3D Printed Antibiotic and Chemotherapeutic Eluting Catheters for Potential Use in Interventional Radiology

Abstract

The 3D printing manufacturing method to create instruments in percutaneous procedures is feasible. Further in vivo studies will substantiate these findings.

Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

“…Although coatings have been proven to prevent adherence of bacteria in most cases, coatings have some limitations. Currently depending on the type of coating, a concentration of 2% (w/w) is needed for an antimicrobial effect, whereas a study with 3D-printed catheter tips has shown antimicrobial properties present from as little as 1% (w/w) [30].…”

“…The use of additive manufacturing for catheter preparation has been barely described in the literature. There are two papers describing the use of this technology for catheter preparation [30,53]. These basic studies are proof of concept studies and accordingly contain many aspects that should be improved before this technology can be applied to patients.…”

“…This is confirmed at 20,000× magnification, which highlights the amorphous configuration of gentamicin (C, circles). Reproduced with permission from Weisman et al [30]. Copyright 2019 Elsevier.…”

“…PLA has also been proven for its uses within HME, with studies showing the manufacture of dexamethasone implants for the controlled release of immunosuppressive and anti-inflammatory drugs [71,72]. Moreover, PLA has been recently used to manufacture 3D-printed catheters containing a chemotherapeutic agent (methotrexate) or an antibiotic (gentamicin sulphate) to be used as a type of personalized medicine in interventional radiology [30].…”

Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation

“…The chosen demonstrator device differs in approach to other anti-microbial devices, such as those blending antibiotics into the material or through surface modification [11][12][13][14][15][16][17][18] . These approaches have multiple issues including coating delamination and cracking in the aggressive implant service environment [16] , localized cytotoxicity from anti-microbial coatings [16] , active compound depletion [17,18] , and most crucially, potential selection for anti-microbial resistance resulting from the selective pressures that antimicrobial killing strategies impose [19] .…”