3D nanofibrous bioactive glass scaffolds produced by one-step spinning process

Medeiros, Eudes L.G.; Gomes, D. S.; Santos, Adillys M. C.; Vieira, Rafaela H.; Lima, Isabela Lemos de; Rocha, Flaviana Soares; Castro-Filice, Letícia de Souza; Medeiros, Eliton S.; Neves, G. A.; Menezes, Romualdo Rodrigues

doi:10.1016/j.ceramint.2020.08.112

Cited by 19 publications

(18 citation statements)

References 58 publications

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“…A BG nanofibrous scaffold bioactivity was also studied by Medeiros et al [ 23 ]. In this study, 3D nanofibrous scaffolds of 68S and 63S BG were fabricated by SBS in a one-step process.…”

Section: Bone Regenerationmentioning

confidence: 99%

“… Main studies addressing ceramic nanofibers applied in bone regeneration applications over the last six years [ 23 , 55 , 56 , 74 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 ]. …”

Section: Figurementioning

confidence: 99%

“…In this context, ceramic nanofibers, notably those composed of bioactive glass and glass ceramics, present biological and chemical properties as well as the ability to mimic the hierarchical architecture of the ECM, depicting their great potential applications in the regeneration of bone tissue and wound healing [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…In centrifugal jet spinning, the spinning solution is placed in a rotating spinning head that is continuously fed at a certain flow rate, and, when the rotating speed reaches a critical value, the centrifugal force overcomes the surface tension of the spinning solution, resulting in the ejection of the solution [ 43 , 44 , 45 , 46 , 47 ]. The electrospinning (ES) technique is based on the generation of an electrical field between a solution placed in a capillary tube and a metal collector, and, when the electric field reaches a critical value, electrostatic repulsive forces overcome the surface tension of the polymer solution, producing a charged jet that results in the nanofibers’ formation [ 48 , 49 ]; and solution blow spinning (SBS), in turn, consists of a method in which the spinning solution is pumped through a matrix of concentric nozzles, where the solution passes through the inner nozzle and a pressurized air passes through the external nozzle, simultaneously, then, the high-velocity gas stream overcomes the surface tension of the solution, deforming it, and, during its journey to the collector, the nanofibers are produced by solvent evaporation [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, nanofibers with different and complex morphology, such as a porous, hollow, or core-shell structure, can be produced with these methods [ 39 , 51 ], expanding the use of these ceramic nanofibers in biomedical applications. Among the materials produced by these techniques, titania, calcium phosphate, alumina, zirconia, calcium silicate, silica, and bioactive glasses can be cited [ 23 , 45 , 48 , 50 , 52 , 53 , 54 , 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

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Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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Ceramic nanofibers have been shown to be a new horizon of research in the biomedical area, due to their differentiated morphology, nanoroughness, nanotopography, wettability, bioactivity, and chemical functionalization properties. Therefore, considering the impact caused by the use of these nanofibers, and the fact that there are still limited data available in the literature addressing the ceramic nanofiber application in regenerative medicine, this review article aims to gather the state-of-the-art research concerning these materials, for potential use as a biomaterial for wound healing and bone regeneration, and to analyze their characteristics when considering their application.

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“…A BG nanofibrous scaffold bioactivity was also studied by Medeiros et al [ 23 ]. In this study, 3D nanofibrous scaffolds of 68S and 63S BG were fabricated by SBS in a one-step process.…”

Section: Bone Regenerationmentioning

confidence: 99%

“… Main studies addressing ceramic nanofibers applied in bone regeneration applications over the last six years [ 23 , 55 , 56 , 74 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 ]. …”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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Three‐phase bio‐nanocomposite natural‐rubber‐based microfibers reinforced with cellulose nanowhiskers and 45S5 bioglass obtained by solution blow spinning

Silva,

Dias,

Zaszczyńska

et al. 2023

J of Applied Polymer Sci

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Aiming at biomedical applications, the present work developed a new bio‐nanocomposite fibrous mat based on natural rubber (NR) reinforced with 45S5 bioglass particles (BG) and cellulose nanowhiskers (CNW), which reveals excellent mechanical properties, good biocompatibility and bioactivity properties. Analyses of the specimens were conducted by means of morphological observations (SEM) and thermal analysis (TG/DTG), as well as mechanical tests used to verify the effect of the incorporation of BG particles and CNW on the ultimate properties of these flexible NR‐CWN/BG fibrous membranes. An SEM analysis revealed that all filaments possessed a ribbon‐like morphology, with increasing diameters as the BG concentration increased. This likely results from an increased viscosity of the solution used for fiber blowing. In comparison with neat NR fibrous mats, the ultimate mechanical properties of bio‐nanocomposites were significantly improved due to the presence of CNW and BG particles dispersed in the NR matrix. According to the TG/DTG analysis, the specimens' thermal stability was unaffected by the high BG content, and the thermal profiles were similar, with isoprene chains decomposition of the NR occurring between 350 and 450°C. In‐vitro analysis on fibroblasts confirmed that the bio‐nanocomposite fibrous mats are noncytotoxic. It was found that fibrous mats enhanced cellular growth and hold great promise for tissue engineering applications.

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Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

Montazerian,

Shearer,

Mauro

2023

Int J Ceramic Engine & Sci

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Both unwanted and induced crystallization can impact bioactivity, physical and mechanical properties of bioactive glasses (BGs). Uncontrolled crystallization has negative consequences, rendering BGs unreliable. However, by manipulating the type, size, shape, and quantity of crystals in BGs, plenty of opportunities arise for controlling, for example, mechanical properties and degradability, leading to unique applications and improved performance. Understanding crystallization is a key step in developing bioactive glasses and glass‐ceramics (BGCs), and both fundamental and experimental research can aid in the design of BGCs for processing and biological function. In this perspective, we discuss the sources of crystallization and how controlled crystallization facilitates the functionalization of bioactive scaffolds, hybrids, coatings, composites, cements, and fibers.

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3D nanofibrous bioactive glass scaffolds produced by one-step spinning process

Cited by 19 publications

References 58 publications

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Three‐phase bio‐nanocomposite natural‐rubber‐based microfibers reinforced with cellulose nanowhiskers and 45S5 bioglass obtained by solution blow spinning

Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

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