3D printed microfluidic devices for integrated solid-phase extraction and microchip electrophoresis of preterm birth biomarkers

Esene, Joule E.; Burningham, Addalyn J.; Tahir, Anum; Nordin, Gregory P.; Woolley, Adam T.

doi:10.1016/j.aca.2024.342338

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…Table summarizes recent contributions related to green sample preparation methods for bioanalysis. ,,− As it can be seen, there is not a clear preference for the use of liquid-based or solid-based extractions. A clear trend cannot be observed in the materials/solvents selected, with both commercial and lab-made alternatives being used.…”

Section: Green Sample Preparation Applied To Environmental and Biolog...mentioning

confidence: 99%

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Martínez-Pérez-Cejuela,

Gionfriddo

2024

Anal. Chem.

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Section: Green Sample Preparation Applied To Environmental and Biolog...mentioning

confidence: 99%

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Martínez-Pérez-Cejuela,

Gionfriddo

2024

Anal. Chem.

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“…LFIAs, founded on an affinity-capture-migration technology, occasionally yield falsenegative or false-positive misdiagnoses, yet they continue to be used as a screening tool [100][101][102][103]. Conversely, immunoaffinity capillary electrophoresis (IACE), based on the principle of an affinity-capture-separation or a two-dimensional technology, is a popular test due to its ability to confirm results [70,[103][104][105][106][107][108]. Even if there are doubts about the biomarker(s) separated by capillary electrophoresis (CE) (electropherogram), the CE outlet terminal can be coupled to a mass spectrometer that also validates findings.…”

Section: Potential Use Of Point-of-care Platforms For the Screening O...mentioning

confidence: 99%

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Guzman,

Guzman

2024

IJTM

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Many ailments can be diagnosed while they are asymptomatic, meaning that the patient has no signs or symptoms of a progressing disease. If caught in their initial stage of formation, these disorders can be effectively treated, leading to successful outcomes; curative therapies can halt illnesses from advancing, thus improving the quality of life and long-term survival of the patient. Still, cutting-edge upgrades in precision technologies are necessary for early, reliable, affordable, and rapid disease detection, but also vital for the well-being of people and the future of global public health. The emerging role and utility of non-invasive and repeatable diagnostic test approaches for the detection of health conditions have been exemplified by liquid biopsies based on genomic biomarkers. As such, biological fluids permit any measurable molecular indicator or signature (e.g., proteins) to provide valuable information on an individual’s wellness and/or disease. Among the bodily secretions used for non-invasive diagnostics is sputum, a complex viscous gel-like biopolymeric network that has gained growing recognition as a rich source of biomarkers of airway infections and pulmonary diseases, and serves as a determinant to reveal other illnesses. As per the World Health Organization, the burden of respiratory conditions is exacerbated by factors ranging from considerable subjection to air pollution and occupational contaminants to tobacco smoking and second-hand smoke, in addition to poor socio-economic status. Due to the likely increase in these determinants, respiratory tract ailments are on the rise, affecting the health of many individuals, in addition to putting stress on healthcare facilities and services worldwide. The aim of this study was to perform a narrative review of sputum constituents with an emphasis on proteins and glycoproteins assessed as possible biomarkers of lung and other organ diseases. A search was conducted using mucus, sputum proteomics, sputum biomarkers, and point-of-care testing as keywords employing Google, PubMed (MEDLINE), and Web of Science, selecting the most referenced and related papers of the last decade. We, therefore, highlight the need to use expectorated or induced sputum specimens as a routine sample source for testing valuable protein biomarkers to diagnose these chronic disorders, predict inflammation and disease progression, as well as monitor the effectiveness of treatments. Further, we discuss the urgent need for fast and reliable point-of-care methods to detect and quantify crucial protein biomarkers in sputum specimens, and the limitations faced when dealing with their complex matrices.

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A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications

Duarte,

Figueredo,

Chagas

et al. 2024

Analytica Chimica Acta

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3D printed microfluidic devices for integrated solid-phase extraction and microchip electrophoresis of preterm birth biomarkers

Cited by 3 publications

References 50 publications

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications

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