3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis

Ушенко, В. А.; Sdobnov, Anton; Syvokorovskaya, Anna; Dubolazov, A. V.; Vanchulyak, Oleh; Ушенко, А. Г.; Ushenko, Yu. A.; Gorsky, M. P.; Sidor, M. I.; Bykov, Alexander; Meglinski, Igor

doi:10.3390/photonics5040054

Cited by 62 publications

(64 citation statements)

References 57 publications

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“…The chiral nature of the optically anisotropic stromal region (optically active collagen fibers) of cervical tissue is the origin of the circular birefringence. In several reports , the circular birefringence has been discussed by studying polycrystalline films of biological tissue and fluids as diagnostic parameters for various types of disease through different techniques and analytical methods. The estimation of the polarization–correlation parameters based on the spatial frequency analysis of linear and circular birefringence have been reported from the histological sections of cervical tissues with different pathological condition .…”

Section: Resultsmentioning

confidence: 99%

“…This can be related with the fact that the linearly organized collagen strands get fragmented during the disease progression . Similar type of analysis has been performed over the diffuse tomograms of fluctuations of linear, linear‐45 and circular birefringence in connection with the diagnosis and differentiation of prostate cancer with good sensitivity and accuracy ranging from 74% to 92% . In the current study, the best diagnostic performance is achieved by using the diattenuation vector.…”

Section: Resultsmentioning

confidence: 99%

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Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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The mapping of diattenuation, polarizance and retardance vector (normalized Stokes vector) on Poincare sphere, evaluated from Mueller matrix of optically anisotropic stromal region of cervical tissues, is presented for cervical precancer detection and its staging. This reveals that the changes in the polarization states shown by these normalized Stokes vectors corresponds to the degradation of linearly arranged collagen fibers, breakage of the collagen cross links in the stromal region and change in the density of scattering sites when cervical cancer evolves. The distinct nature of real and imaginary parts of the refractive index for linear, linear-45 and circular polarization from the optically anisotropic stromal region underscore the various polarization structures of the connective tissue region which get modified during the pathological changes. It has been found that versatility of these vectors for normal and precancerous cervical tissue of various grades may be utilized as a key distinction for qualitative staging of cervical precancer tissue. Quantitative classification of precancerous stages of cervical precancer has been determined with 95%-100% sensitivity and 93%-100% specificity through the evaluation of linear and circular diattenuation, linear polarizance and linear birefringence from the components of the respective vectors. K E Y W O R D S cervical cancer, diattenuation vector, Mueller matrix, Poincare sphere, polarizance vector, retardance vector, stromal region

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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“…For most of the biological objects, the high level of optical radiation depolarization is typical. 18 As a result, determination of the polarization manifestations of various mechanisms of optical anisotropy is a complex and challenging task. To deal with this, the method of Mueller-matrix polar decomposition [19][20][21][22] is usually applied.…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fluids

Ушенко

Sdobnov

Mishalov

et al. 2019

J. Innov. Opt. Health Sci.

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Algorithms for reconstruction of linear and circular birefringence-dichroism of optically thin anisotropic biological layers are presented. The technique of Jones-matrix tomography of polycrystalline films of biological fluids of various human organs has been developed and experimentally tested. The coordinate distributions of phase and amplitude anisotropy of bile films and synovial fluid taken from the knee joint are determined and statistically analyzed. Criteria (statistical moments of 3rd and 4th orders) of differential diagnostics of early stages of cholelithiasis and septic arthritis of the knee joint with excellent balanced accuracy were determined. Data on the diagnostic efficiency of the Jones-matrix tomography method for polycrystalline plasma (liver disease), urine (albuminuria) and cytological smears (cervical cancer) are presented.

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“…This algorithm proved to be the most effective for analysis of the polycrystalline structure in the case of single scattering in biological layers. In this approximation, we first determined the Mueller matrix reconstruction algorithms for the coordinate distributions of the linear and circular birefringence and dichroism of biological tissues [27,28]. Statistical analysis of the obtained maps of optical anisotropy revealed objective criteria (statistical moments of the first to fourth order), which were used as the basis for differentiation of oncological changes in human organs (benign and malignant tumors of the prostate, myometrium, and endometrium) [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Differential Mueller matrix imaging of partially depolarizing optically anisotropic biological tissues

et al. 2019

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Since recently, a number of innovative polarization-based optical imaging modalities have been introduced and extensively used in various biomedical applications, with an ultimate aim to attain the practical tool for the optical biopsy and functional characterization of biological tissues. The techniques utilize polarization properties of light and Mueller matrix mapping of microscopic images of histological sections of biological tissues or polycrystalline films of biological fluids. The main drawback of currently developed laser polarimetry approaches and Mueller matrix mapping techniques is poor reproducibility of experimental data. This is due to azimuthal dependence of polarization and ellipticity values of most matrix elements to sample orientation in respect to incidence light polarization. Current study aims to generalize the methods of laser polarimetry for diagnosis of partially depolarizing optically anisotropic biological tissues. A method of differential Mueller matrix mapping for reconstruction of linear and circular birefringence and dichroism parameter distributions of partially depolarizing layers of biological tissues of different morphological structure is introduced and practically implemented. The coordinate distributions of the value of the first-order differential matrix elements of histological sections of brain tissue with spatially structured, optically anisotropic fibrillar network, as well as of parenchymatous tissue of the rectum wall with an "islet" polycrystalline structure are determined. Within the statistical analysis of polarization reproduced distributions of the averaged parameters of phase and amplitude anisotropy, the significant sensitivity of the statistical moments of the third and fourth orders to changes in the polycrystalline structure of partially depolarizing layers of biological tissue is observed. The differentiation of female reproductive sphere connective tissue is realized with excellent accuracy. The differential Mueller matrix mapping method for reconstruction of distributions of linear and circular birefringence and dichroism parameters of partially depolarizing layers of biological tissues of different morphological structures is proposed and substantiated. Differential diagnostics of changes in the phase (good balanced accuracy) and amplitude (excellent balanced accuracy) of the anisotropy of the partially depolarizing layers of the vagina wall tissue with prolapse of the genitals is realized. The maximum diagnostic efficiency of the first-order differential matrix method was demonstrated in comparison with the traditional methods of polarization and Mueller matrix mapping of histological sections of light-scattering biological tissues.

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3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis

Cited by 62 publications

References 57 publications

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fluids

Differential Mueller matrix imaging of partially depolarizing optically anisotropic biological tissues

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