3D-macroporous hybrid scaffolds for tissue engineering: Network design and mathematical modeling of the degradation kinetics

Mansur, Herman S.; Costa, Hermes S.; Mansur, Alexandra A.P.; Pereira, Marivalda M.

doi:10.1016/j.msec.2011.11.012

Cited by 18 publications

(9 citation statements)

References 53 publications

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“…Concerning to tissue engineering applications, synthetic materials have to be properly designed to match the mechanical properties to be a suitable alternative for the replacement of cortical or cancellous bones. Thus, the hybrids produced in this work, PVA/BaG and hybrids reinforced with CNT, presented yield stress values within the range normally reported for trabecular bone [19]. Also, as a highly porous material and with 3D architecture the developed hybrid systems showed a similar trend to the trabecular bone concerning the elastic modulus.…”

Section: Resultssupporting

confidence: 81%

“…To avoid redundancy with previous researches published by our group [18,19], the full details for the synthesis and characterization of the hybrids based on PVA and bioactive glass were not included in this study. Here, the major focus was given to the novelty associated with the effect on the mechanical properties by adding the chemically modified carbon nanotubes to the macroporous hybrid nanostructures.…”

Section: Synthesis Of Cnt Reinforced Hybrid Scaffoldsmentioning

confidence: 99%

“…Our group has been active on researching the synthesis and characterization of organic-inorganic hybrids in the system poly(vinyl alcohol)/bioactive glass (PVA/BaG) [12][13][14][15] to be used as scaffolds in tissue engineering applications. PVA/BaG have been prepared by the sol-gel process and the effect of PVA content, degree of hydrolysis, and synthesis conditions on properties of the porous scaffolds, and on degradation kinetics have been reported [16][17][18][19]. The results have clearly shown that it is possible to tailor the hybrids mechanical properties and degradation behavior by engineering the structure of the materials.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Behavior of Nanostructured Hybrids Based on Poly(Vinyl Alcohol)/Bioactive Glass Reinforced with Functionalized Carbon Nanotubes

Mansur

Pereira

Costa

2012

Journal of Nanomaterials

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This study reports the synthesis and characterization of novel tridimensional porous hybrids based on PVA combined with bioactive glass and reinforced by chemically functionalized carbon nanotubes (CNT) for potential use in bone tissue engineering. The functionalization of CNT was performed by introducing carboxylic groups in multiwall nanotubes. This process aimed at enhancing the affinity of CNTs with the water-soluble PVA polymer derived by the hydrogen bonds formed among alcohol (PVA) and carboxylic groups (CNT–COOH). In the sequence, the CNT–COOH (0.25 wt%) were used as the nanostructure modifier for the hybrid system based on PVA associated with the bioactive glass (BaG). The mechanical properties of the nanostructured hybrids reinforced with CNT–COOH were evaluated by axial compression tests, and they were compared to reference hybrid. The averaged yield stresses of macroporous hybrids were (2.3 ± 0.9) and (4.4 ± 1.0) MPa for the reference and the CNT reinforced materials, respectively. Moreover, yield strain and Young's modulus were significantly enhanced by about 30% for the CNT–COOH hybrids. Hence, as far as the mechanical properties are concerned, the results have clearly showed the feasibility of utilizing these new hybrids reinforced with functionalized CNT in repairing cancellous bone tissues.

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Section: Resultssupporting

confidence: 81%

Section: Synthesis Of Cnt Reinforced Hybrid Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanical Behavior of Nanostructured Hybrids Based on Poly(Vinyl Alcohol)/Bioactive Glass Reinforced with Functionalized Carbon Nanotubes

Mansur

Pereira

Costa

2012

Journal of Nanomaterials

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“…Lattice parameters a and c were calculated from peaks (300) and (002), respectively, using the standard hexagonal unit cell plane spacing relationship (Equation (3)) [4].

\frac{1}{d^{2}} = \frac{4}{3} (\frac{h^{2} + hk + k^{2}}{a^{2}}) + \frac{l^{2}}{c^{2}}

where, d is the distance between adjacent planes in the set of Miller indices (hkl).…”

Section: Methodsmentioning

confidence: 99%

Niobium-Doped Hydroxyapatite Bioceramics: Synthesis, Characterization and In Vitro Cytocompatibility

Capanema¹,

Mansur²,

Carvalho³

et al. 2015

Materials

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Doping calcium phosphates with ionic species can play an important role in biological responses promoting alkaline phosphatase activity, and, therefore inducing the generation of new bone. Thus, in this study, the synthesis of niobium-doped hydroxyapatite (Nb-HA) nanosize particles obtained by the precipitation process in aqueous media followed by thermal treatment is presented. The bioceramics were extensively characterized by X-ray diffraction, wavelength dispersive X-ray fluorescence spectrometry, Fourier transform infrared spectroscopy, scanning electron microscopy/energy dispersive X-ray spectroscopy analysis, transmission electron microscopy, atomic force microscopy and thermal analysis regarding their chemical composition, structure and morphology. The results showed that the precipitate dried at 110 °C was composed of amorphous calcium phosphate and HA, with polidisperse particles ranging from micro to nano dimensions. After the thermal treatment at 900 °C, the bioceramic system evolved predominantly to HA crystalline phase, with evident features of particle sintering and reduction of surface area. Moreover, the addition of 10 mol% of niobium salt precursor during the synthesis indicated the complete incorporation of the Nb(V) species in the HA crystals with detectable changes in the original lattice parameters. Furthermore, the incorporation of Nb ions caused a significant refinement on the average particle size of HA. Finally, the preliminary cytocompatibility response of the biomaterials was accessed by human osteoblast cell culture using MTT and resazurin assays, which demonstrated no cytotoxicity of the Nb-alloyed hydroxyapatite. Thus, these findings seem promising for developing innovative Nb-doped calcium phosphates as artificial biomaterials for potential use in bone replacements and repair.

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“…The weights obtained in each step of the process were used to calculate the swelling degree (SD) and degree of degradation (DD) of the hydrogels using eqs. and , respectively, as reported in the literature

SD true(% true) = true(true(W_{normals} - W_{0} true) / W_{0} true) \times 100 %

DD true(% true) = true(true(W_{0} - W_{f} true) / W_{0} true) \times 100 %

…”

Section: Methodsmentioning

confidence: 80%

Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose‐silver nanoparticle hybrids for wound dressing and epidermal repair

Capanema

Mansur

Carvalho

et al. 2017

J of Applied Polymer Sci

Self Cite

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Skin loss can be caused by accident, burn, trauma, chronic wounds, and diseases, which is severely aggravated by multidrug‐resistant bacterial infections. Soft hybrids based on biopolymers combined with silver nanoparticles (AgNPs) have potential applications as wound dressing supports and skin tissue repair. Thus, our study focused on the design, green synthesis, and comprehensive characterization of carboxymethyl cellulose (CMC–AgNP) nanocomposites for producing hydrogel membranes, with tunable physicochemical properties, cytocompatibility, and biocidal activity for potential application as wound dressing and skin repair. These nanocomposites were prepared using CMC with two degrees of carboxymethylation, distinct concentrations of citric acid (CA) crosslinker, and AgNPs by in situ chemical reduction, forming hybrid membranes by the solvent casting method. The results demonstrated that superabsorbent hydrogels were produced with swelling and degradation behaviors dependent on the concentration of CA crosslinker, degree of carboxymethylation of CMC, and content of AgNP in the matrices. Moreover, the Fourier transform infrared spectroscopy analysis evidenced that the CMC functional groups (e.g., COOH and OH) were directly involved in the chemical reactions for the formation of AgNPs and hydrogel crosslinking pathway. These nanocomposites were cytocompatible using in vitro 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyltetrazolium bromide cell viability assay with of human embryonic kidney cells. Conclusively, the CMC–AgNP nanohybrids demonstrated to be simultaneously non‐toxic combined with highly effective antibacterial activity against gram‐positive multi‐resistant wound/skin pathogens (Staphylococcus aureus) and moderate effect towards gram‐negative strains (Escherichia coli and Pseudomonas aeruginosa). © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45812.

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3D-macroporous hybrid scaffolds for tissue engineering: Network design and mathematical modeling of the degradation kinetics

Cited by 18 publications

References 53 publications

Mechanical Behavior of Nanostructured Hybrids Based on Poly(Vinyl Alcohol)/Bioactive Glass Reinforced with Functionalized Carbon Nanotubes

Mechanical Behavior of Nanostructured Hybrids Based on Poly(Vinyl Alcohol)/Bioactive Glass Reinforced with Functionalized Carbon Nanotubes

Niobium-Doped Hydroxyapatite Bioceramics: Synthesis, Characterization and In Vitro Cytocompatibility

Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose‐silver nanoparticle hybrids for wound dressing and epidermal repair

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