3D-printed bioactive scaffolds for bone regeneration bearing carbon dots for bioimaging purposes

Saranti, A.; Tiron-Stathopoulos, Andreas; Papaioannou, Ligeri; Gioti, Christina; Ioannou, Andreas; Karakassides, Michael A.; Avgoustakis, Konstantinos; Koutselas, Ioannis; Dimos, Konstantinos

doi:10.1016/j.smaim.2021.11.002

Cited by 25 publications

(10 citation statements)

References 51 publications

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“…However, the Ca/P ratio of the ower-like objects was lower because the Ca 2+ ions in HA had exchanged with H + in the SBF solution, resulting in a decrease in Ca 2+ ions and increase in phosphorus ions in the HA. This agrees with the ndings of Saranti et al for PLA/HA composite lament in SBF [45].…”

Section: Simulated Body Fluid Evaluationsupporting

confidence: 93%

Fabrication and functionality of 3D-printed porous scaffolds composing natural derivatives of duck bones and fish shells and poly(ε-caprolactone)

Shih

Wang

et al. 2022

Preprint

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Recycled duck bones (DBs) and fish shells were processed into natural derivatives. Through innovative design, these natural derivatives were then combined with biopolymers to create a new type of ecofriendly filament suitable for three-dimensional (3D) printing of scaffolds for bone regeneration. The DBs and fish shells were thermally processed to produce DB-derived hydroxyapatite (HA) and fish shell-derived Ca(OH)2 (TAS), respectively. Poly(ε-caprolactone) (PCL), HA, and TAS were combined and fabricated into new composite filaments, which were then transformed into scaffolds using 3D printing technology. The structure and antibacterial behaviors of the obtained composite scaffolds were studied. Alone, PCL showed no bacterial inhibition. MHA (a mix of HA and TAS) was added to PCL to form a PCL/MHA composite material, which significantly improved the functional properties of PCL and enhanced cell attachment and proliferation. The Ca(OH)2 content of TAS was responsible for the antibacterial effect. The PCL/MHA composites were porous and displayed enhanced osteoblast proliferation in vitro. The osteoblast cell population do not affected when cultured on the PCL/HA and PCL/MHA series composites according to cell cycle distribution analysis. The surfaces of the various PCL/HA and PCL/MHA composites showed elevated levels of calcium and phosphorus compounds when exposed to simulated body fluids. Calcium and phosphate ions were rapidly deposited on PCL/HA and PCL/MHA composite scaffolds in osteoblasts according to the cell mineralization assay. Our findings suggest great potential of the PCL/HA and PCL/MHA composite scaffolds in bone tissue engineering applications.

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Section: Simulated Body Fluid Evaluationsupporting

confidence: 93%

Fabrication and functionality of 3D-printed porous scaffolds composing natural derivatives of duck bones and fish shells and poly(ε-caprolactone)

Shih

Wang

et al. 2022

Preprint

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“…CDs have shown great potential for tissue engineering and regenerative medicine [ 58 , 59 , 60 ]. For instance, chitosan–CD nanocomposites were constructed for enhancing wound healing [ 61 ].…”

Section: Waste To Wealth: Biowaste-derived Cds With Biomedical Potentialmentioning

confidence: 99%

Biowaste-Derived Carbon Dots: A Perspective on Biomedical Potentials

2022

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Today, sustainable and natural resources including biowastes have been considered attractive starting materials for the fabrication of biocompatible and biodegradable carbon dots (CDs) due to the benefits of availability, low cost, biorenewability, and environmentally benign attributes. These carbonaceous nanomaterials have been widely explored in the field of sensing/imaging, optoelectronics, photocatalysis, drug/gene delivery, tissue engineering, regenerative medicine, and cancer theranostics. Designing multifunctional biowaste-derived CDs with a high efficacy-to-toxicity ratio for sustained and targeted drug delivery, along with imaging potentials, opens a new window of opportunity toward theranostic applications. However, crucial challenges regarding the absorption/emission wavelength, up-conversion emission/multiphoton fluorescence mechanisms, and phosphorescence of these CDs still need to be addressed to attain the maximum functionality and efficacy. Future studies ought to focus on optimizing the synthesis techniques/conditions, evaluating the influence of nucleation/growth process on structures/properties, controlling their morphology/size, and finding the photoluminescence mechanisms. Reproducibility of synthesis techniques is another critically important factor that needs to be addressed in the future. Herein, the recent developments related to the biowaste-derived CDs with respect to their biomedical applications are deliberated, focusing on important challenges and future perspectives.

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“…Bone repair is a complex process involving complex linkages between osteoblasts, the ECM, and bone-inducing factors and is affected by bacterial toxin-based oxidative stress [81]. Natural-based hydrogels can mimic the ECM [214] by introducing bone-inducing materials to accelerate bone repair and angiogenesis [88,89,207,212,[215][216][217][218][219][220][221][222][223][224][225]. However, in some specific bone defect sites, the current natural hydrogels cannot meet the clinical requirements for fast bonding and high mechanical strength.…”

Section: Bone Tissue Repairmentioning

confidence: 99%

Natural polymer‐based adhesive hydrogel for biomedical applications

Long

Xie

2022

Biosurface and Biotribology

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Hydrogel is a polymer network system that can form a hydrophilic three‐dimensional network structure through different cross‐linking methods. In recent years, hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross‐linking mechanisms and functional components. Compared with synthetic hydrogels, natural polymer‐based hydrogels have low biotoxicity, high cell affinity, and great potential for biomedical fields; however, their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements. In recent years, many efforts have been made to solve these issues. In this review, the recent progress in the field of natural polymer‐based adhesive hydrogels is highlighted. The authors first introduce the general design principles for the natural polymer‐based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design. Next, their usages in biomedical applications are summarised, such as wound healing, haemostasis, nerve repair, bone tissue repair, cartilage tissue repair, electronic devices, and other tissue repairs. Finally, the potential challenges of natural polymer‐based adhesive hydrogels are presented.

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3D-printed bioactive scaffolds for bone regeneration bearing carbon dots for bioimaging purposes

Cited by 25 publications

References 51 publications

Fabrication and functionality of 3D-printed porous scaffolds composing natural derivatives of duck bones and fish shells and poly(ε-caprolactone)

Fabrication and functionality of 3D-printed porous scaffolds composing natural derivatives of duck bones and fish shells and poly(ε-caprolactone)

Biowaste-Derived Carbon Dots: A Perspective on Biomedical Potentials

Natural polymer‐based adhesive hydrogel for biomedical applications

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