3D printed scaffolds of alginate/polyvinylalcohol with silk fibroin based on mimicked extracellular matrix for bone tissue engineering in maxillofacial surgery

Sangkert, Supaporn; Kamolmatyakul, Suttatip; Gelinsky, Michael; Meesane, Jirut

doi:10.1016/j.mtcomm.2021.102140

Cited by 26 publications

(8 citation statements)

References 36 publications

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“…The fiber diameter was estimated as 820 μm � 103 μm, 818 μm � 93 μm, 787 μm � 83 μm, and 740 μm � 88 μm, and pore size as 686 μm � 88 μm, 659 μm � 108 μm, 633 � 121 μm, and 527 μm � 80 μm with sodium alginate/silk fibroin: 90/10, 80/20, 70/30 and 60/40 respectively. Furthermore, the fiber formation was uniformly consistent with viscosity as the silk fibroin content was increased [36].…”

Section: Morphological Analysismentioning

confidence: 62%

Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

Majhi,

Pramanik

2023

Materialwissenschaft Werkst

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Tissue engineering is a method that involves incorporating cells using scaffold elements and growth factors to support the development or replacement of worn tissue and organs. Scaffolds, with proper form and dimension, along with natural physical and chemical features, are continually in need of improving performance and repairing damaged tissue. In this work, microfibrous three‐dimensional scaffolds composed of sodium alginate and silk fibroin natural polymers are reported. Sodium alginate/silk fibroin scaffolds were fabricated by three‐dimensional printing technique using aqueous sodium alginate/silk fibroin blends with weight ratios of 60/40, 70/30, 80/20, and 90/10. Sodium alginate/silk fibroin: (70/30) exhibited regulated swelling and degradation, responses with a tensile strength of 0.75±0.013 MPa. All the scaffolds had shown protein adsorption over 350 μg exhibiting their suitability as substrates for cell adhesion. The fabricated sodium alginate/silk fibroin scaffolds are hydrophilic and biocompatible as apparent from the contact angle, protein adsorption, 3‐[4, 5‐dimethylthiazole‐2‐yl]‐2, 5‐diphenyltetrazolium bromide (MTT) assay, and cell attachment studies. In vitro‐biomineralization study showed higher apatite layer deposition ability of the sodium alginate/silk fibroin: 70/30 scaffold. The result suggests that sodium alginate/silk fibroin: 70/30 scaffold might be used as a potential platform for tissue engineering application.

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Section: Morphological Analysismentioning

confidence: 62%

Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

Majhi,

Pramanik

2023

Materialwissenschaft Werkst

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“…Briefly, the scaffold was weighed and placed separately in 10 mL of each medium at 37 ± 0.5 • C. At specific intervals, the scaffold was removed from the swelling medium, and the excess medium was carefully removed with filter paper and weighed. The swelling ratio was calculated using the following equation [29]:…”

Section: Swelling and Degradation Studiesmentioning

confidence: 99%

Maillard Reaction Crosslinked Alginate-Albumin Scaffolds for Enhanced Fenofibrate Delivery to the Retina: A Promising Strategy to Treat RPE-Related Dysfunction

et al. 2023

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There are limited treatments currently available for retinal diseases such as age-related macular degeneration (AMD). Cell-based therapy holds great promise in treating these degenerative diseases. Three-dimensional (3D) polymeric scaffolds have gained attention for tissue restoration by mimicking the native extracellular matrix (ECM). The scaffolds can deliver therapeutic agents to the retina, potentially overcoming current treatment limitations and minimizing secondary complications. In the present study, 3D scaffolds made up of alginate and bovine serum albumin (BSA) containing fenofibrate (FNB) were prepared by freeze-drying technique. The incorporation of BSA enhanced the scaffold porosity due to its foamability, and the Maillard reaction increased crosslinking degree between ALG with BSA resulting in a robust scaffold with thicker pore walls with a compression modulus of 13.08 KPa suitable for retinal regeneration. Compared with ALG and ALG-BSA physical mixture scaffolds, ALG-BSA conjugated scaffolds had higher FNB loading capacity, slower release of FNB in the simulated vitreous humour and less swelling in water and buffers, and better cell viability and distribution when tested with ARPE-19 cells. These results suggest that ALG-BSA MR conjugate scaffolds may be a promising option for implantable scaffolds for drug delivery and retinal disease treatment.

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“…78,79 Personalized dosing allows adjusting the delivery of drugs according to the patients' quality and metabolism. For example, the personalized drug delivery platform constructed by 3D printing technology can realize the Alginate-HA Tissue engineering; wound dressing [52,53] Polysaccharide-polypeptide/protein Chitosan-collagen Tissue engineering [54,55] Alginate-collagen Cartilage tissue engineering [56] Alginate-Gelatin Muscle engineering; endometrial repair [57,58] Glycosaminoglycan-polypeptide/protein HA−collagen Osteogenic differentiation [59] HA-gelatin Transplanted stem cells, brain injury repair [60] Polypeptide/protein-polypeptide/protein Collagen-Gelatin Prevascularized tissue replacement [61] Gelatin-silk Cell delivery; tissue engineering [62] Gelatin−elastin Reduces inflammation and scar tissue formation [63] Natural-synthetic Polysaccharide-synthetic Chitosan-PVA Drug delivery, tissue regeneration [64] Alginate-PVA Tissue engineering and medical applications [65,66] Alginate-PAAm Bio-medical applications [67] Glycosaminoglycan-synthetic HA-PVA Drug delivery, 3D culture of cells [68] Polypeptide/protein-synthetic Gelatin-Polyurethane Cell print; cartilage formation [69] Gelatin-PEGDA Wound healing, dexamethasone delivery [70] Synthetic-synthetic PVA-PAA Delivery sodium indomethacin [71] PEDOT-PSS Encapsulate cells [72] manufacturing of trace drugs to meet the needs of growing children. 74,80 In addition, through personalized customization and stable manufacturing in small batches, 3D printing technology also effectively promotes the development of local drug delivery.…”

Section: Personalizationmentioning

confidence: 99%

Recent advances in 3D printing hydrogel for topical drug delivery

Zhang

Wang

2022

MedComm – Biomaterials and Applications

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Polymer hydrogel has been used as a drug delivery carrier for many decades. Recently, the emergence of three‐dimensional (3D) printing technology has opened up a new area for applications of drug delivery based on polymer hydrogel. A series of drug delivery platforms based on 3D printing hydrogel are developed to achieve local delivery of small/large molecule drugs as well as therapeutic cells. Compared with other manufacturing technologies, 3D printing technology can achieve high‐precision personalized manufacturing and complex spatial structure construction, which has a wide application prospect in the biomedical field. In this review, we summarized the recent advances in 3D printed polymer hydrogels as delivery platforms in drug and cell topical delivery. 3D printed drug delivery platform realizes drug delivery and controlled release locally. Meanwhile, precise control and manufacturing also provide conditions for customized drug delivery platforms. Besides this, a complex spatial structure constructed based on 3D printing technology is also conducive to cell proliferation and differentiation, providing a new carrier for tissue engineering and repair. Biomedical applications based on 3D printing technology promote the development of precision medicine and personalized medicine and provide a new direction for further research and application of 3D printing technology.

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3D printed scaffolds of alginate/polyvinylalcohol with silk fibroin based on mimicked extracellular matrix for bone tissue engineering in maxillofacial surgery

Cited by 26 publications

References 36 publications

Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

Maillard Reaction Crosslinked Alginate-Albumin Scaffolds for Enhanced Fenofibrate Delivery to the Retina: A Promising Strategy to Treat RPE-Related Dysfunction

Recent advances in 3D printing hydrogel for topical drug delivery

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