3D printed bioresorbable nitric oxide-releasing vascular stents

Oliveira, Matheus F. de; Silva, Laura C. E. da; Oliveira, Marcelo Ganzarolli de

doi:10.1016/j.bprint.2021.e00137

Cited by 15 publications

(13 citation statements)

References 47 publications

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“…Notably, our one-step method for the fabrication of devicedrug combination products is inherently different from previous work on 3D printing of drug-free polymer devices followed by coating of a NO donor layer 39 or solvent-assisted impregnation of the NO donor. 40,41 To the best of our knowledge, this is the first report that a NO-releasing device is directly 3D-printed.…”

Section: T H Imentioning

confidence: 93%

“…Therefore, our 3D printing method based on the moisture curing silicone without using any heat or light is highly suited for printing of inks containing S -nitrosothiols. Notably, our one-step method for the fabrication of device-drug combination products is inherently different from previous work on 3D printing of drug-free polymer devices followed by coating of a NO donor layer or solvent-assisted impregnation of the NO donor. , To the best of our knowledge, this is the first report that a NO-releasing device is directly 3D-printed.…”

Section: Introductionmentioning

confidence: 93%

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3D Printing of Antibacterial Polymer Devices Based on Nitric Oxide Release from Embedded S-Nitrosothiol Crystals

Yang

Ehrhardt

et al. 2021

ACS Appl. Bio Mater.

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Controlled release of drugs from medical implants is an effective approach to reducing foreign body reactions and infections. We report here on a one-step 3D printing strategy to create drug-eluting polymer devices with a drug-loaded bulk and a drug-free coating. The spontaneously formed drug-free coating dramatically reduces the surface roughness of the implantable devices and serves as a protective layer to suppress the burst release of drugs. A high viscosity liquid silicone that can be extruded based on its shear-thinning property and quickly vulcanize upon exposure to ambient moisture is used as the ink for 3D printing. S-Nitrosothiol type nitric oxide (NO) donors in their crystalline forms are selected as model drugs because of the potent antimicrobial, antithrombotic, and anti-inflammatory properties of NO. Direct ink writing of the homogenized polymer-drug mixtures generates rough and ill-defined device surfaces because of the exposed S-nitrosothiol microparticles. When a low-viscosity silicone (polydimethylsiloxane) is added into the ink, this silicone diffuses outward upon deposition to form a drug-free outermost layer without compromising the integrity of the printed structures. S-Nitrosoglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP) embedded in the printed silicone matrix releases NO under physiological conditions from days to about one month. The microsized drug crystals are well-preserved in the ink preparation and printing processes, which is one reason for the sustained NO release. Biofilm and cytotoxicity experiments confirmed the antibacterial property and safety of the printed NO-releasing devices. This additive manufacturing platform does not require dissolution of drugs and involves no thermal or UV processes and, therefore, offers unique opportunities to produce drug-eluting silicone devices in a customized manner.

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Section: T H Imentioning

confidence: 93%

Section: Introductionmentioning

confidence: 93%

3D Printing of Antibacterial Polymer Devices Based on Nitric Oxide Release from Embedded S-Nitrosothiol Crystals

Yang

Ehrhardt

et al. 2021

ACS Appl. Bio Mater.

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“…Copolyester Synthesis: The random copolymer, methacrylated poly(dodecanediol citrate-co-dodecanediol mercaptosuccinate) (mP(DCco-DM)), was synthesized in a one-pot, two-step process. [37] The first step was the poly(dodecanediol citrate-co-dodecanediol mercaptosuccinate) (P(DC-co-DM)) backbone synthesis via the in bulk co-condensation of citric acid (C), mercaptosuccinic acid (M), and 1,12-dodecanediol. This reaction was performed under magnetic stirring at 140 °C for 30 min using the molar ratios described in Table S1, Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…Following this line, we have recently reported the incorporation of the NO donor S‐nitroso‐N‐acetylpenicilamine in 3D printed mPDC stents via absorption from ethanolic solution. [ 37 ] This approach has expanded the use of the S‐nitrosothiols (RSNO) as a platform for NO delivery [ 38 ] to the 3D printing of NO‐releasing biomaterials. [ 39 ] In the present work, we have taken a step forward to obtain a bioresorbable and elastomeric NO‐releasing polyester for the 3D printing of BVS, which have RSNO groups chemically bonded to the polymer backbone.…”

Section: Introductionmentioning

confidence: 99%

Photocurable Nitric Oxide‐Releasing Copolyester for the 3D Printing of Bioresorbable Vascular Stents

Oliveira

Silva

Catori

et al. 2022

Macromolecular Bioscience

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The design of bioresorbable vascular stents (BVS) capable of releasing nitric oxide (NO) at the implant site may enable BVS to mimic the antiplatelet, antiproliferative, and pro‐endothelial actions of NO, overcoming complications of BVS such as late thrombosis and restenosis. In this study, the fabrication of BVS composed of methacrylated poly(dodecanediol citrate‐co‐dodecanediol S‐nitroso‐mercaptosuccinate) (mP(DC‐co‐DMSNO)), a novel elastomeric, bioabsorbable, and photocurable copolyester, containing covalently bound S‐nitrosothiol groups in the carbon backbone of the polymer, is reported. The mP(DC‐co‐DMSNO) stents are manufactured via photoinduced 3D printing and allow deployment via a self‐expansion process from a balloon catheter. After deployment, hydration of the stents triggers the release of NO, which is maintained during the slow hydrolysis of the polymer. Real‐time NO release measurements show that by varying the copolyester composition and the strut geometry of the mP(DC‐co‐DMSNO) stents, it is possible to modulate their NO release rate in the range of 30–52 pmol min−1 cm−2. Preliminary biological assays in cell culture show that endothelial cells adhere to the surface of the stents and that NO release favors their endothelization. Thus, mP(DC‐co‐DMSNO) may emerge as a new platform for the fabrication of advanced BVS.

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“…[40] The type of drugs and drug efficacy have a great impact the effectiveness of suppressing the excessive hyperplasia of neointima. Some strategies showed promising via the local release of antioxidants [41] or endogenous molecules (e.g., prostacyclin [42] and nitric oxide [43] ) to either inhibit the oxidative stress or mimic the endothelium function after stent implantation. However, the real clinical breakthrough came with the use of the antiproliferative drugs, sirolimus and paclitaxel.…”

Section: Stent Design Of Desmentioning

confidence: 99%

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

Wang

Yang

et al. 2022

Advanced Materials

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Cardiovascular diseases have become the leading cause of death worldwide. The increasing burden of cardiovascular diseases has become a major public health problem and how to carry out efficient and reliable treatment of cardiovascular diseases has become an urgent global problem to be solved. Recently, implantable biomaterials and devices, especially minimally invasive interventional ones, such as vascular stents, artificial heart valves, bioprosthetic cardiac occluders, artificial graft cardiac patches, atrial shunts, and injectable hydrogels against heart failure, have become the most effective means in the treatment of cardiovascular diseases. Herein, an overview of the challenges and research frontier of innovative biomaterials and devices for the treatment of cardiovascular diseases is provided, and their future development directions are discussed.

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3D printed bioresorbable nitric oxide-releasing vascular stents

Cited by 15 publications

References 47 publications

3D Printing of Antibacterial Polymer Devices Based on Nitric Oxide Release from Embedded S-Nitrosothiol Crystals

3D Printing of Antibacterial Polymer Devices Based on Nitric Oxide Release from Embedded S-Nitrosothiol Crystals

Photocurable Nitric Oxide‐Releasing Copolyester for the 3D Printing of Bioresorbable Vascular Stents

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

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