3D-printed miniaturized fluidic tools in chemistry and biology

Dixit, Chandra Kumar; Kadimisetty, Karteek; Rusling, James F.

doi:10.1016/j.trac.2018.06.013

Cited by 63 publications

(42 citation statements)

References 202 publications

(237 reference statements)

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“…[1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology. [1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology.…”

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confidence: 99%

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Lin

Song

et al. 2020

Adv Materials Technologies

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and fine chemical industries. [1][2][3][4][5][6] As a core element of microfluidic technology, high-performance fabrication of hollow microchannels with freeform geometries is crucial for further developing innovative microfluidic technology. In particular, extension of the microfluidic networks from widely used 2D to 3D configurations has now been considered as a promising scheme to enhance the performance of manipulation of fluids such as high-efficiency mixing, separation, and detection. [7][8][9][10][11] Fused silica is one of the widely used substrates for the microfluidic technology in laboratory research and industrial applications due to its high melting point, high chemical stability, low thermal expansion coefficient, wide transmission spectral range, and good biocompatibility. However, fabrication of freeform 3D hollow microchannels in fused silica is still difficult for current 2D fabrication techniques in terms of complex and tedious fabrication procedures, additional costs for aligning, stacking, and bonding steps. [12][13][14] Currently, one of the most representative 3D microfabrication techniques of fused silica is ultrashort pulse laser microfabrication. [15][16][17][18][19][20] A suspended hollow microchannel structure with a 3D controllable configuration can be fabricated in a way of either laser-assisted selective wet etching [21][22][23] or liquid-assisted laser ablation. [24][25][26] In addition, suspended hollow structures with 3D shapes and a high precision in fused silica can be fabricated by combining room-temperature casting and sacrificial template replication. [27] Meanwhile, 3D printing of glass materials emerging in recent years brings some new opportunities for scalable fabrication of freeform glass structures by either additive manufacturing strategies [28][29][30][31][32][33] or laser subtractive processing methods. [34][35][36] However, controllable formation of freeform hollow microchannel with arbitrary length encapsulated in 3D printed glass structures has not yet been demonstrated, which is highly desirable for high-infidelity manufacturing of artificial organs, on-chip construction of biomimetic microenvironments, [37][38][39][40][41] as well as enrichment of the functions of continuous-flow microreactors (e.g., seamless integration of customized functional module for temperature control and on-line spectrometer monitoring). [42,43] Especially, simultaneous fabrication of 3D embedded hollow microchannels with high aspect ratios and centimeter-scale glass objects with external arbitrary shapes on/in a single substrate still Large-scale microfluidic microsystems with complex 3D configurations are highly in demand by both fundamental research and industrial application, holding the potentials for fostering a wide range of innovative applications such as organ-on-a-chip as well as continuous-flow manufacturing. However, freeform fabrication of such systems remains challenging for current fabrication techniques in terms of fabrication resolution, flexibility, and achievable foo...

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confidence: 99%

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Lin

Song

et al. 2020

Adv Materials Technologies

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“…This is most probably due to the intrinsic nature of the used polymeric matrix, which does not properly melt, but softens and degrades very quickly. On the other hand, PDMS-like polymers are often successfully 3D-printed by making changes in the traditional FDM experimental setup, for example, by switching the basic filament-dispensing system of an FDM machine with a syringe and needle, allowing them to avoid modifications in the stage, software, or the printing unit [ 27 ]. Hinton et al [ 28 ] used a hydrophilic support bath via freeform reversible embedding to extrude PDMS within the hydrophilic Carbopol gel that is later cured by heating in two rounds, managing to create perfusable manifolds using this technique.…”

Section: Resultsmentioning

confidence: 99%

A Feasibility Study of Processing Polydimethylsiloxane–Sodium Carboxymethylcellulose Composites by a Low-Cost Fused Deposition Modeling 3D Printer

et al. 2018

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Additive manufacturing (AM) techniques allow the construction of complex physical models reproducing the content of a specific CAD file, and, among them, Fused Deposition Molding (FDM) stands out for its many advantages. The aim of the present work is to perform a feasibility study of 3D printing of a model of human heart to be used to simulate surgical operations or for training through a two-step method based on extrusion and FDM processes. To this purpose, typical extrusion instrumentation and a simple and low-cost FDM printer are employed, in combination with a thermoplastic polydimethylsiloxane (PDMS), chosen for its transparency, flexibility, and high resistance to multiple agents and aging. To improve its tactile properties and mimic the slimy effect of living organs, sodium carboxymethylcellulose (Na–CMC) fibrils are added to it. The starting materials, the neat PDMS filament and the composite one, are deeply characterized in terms of structural, thermal, and rheological properties in order to fix the most suitable extrusion and FDM parameters. The composite filaments show larger diameter and roughness, which cause undesirable effects during 3D printing, such as episodic nozzle obstruction, and exhibit a faster degradation, making the FDM step difficult. Nevertheless, the major issues are related to the low crystallinity degree of the employed polymer. The feasibility study carried out leads to the printing of composite layers, even though far from the desired final target. Possible solutions to print the fully characterized Na–CMC/PDMS composite are addressed in the conclusion of this work.

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“…The objects are prone to develop structural defects and reduced mechanical strength; the mechanical performance often reveals anisotropic effects. The printing process is protracted if the Z axis resolution is high (for lower layer thickness) [ 1 , 30 , 31 , 35 , 41 ].…”

Section: 3d Printing Processmentioning

confidence: 99%

3D Printing in Heterogeneous Catalysis—The State of the Art

Богдан

Michorczyk

2020

Materials

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This paper describes the process of additive manufacturing and a selection of three-dimensional (3D) printing methods which have applications in chemical synthesis, specifically for the production of monolithic catalysts. A review was conducted on reference literature for 3D printing applications in the field of catalysis. It was proven that 3D printing is a promising production method for catalysts.

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3D-printed miniaturized fluidic tools in chemistry and biology

Cited by 63 publications

References 202 publications

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

Freeform Microfluidic Networks Encapsulated in Laser‐Printed 3D Macroscale Glass Objects

A Feasibility Study of Processing Polydimethylsiloxane–Sodium Carboxymethylcellulose Composites by a Low-Cost Fused Deposition Modeling 3D Printer

3D Printing in Heterogeneous Catalysis—The State of the Art

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