and molecular imaging, and for tissue engineering applications [1,2,3,4,5]. NPs have been reported to target various therapeutic agents to the central nervous system (CNS), tumour sites, and the vascular compartment [6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Size and Concentration of PLGA-PEG Nanoparticles on Activation and Aggregation of Washed Human Platelets

et al. 2019

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Nanotechnology is being increasingly utilised in medicine as diagnostics and for drug delivery and targeting. The small size and high surface area of nanoparticles (NPs), desirable properties that allow them to cross biological barriers, also offer potential for interaction with other cells and blood constituents, presenting possible safety risks. While NPs investigated are predominantly based on the biodegradable, biocompatible, and FDA approved poly-lactide-co-glycolide (PLGA) polymers, pro-aggregatory and antiplatelet effects have been reported for certain NPs. The potential for toxicity of PLGA based NPs remains to be examined. The aims of this study were to determine the impact of size-selected PLGA-PEG (PLGA-polyethylene glycol) NPs on platelet activation and aggregation. PLGA-PEG NPs of three average sizes of 112, 348, and 576 nm were formulated and their effect at concentrations of 0.0–2.2 mg/mL on the activation and aggregation of washed human platelets (WP) was examined. The results of this study show, for the first time, NPs of all sizes associated with the surface of platelets, with >50% binding, leading to possible internalisation. The NP-platelet interaction, however, did not lead to platelet aggregation nor inhibited aggregation of platelets induced by thrombin. The outcome of this study is promising, suggesting that these NPs could be potential carriers for targeted drug delivery to platelets.

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“…The biological properties of bioactive materials are determined by their structure and physicochemical properties [ [10] , [11] , [12] ]. Good biocompatibility is a prerequisite for the use of biomaterials [ [13] , [14] , [15] , [16] ]. The detection of cell activity is an important criterion for judging whether cells can grow normally when they interact with the biomaterials both in vitro and in vivo [ [17] , [18] , [19] ].…”

Section: Introductionmentioning

confidence: 99%

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Jiang

Liu

Wang

et al. 2021

Bioactive Materials

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The fate of mesenchymal stem cells (MSCs) is regulated by biological, physical and chemical signals. Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their fate. In order to design and synthesize materials that can precisely regulate the fate of MSCs, the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified, in which the detection of the fate of mesenchymal stem cells plays an important role. In the past 30 years, a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials, among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one time. In this review, the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials (BBMs) are systematically reviewed from traditional technology to high-throughput technology which is emphasized especially. Moreover, current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected. The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs, so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs.

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3D Printing of Conductive Tissue Engineering Scaffolds Containing Polypyrrole Nanoparticles with Different Morphologies and Concentrations

Cited by 37 publications

References 34 publications

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Effect of Size and Concentration of PLGA-PEG Nanoparticles on Activation and Aggregation of Washed Human Platelets

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

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