3D-printed magnetic Fe<sub>3</sub>O<sub>4</sub>/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

Zhang, Jianhua; Zhao, Shichang; Zhu, Menglin; Zhu, Yufang; Zhang, Yadong; Liu, Zhongtang; Zhang, Changqing

doi:10.1039/c4tb01063a

Cited by 262 publications

(190 citation statements)

References 62 publications

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“…Mechanical strength of ceramic scaffolds in bone tissue engineering also plays crucial roles [48,49]. As shown in Figure 4, the mechanical strengths of β-Ca 2 SiO 4 scaffolds were remarkably enhanced by sintering temperature ( p < 0.05) and an average compressive strength of 5.2 MPa actually was measured on the β-Ca 2 SiO 4 scaffolds sintered at 1200 °C with a porosity of 78.3 ± 0.7%.…”

Section: Discussionmentioning

confidence: 99%

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Liu

et al. 2018

Science and Technology of Advanced Materials

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Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca2SiO4 scaffolds have been successfully fabricated from preceramic resin loaded with CaCO3 active filler by 3D printing. The fabricated β-Ca2SiO4 scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca2SiO4 scaffolds derived from preceramic resin and CaCO3 active fillers would be promising candidates for bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Liu

et al. 2018

Science and Technology of Advanced Materials

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“…34 Fused deposition modelling (FDM) based printing methods, in which a material in molten form is extruded layer by layer on the printing bed, has also been applied for scaffold fabrication. 3D printed polymeric scaffolds consisting of HA, 45 bioactive glass, magnetic particles incorporated into mesoporous bioactive glass materials, 12 TCP, 46 and zirconium oxide, 47 have all been manufactured using FDM printing. The composite scaffolds produced present a number of promising platforms for bone regeneration, with enhanced properties reported, including superior bioactivity, osteogenic ability, and mineralization of human bone marrow-derived mesenchymal stem cells.…”

Section: D Printable Composite Materials For Biomedical Applicationsmentioning

confidence: 99%

“…7 Running parallel to these technological developments, there has also been rapidly growing interest in the preblending of materials and/or the inclusion of 'fillers' into printable resins, which deliver distinct physicochemical properties into the resultant materials, thus producing 3D printed composites which exhibit unique characteristics and capabilities. [8][9][10][11][12][13][14][15] Indeed, in the area of composite design and production, 3D printing represents a technology with immense potential, again providing low cost, simple and rapid prototyping advantages over traditional methods for fabrication of composite materials and objects. rication methods, applications, advantages and limitations.…”

Section: Introductionmentioning

confidence: 99%

Recent developments in 3D printable composite materials

2016

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3D printing technology is now frequently employed in many areas of research and development. However, a relatively narrow range of 3D printable materials with a limited spectrum of physico-chemical properties still restricts the true potential of this potentially disruptive technology. There is rapidly increasing interest in the improvement and diversification of properties of generic printing materials via the introduction of fillers with unique properties, and/or by blending materials exhibiting different properties to generate high performance composites. 3D printed composites have already been utilised in a wide range of applications, including biomedical, mechanical, electrical, thermal and optically enhanced products. The increasing popularity of 3D printed composites can be attributed to the ability to fabricate complex geometries, low cost production, and other advantages associated with rapid prototyping. This review covers all the recent reports in which the properties of generic 3D printable materials have been modified either by adding nanoparticles, fibers, other polymers, or by a chemical reaction for fabrication of composites with enhanced biometerial, mechanical, electrical, thermal, optical and other properties.

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“…Magnetic particles integrated into the composition of scaffolds are also currently being studied as a means to generate localized hyperthermia [55]. This is achieved by exposure to alternating magnetic fields which cause oscillation of the particle's magnetic moment and consequently result in heat release.…”

Section: Stimuli-triggered Drug Deliverymentioning

confidence: 99%

Bone Tissue Engineering Drug Delivery

Costa

2015

Curr Mol Bio Rep

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Tissue engineering shows the potential to address the growing demand for bone tissue substitutes resulting from trauma, disease, and ageing. The utilization of drugs in combination with tissue engineering strategies has resulted in a new generation of osteoinductive scaffolds which are able to improve the speed and quality of new bone formation. This review briefly describes some of the most recent and innovative advances resulting from the combination of drug delivery methodologies with tissue engineering strategies directed at the regeneration of bone tissue. It describes some of the most commonly utilized drugs as well as some of the strategies most commonly employed to accurately direct the delivery of drugs to specific sites and cells. This review also describes several strategies which enable controlled drug release in response to specific stimuli which can be provided by the surrounding environment or medically induced.

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3D-printed magnetic Fe₃O₄/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

Abstract: The 3D-printed Fe3O4/MBG/PCL scaffolds with potential multifunctionality would be promising for use in the treatment and regeneration of large bone defects after tumor resection.

Cited by 262 publications

References 62 publications

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Recent developments in 3D printable composite materials

Bone Tissue Engineering Drug Delivery

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3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

Abstract: The 3D-printed Fe3O4/MBG/PCL scaffolds with potential multifunctionality would be promising for use in the treatment and regeneration of large bone defects after tumor resection.

Cited by 262 publications

References 62 publications

3D printed porous β-Ca2SiO4scaffolds derived from preceramic resin and their physicochemical and biological properties

3D printed porous β-Ca2SiO4scaffolds derived from preceramic resin and their physicochemical and biological properties

Recent developments in 3D printable composite materials

Bone Tissue Engineering Drug Delivery

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Product

Resources

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3D-printed magnetic Fe₃O₄/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties