3D-printed “fistula stent” designed for management of enterocutaneous fistula: An advanced strategy

Huang, Jinjian; Ren, Jianan; Wang, Gefei; Li, Zongan; Wu, Xiuwen; Ren, Huajian; Liu, Song

doi:10.3748/wjg.v23.i41.7489

Cited by 40 publications

(43 citation statements)

References 10 publications

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“…The first limitation is that the PORO-LAY scaffolds are made from a proprietary blend of polyurethane and polyvinyl alcohol. While polyvinyl alcohol is well known to be food safe and nontoxic [ 51 ], compatibility and use of 3D printed polyurethane scaffolds is only beginning to gain attention [ 52 , 53 , 54 ]. Polyurethanes have long been used in biomedical tubing, catheters, and for some time, in breast and skin medical applications.…”

Section: Discussionmentioning

confidence: 99%

Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer

et al. 2018

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The spine is the most common site of bone metastasis, often originating from prostate, lung, and breast cancers. High systemic doses of chemotherapeutics such as doxorubicin (DOX), cisplatin, or paclitaxel often have severe side effects. Surgical removal of spine metastases also leaves large defects which cannot spontaneously heal and require bone grafting. To circumvent these issues, we designed an approach for local chemotherapeutic delivery within 3D-printed scaffolds which could also potentially serve as a bone substitute. Direct treatment of prostate cancer cell line LAPC4 and patient derived spine metastases cells with 0.01 µM DOX significantly reduced metabolic activity, proliferation, migration, and spheroid growth. We then assessed uptake and release of DOX in a series of porous 3D-printed scaffolds on LAPC4 cells as well as patient-derived spine metastases cells. Over seven days, 60–75% of DOX loaded onto scaffolds could be released, which significantly reduced metabolic activity and proliferation of both LAPC4 and patient derived cells, while unloaded scaffolds had no effect. Porous 3D-printed scaffolds may provide a novel and inexpensive approach to locally deliver chemotherapeutics in a patient-specific manner at tumor resection sites. With a composite design to enhance strength and promote sustained drug release, the scaffolds could reduce systemic negative effects, enhance bone repair, and improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer

et al. 2018

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“…Concerning the potentials of intestinal organoids in gut repair, preparations of organoid‐laden scaffolds that accord with intestinal tract anatomy are of great basic and clinical importance. To realize this purpose, development of printable and organoid‐compatible hydrogels is promising because they can be used to produce personalized scaffolds by 3D‐printing technology (Huang et al, ; Madden et al, ; Xu, Ren, Huang, Li, & Ren, ). Moreover, compared with chemical fluorescent compounds, fusion of fluorescent protein genes using CRISPR‐Cas9 causes the least influence to intestinal organoids.…”

Section: Future Directionsmentioning

confidence: 99%

Biomaterials and biosensors in intestinal organoid culture, a progress review

Huang

Jiang

Ren

et al. 2020

J Biomedical Materials Res

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As an emerging technology, intestinal organoids are promising new tools for basic and translational research in gastroenterology. Currently, culture of intestinal organoids relies mostly on a type of tumor-derived scaffolds, namely Matrigel, which may pose tumorigenic risks to organoid implantation. Apart from the traditional detection methods, such as tissue slicing and fluorescence staining, the monitoring of intestinal organoids requires real-time biosensors that can adapt to their threedimensional dynamic growth patterns. In this review, we summarized the recent advances in developing definite hydrogel scaffolds for intestinal organoid culture and identified key parameters for scaffold design. In addition, classified by different substrate compositions like pH, electrolytes, and functional proteins, we concluded the existing live-imaging biosensors and elucidated their underlying mechanisms. We hope this review enhances the understanding of intestinal organoid culture and provides more practical approaches to investigate them. K E Y W O R D Sbiosensor, intestinal stem cell, organoid, regenerative medicine, scaffold design

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“…have 3D printed a fistula stent using an FDM printer that uses a pharmaceutical grade thermoplastic polyurethane (TPU) filament. These researchers have also provided clinical results 17 . Although their work shows the successful usage of a 3D-printed patient-specific stent, we must emphasize that such practices are very rare and that no long-term follow-up study has been conducted.…”

Section: Introductionmentioning

confidence: 99%

Shape transformable bifurcated stents

Kim

Lee

2018

Sci Rep

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Non-invasive delivery of artificial implants, stents or devices in patients is vital for rapid and successful recovery. Unfortunately, because the delivery passage is often narrower than the size of the delivered object, a compromise between the shape that is effective at the targeted location and a thin form that allows smooth unobstructed travel to the destination is needed. We address this problem through two key technologies: 3D printing and shape memory polymers (SMPs). 3D printing can produce patient-customizable objects, and SMPs can change their initially formed shape to the final desired shape through external stimulation. Using these two technologies, we examine the design and fabrication of bifurcated stents. This study presents a mock-up where blood vessels are fabricated using moulded silicon, which supports the effectiveness of the proposed method. The experimental results reveal that a bifurcated stent with a kirigami structure can smoothly travel inside a vessel without being obstructed by branched parts. We believe that this work can improve the success rate of stent insertion operations in medicine.

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3D-printed “fistula stent” designed for management of enterocutaneous fistula: An advanced strategy

Cited by 40 publications

References 10 publications

Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer

Nanoporous 3D-Printed Scaffolds for Local Doxorubicin Delivery in Bone Metastases Secondary to Prostate Cancer

Biomaterials and biosensors in intestinal organoid culture, a progress review

Shape transformable bifurcated stents

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