3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

Zhong, Weiyang; Li, Jianxiao; Hu, Chenbo; Quan, Zhengxue; Jiang, Dianming; Huang, Guangbin; Wang, Zhigang

doi:10.1186/s13018-020-01593-x

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…The evaluation of osteogenesis in vivo revealed that the PDA-coated scaffold had a higher osteogenic potential; indeed, significant new bone formation was observed from week 2 to week 6, with the highest density observed for PDA2 groups (Figure 16). Similar results in terms of in vivo osteogenesis have been obtained employing PDA-coated titanium implants [145].…”

Section: D Printed Scaffoldssupporting

confidence: 81%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

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Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant role in photoprotection as well as in many biological functions ensuring homeostasis. Due to their broad-spectrum light absorption, radical scavenging, electric conductivity, and paramagnetic behavior, eumelanins are widely studied in the biomedical field. The continuing advancements in the development of biomimetic design strategies offer novel opportunities toward specifically engineered multifunctional biomaterials for regenerative medicine. Melanin and melanin-like coatings have been shown to increase cell attachment and proliferation on different substrates and to promote and ameliorate skin, bone, and nerve defect healing in several in vivo models. Herein, the state of the art and future perspectives of melanins as promising bioinspired platforms for natural regeneration processes are highlighted and discussed.

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Section: D Printed Scaffoldssupporting

confidence: 81%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

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“…Of course, important findings such as this were not exclusive to the most frequently reported outcome measures. Less common measures including bone composition analysis 60 and trabecular thickness and number 43,52,53 should be noted for their usefulness in providing insights into the quality of bone resulting from 3DP pTi and other biomaterials.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers further explored HA in the form of composites, with studies reporting improved bone ingrowth for HA doped with magnesium, 49 polydopamine, 45 silicon, 59 or strontium 59 compared to uncoated controls, though the silicon and strontium groups did not show the same improvement when compared to undoped HA coatings 59 . Aside from HA, polydopamine coatings, 48,52 titanium copper and titanium copper nitride films, 37 growth factor‐doped fibrin glue, 51 and strontium‐laden nanotube coatings 55 also showed success in increasing 3DP pTi bioactivity. Instead of coatings, one study by Li et al used surface heat treatments to induce material phase transformations, 53 reporting that samples treated at 950 and 1000°C were associated with higher rates of bone formation, thicker bone trabeculae, and greater push‐out loads 53 .…”

Section: Discussionmentioning

confidence: 99%

A systematic review of preclinical in vivo testing of 3D printed porous Ti6Al4V for orthopedic applications, part I: Animal models and bone ingrowth outcome measures

et al. 2021

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For Ti6Al4V orthopedic and spinal implants, osseointegration is often achieved using complex porous geometries created via additive manufacturing (AM). While AM porous titanium (pTi) has shown clinical success, concerns regarding metallic implants have spurred interest in alternative AM biomaterials for osseointegration. Insights regarding the evaluation of these new materials may be supported by better understanding the role of preclinical testing for AM pTi. We therefore asked: (a) What animal models have been most commonly used to evaluate AM porous Ti6Al4V for orthopedic bone ingrowth; (b) What were the primary reported quantitative outcome measures for these models; and (c) What were the bone ingrowth outcomes associated with the most frequently used models? We performed a systematic literature search and identified 58 articles meeting our inclusion criteria. We found that AM pTi was evaluated most often using rabbit and sheep femoral condyle defect (FCD) models. Additional ingrowth models including transcortical and segmental defects, spinal fusions, and calvarial defects were also used with various animals based on the study goals. Quantitative outcome measures determined via histomorphometry including ''bone ingrowth'' (range: 3.92–53.4% for rabbit/sheep FCD) and bone‐implant contact (range: 9.9–59.7% for rabbit/sheep FCD) were the most common. Studies also used 3D imaging to report outcomes such as bone volume fraction (BV/TV, range: 4.4–61.1% for rabbit/sheep FCD), and push‐out testing for outcomes such as maximum removal force (range: 46.6–3092 N for rabbit/sheep FCD). Though there were many commonalities among the study methods, we also found significant heterogeneity in the outcome terms and definitions. The considerable diversity in testing and reporting may no longer be necessary considering the reported success of AM pTi across all model types and the ample literature supporting the rabbit and sheep as suitable small and large animal models, respectively. Ultimately, more standardized animal models and reporting of bone ingrowth for porous AM materials will be useful for future studies.

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“…Mas, segundo Zhong et al (2020), o implante de titânio poroso possui baixa bioatividade. Logo, existe a possibilidade de a placa ser revestida com polidopamina, um polímero resultante da oxidação da dopamina, aumentando a biointegração entre implante e osso, diminuindo as chances de rejeição do organismo ao protótipo.…”

Section: Placas De Titânio Poroso Customizadaunclassified

Prototipagem rápida na medicina veterinária: Revisão

Silva¹,

Santos²

2022

Pubvet

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A prototipagem rápida é realizada em impressoras em três dimensões (3D), que utilizam vários materiais, como nylon, metal ou células de tecidos, viabilizando a produção de objetos de diversas formas e tamanhos. Para isto, ela trabalha a partir de uma imagem virtual do objeto desejado. Esta tecnologia traz diversas possibilidades na medicina veterinária, como a fabricação de modelos anatômicos fidedignos, placas, próteses e guias de broca customizados para o paciente, contribuindo para a capacitação de estudantes de graduação e residentes, além de aumentar a confiança do cirurgião, por possibilitar o planejamento e treinos prévios aos procedimentos, aumentando sua precisão cirúrgica e reduzindo o tempo do procedimento e o número de lesões iatrogênicas causadas em estruturas adjacentes à área de interesse. Além disso, os protótipos podem contribuir para a reabilitação de pacientes traumatizados ou mutilados, como aves, quelônios e outros animais silvestres. Mas seu custo relativamente alto, e a falta de profissionais capacitados para sua elaboração ainda limitam seu uso, porém a redução no tempo que propicia na execução de tratamentos pode compensar seu investimento.

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3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

Cited by 12 publications

References 20 publications

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

A systematic review of preclinical in vivo testing of 3D printed porous Ti6Al4V for orthopedic applications, part I: Animal models and bone ingrowth outcome measures

Prototipagem rápida na medicina veterinária: Revisão

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