3D printing multiphasic osteochondral tissue constructs with nano to micro features via PCL based bioink

Nowicki, Margaret; Zhu, Wei; Sarkar, Kausik; Rao, Raj D.; Zhang, Lijie Grace

doi:10.1016/j.bprint.2019.e00066

Cited by 31 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The melting point and glass‐transition temperature of the PCL is 63 and 60 °C, respectively. [ 104–106 ] Nowicki et al [ 107 ] utilized the integration of 3D bioprinted, fused deposition modeling with PCL‐based biomaterial as to fabricate osteochondral tissue. For this to occur, multiphase structures were designed with different layer geometries.…”

Section: Hydrogel‐based Bioinksmentioning

confidence: 99%

Natural and Synthetic Bioinks for 3D Bioprinting

Khoeini

Nosrati

Akbarzadeh

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Bioprinting offers tremendous potential in the fabrication of functional tissue constructs for replacement of damaged or diseased tissues. Among other fabrication methods used in tissue engineering, bioprinting provides accurate control over the construct's geometric and compositional attributes using an automated approach. Bioinks are composed of the hydrogel material and living cells that are critical process variables in the fabrication of functional, mechanically robust constructs. Appropriate cells can be encapsulated in bioinks to create functional tissue structures. Ideal bioinks are required to undergo a sol–gel transition consuming minimal processing time, and a plethora of chemical and physical crosslinking mechanisms are generally exploited to achieve high shape fidelity and construct stability. In contrast, crosslinking of hydrogel material at rapid rates can cause nozzle clogging, and hence, optimization of the bioink is often necessary. Bioinks can be formulated using natural or synthetic biomaterials, alone or in combination of these biomaterials. Herein, the various bioprinting methods are discussed; the natural, synthetic, or hybrid materials used as bioinks are analyzed; and the challenges, limitations, and future directions concerning the bioprinting technique are appraised.

show abstract

Section: Hydrogel‐based Bioinksmentioning

confidence: 99%

Natural and Synthetic Bioinks for 3D Bioprinting

Khoeini

Nosrati

Akbarzadeh

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

show abstract

“…Although 3D printing technology has a huge advantage over traditional technology, traditional technology is not useless. For instance, scientists used innovative bio-inks to combine FDM technology with casting technology to create new types of osteochondral tissue constructs, producing the scaffolds with excellent mechanical properties and enhanced adhesion, growth, and differentiation of hMSCs [ 55 ].…”

Section: Multi-technology Joint Manufacturingmentioning

confidence: 99%

“… [ 38 ] PDA + TGF-β1 PCL FDM Improved biological performance. [ 55 ] SDF-1α Titanium SLS Attracted significantly more stem cells. [ 88 ] copper-loaded- ZIF-8 nanoparticles PLGA 3D Bio-plotting The mMSCs cultured well-spread and adherent with a high proliferation rate.…”

Section: Scaffold Modification After Printingmentioning

confidence: 99%

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Wang

Guo

2021

Regenerative Therapy

107

View full text Add to dashboard Cite

Due to traffic accidents, injuries, burns, congenital malformations and other reasons, a large number of patients with tissue or organ defects need urgent treatment every year. The shortage of donors, graft rejection and other problems cause a deficient supply for organ and tissue replacement, repair and regeneration of patients, so regenerative medicine came into being. Stem cell therapy plays an important role in the field of regenerative medicine, but it is difficult to fill large tissue defects by injection alone. The scientists combine three-dimensional (3D) printed bone tissue engineering scaffolds with stem cells to achieve the desired effect. These scaffolds can mimic the extracellular matrix (ECM), bone and cartilage, and eventually form functional tissues or organs by providing structural support and promoting attachment, proliferation and differentiation. This paper mainly discussed the applications of 3D printed bone tissue engineering scaffolds in stem cell regenerative medicine. The application examples of different 3D printing technologies and different raw materials are introduced and compared. Then we discuss the superiority of 3D printing technology over traditional methods, put forward some problems and limitations, and look forward to the future.

show abstract

“…Recently, Nowicki et al [ 140 ] developed a new multiphase scaffold, with different layer geometries and by FFF, to improve the functions of human MSCs from bone marrow (hMSC). They were the first to use a PCL-based form memory material, composed of: PCL-triol, castor oil, and poly(hexamethylene diisocyanate), as osteochondral matrix material.…”

Section: Strategies For Osteochondral Regenerationmentioning

confidence: 99%

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço

Fernandes

Lattanzi

2021

JFB

View full text Add to dashboard Cite

Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondral fissure extending until the subchondral bone (corresponding to a IV grade according to the conventional radiographic classification by Berndt and Harty). Therefore, strategies for functional tissue regeneration should also aim at healing the subchondral bone and joint interface, besides hyaline cartilage. With the ambition of contributing to solving this problem, several research groups have been working intensively on the development of tailored implants that could promote that complex osteochondral regeneration. These implants may be manufactured through a wide variety of processes and use a wide variety of (bio)materials. This review aimed to examine the state of the art regarding the challenges, advantages, and drawbacks of the current strategies for osteochondral regeneration. One of the most promising approaches relies on the principles of additive manufacturing, where technologies are used that allow for the production of complex 3D structures with a high level of control, intended and predefined geometry, size, and interconnected pores, in a reproducible way. However, not all materials are suitable for these processes, and their features should be examined, targeting a successful regeneration.

show abstract

3D printing multiphasic osteochondral tissue constructs with nano to micro features via PCL based bioink

Cited by 31 publications

References 20 publications

Natural and Synthetic Bioinks for 3D Bioprinting

Natural and Synthetic Bioinks for 3D Bioprinting

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Contact Info

Product

Resources

About