3D printed hydrogel/PCL core/shell fiber scaffolds with NIR-triggered drug release for cancer therapy and wound healing

Liu, Chunyang; Wang, Zhiyong; Wei, Xu; Chen, Birui; Luo, Yongxiang

doi:10.1016/j.actbio.2021.07.011

Cited by 79 publications

(46 citation statements)

References 48 publications

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“…Alginate-gelatin PDA PCL coating helps the core gel to retain the drugs. [ 106] PNIPam and cellulose nanocrystals Fe 3 O 4 NPs CNCs improve the mechanical properties of PNIPam hydrogel.…”

Section: Combination Therapymentioning

confidence: 94%

Hydrogel Combined with Phototherapy in Wound Healing

Chen

Ying

et al. 2022

Adv Healthcare Materials

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Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.

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“…Alginate-gelatin PDA PCL coating helps the core gel to retain the drugs. [ 106] PNIPam and cellulose nanocrystals Fe 3 O 4 NPs CNCs improve the mechanical properties of PNIPam hydrogel.…”

Section: Combination Therapymentioning

confidence: 94%

Hydrogel Combined with Phototherapy in Wound Healing

Chen

Ying

et al. 2022

Adv Healthcare Materials

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“…Hydrogel fibers can be further functionalized by surface modifications to endow them with special functions. For example, Liu et al (2021) used 3D printing technology to prepare core-shell hydrogel/Polycaprolactone fibers and grafted a layer of dopamine on the outermost layer to endow it with the ability of NIR-triggered drug release.…”

Section: Structure Of Hydrogels For Wound Healingmentioning

confidence: 99%

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

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“…Next, Phospholipase A2 hydrolyzes the liposomal lecithin, thereby destroying the liposomes and releasing curcumin to kill bacteria in infected wounds. Liu et al [ 173 ] reported a near-infrared (NIR) laser triggered on-demand drug release for wound healing and cancer therapy. Briefly, a homogeneous layer of polycaprolactone was coated on a 3D printed alginate-gelatin hydrogel scaffolds aiming to reduce the free diffusion of drugs from the core gels.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%