3D printed chitosan/polycaprolactone scaffold for lung tissue engineering: hope to be useful for COVID-19 studies

Rezaei, Farnoush Sadat; Khorshidian, Ayeh; Beram, Farzaneh Mahmoudi; Derakhshani, Atefeh; Esmaeili, Javad; Barati, Aboulfazl

doi:10.1039/d1ra03410c

Cited by 36 publications

(20 citation statements)

References 61 publications

(71 reference statements)

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“…Infecting the scaffol Other 3D printed devices to help reduce lung complications due to SARS-CoV-2 include 3D bioprinted scaffolds for lung tissue. A study from Rezaei et al use 3D bioprinted chitosan/polycaprolactone (CS/PCL) scaffolds to study how COVID-19 infects the lungs by engineering new lung tissue which can be used to test drugs and vaccines to combat the virus [51]. Unlike 2D cell cultures, the 3D bioprinted CS/PCL scaffolds inherit enough porosity to simulate a lung structure effectively allowing for fluids and oxygen to penetrate the scaffold for cell attachment, growth, and proliferation [51].…”

Section: D Printing For Lung Surgerymentioning

confidence: 99%

“…A study from Rezaei et al use 3D bioprinted chitosan/polycaprolactone (CS/PCL) scaffolds to study how COVID-19 infects the lungs by engineering new lung tissue which can be used to test drugs and vaccines to combat the virus [51]. Unlike 2D cell cultures, the 3D bioprinted CS/PCL scaffolds inherit enough porosity to simulate a lung structure effectively allowing for fluids and oxygen to penetrate the scaffold for cell attachment, growth, and proliferation [51]. Infecting the scaffold with COVID-19 to test drugs and vaccines can lead to accurate results for studying pneumonia, ARDS and sepsis, and provide information on how to treat these diseases in the future [51].…”

Section: D Printing For Lung Surgerymentioning

confidence: 99%

“…Unlike 2D cell cultures, the 3D bioprinted CS/PCL scaffolds inherit enough porosity to simulate a lung structure effectively allowing for fluids and oxygen to penetrate the scaffold for cell attachment, growth, and proliferation [51]. Infecting the scaffold with COVID-19 to test drugs and vaccines can lead to accurate results for studying pneumonia, ARDS and sepsis, and provide information on how to treat these diseases in the future [51]. With limited donor lung availability, graft rejections and post-operation problems, successful lung transplantation is a modern issue [52].…”

Section: D Printing For Lung Surgerymentioning

confidence: 99%

“…With limited donor lung availability, graft rejections and post-operation problems, successful lung transplantation is a modern issue [52]. Further, 3D bioprinting is an option to develop fully functioning engineered lung tissue that can be used to treat lung complications caused by COVID-19 [51]. Human lung tissues can be developed using biological or synthetically developed scaffolds, or with decellularized scaffolds from an animal or human donor, and incorporating various cell types native to lung tissues [53].…”

Section: D Printing For Lung Surgerymentioning

confidence: 99%

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3D Printing for Medical Applications: Current State of the Art and Perspectives during the COVID-19 Crisis

et al. 2021

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The coronavirus SARS-CoV-2 pandemic has affected over one hundred million people worldwide and has resulted in over two million deaths. In addition to the toll that coronavirus takes on the health of humans infected with the virus and the potential long term effects of infection, the repercussions of the pandemic on the economy as well as on the healthcare system have been enormous. The global supply of equipment necessary for dealing with the pandemic experienced extreme stress as healthcare systems around the world attempted to acquire personal protective equipment for their workers and medical devices for treating COVID-19. This review describes how 3D printing is currently being used in life saving surgeries such as heart and lung surgery and how 3D printing can address some of the worldwide shortage of personal protective equipment, by examining recent trends of the use of 3D printing and how these technologies can be applied during and after the pandemic. We review the use of 3D printed models for treating the long term effects of COVID-19. We then focus on methods for generating face shields and different types of respirators. We conclude with areas for future investigation and application of 3D printing technology.

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Section: D Printing For Lung Surgerymentioning

confidence: 99%

Section: D Printing For Lung Surgerymentioning

confidence: 99%

Section: D Printing For Lung Surgerymentioning

confidence: 99%

Section: D Printing For Lung Surgerymentioning

confidence: 99%

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3D Printing for Medical Applications: Current State of the Art and Perspectives during the COVID-19 Crisis

et al. 2021

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“…The catheter-injectable gelatin-alginate hydrogel expands the scope of tissue engineering and less invasive surgery. It is a low-cost, easy-to-use alternative to the many lung tissue engineering scaffolds now available [103].…”

Section: Regeneration Of Lung Tissue Using Biopolymeric Scaffoldsmentioning

confidence: 99%

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

et al. 2021

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The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored.

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Bioplastic From Renewable Biomass

Singh

Rachna

et al. 2022

Handbook of Bioplastics and Biocomposites Engineering Applications

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3D printed chitosan/polycaprolactone scaffold for lung tissue engineering: hope to be useful for COVID-19 studies

Abstract: The aim of this study was to provide a biologically and mechanically suitable 3D printed scaffold using chitosan/polycaprolactone bioink for lung tissue engineering.

Cited by 36 publications

References 61 publications

3D Printing for Medical Applications: Current State of the Art and Perspectives during the COVID-19 Crisis

3D Printing for Medical Applications: Current State of the Art and Perspectives during the COVID-19 Crisis

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

Bioplastic From Renewable Biomass

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