A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications

Duarte, Lucas C.; Figueredo, Federico; Chagas, Cyro L.S.; Cortón, Eduardo; Coltro, Wendell K.T.

doi:10.1016/j.aca.2024.342429

Cited by 4 publications

(2 citation statements)

References 120 publications

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“…Microfluidic systems with sensing, braking, controlling, and other functions have been quickly developed recently. Microelectrodes, in particular, are crucial components of microfluidic systems.…”

Section: Introductionmentioning

confidence: 99%

EBiIn-Cu-GaIn Composite Electrodes inside Microfluidic Chips

Zhang,

Li,

Sun

et al. 2024

ACS Appl. Electron. Mater.

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Fusible metal electrodes are one of the hot research topics today and have been more widely used in the field of microfluidics. Although many microfabrication-based techniques have been widely applied to various microstructures, current research is still unable to satisfy the use of electrodes in some extreme environments, such as the warning of electrodes in the case of thermal runaway (high temperature and high mechanical stress) in electric vehicles. In order to make the electrodes more adaptable to various environments, we have developed a method to fabricate EBiIn-Cu-GaIn composite electrodes within a single-layer microfluidic channel using a galvanic replacement reaction. The composite electrodes, which combine the advantages of miniaturization, flexibility, good mechanical properties, and high-temperature resistance, can withstand bending at 90°, stretching at 230%, and pressure at 2.7 MPa. The composite electrode was also used to fabricate a miniature heater with a heating temperature of up to 278 °C.

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Section: Introductionmentioning

confidence: 99%

EBiIn-Cu-GaIn Composite Electrodes inside Microfluidic Chips

Zhang,

Li,

Sun

et al. 2024

ACS Appl. Electron. Mater.

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“…3D printing represents an emerging technology in several fields, including engineering, medicine, and chemistry. The manufacturing of miniaturized devices is becoming increasingly popular among users pursuing the homemade fabrication of reproducible and low-cost microdevices in a single step [ 1 ]. It is important to highlight that the miniaturization of devices also leads to a reduction in the amount of printing materials used and the generation of waste [ 2 ].…”

mentioning

confidence: 99%

3D-Printed Microdevices: From Design to Applications

Kalinke,

Muñoz

2024

Micromachines

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Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA

Rodríguez,

Báez-Suárez,

Muñoz-Camargo

et al. 2024

Micromachines

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Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broader application. This study introduces a novel microfluidic device that leverages the passive Zweifach–Fung principle to overcome these financial barriers. Through Lagrangian computational simulations, we optimized an eleven-channel Zweifach–Fung configuration that achieved a perfect 100% recall rate for particles following a specified normal distribution. Experimental evaluations determined 2 mL/h as the optimal total flow rate (TFR), under which the device showcased exceptional performance enhancements in precision and recall for micrometer-sized particles, achieving an overall accuracy of 94% ± 3%. Fabricated using a cost-effective, non-cleanroom method, this approach represents a significant shift from conventional practices, dramatically reducing production costs while maintaining high operational efficacy. The cost of each chip is less than USD 0.90 cents and the manufacturing process takes only 15 min. The development of this device not only makes microfluidic technology more accessible but also sets a new standard for future advancements in the field.

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A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications

Cited by 4 publications

References 120 publications

EBiIn-Cu-GaIn Composite Electrodes inside Microfluidic Chips

EBiIn-Cu-GaIn Composite Electrodes inside Microfluidic Chips

3D-Printed Microdevices: From Design to Applications

Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA

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