3D Functional Microgels: Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening (Adv. Mater. Technol. 5/2020)

Cai, Shuxiang; Chen, Yibao; Lai, Youbin; Yu, Haibo; Wang, Yuechao; Liu, Lianqing

doi:10.1002/admt.202070024

Cited by 3 publications

(5 citation statements)

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“…This approach combines the advantages of each methodology, allowing researcher to obtain microgels with complex morphology and well‐controlled size. [ 49 ]…”

Section: Considerations For Granular Inks: Formulation and Challengesmentioning

confidence: 99%

Programmable Granular Hydrogel Inks for 3D Bioprinting Applications

Ribeiro

Gaspar

Sobreiro‐Almeida

et al. 2023

Adv Materials Technologies

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Granular inks comprising jammed hydrogel unit building blocks are emerging as multiprogramable precursors for 3D/4D printing nonbulk hydrogel constructs. In addition to their injectability, they also exhibit high porosity when compared to bulk hydrogels, allowing more efficient nutrient transport and cell migration through the scaffold structure. Herein, the key steps in the production of these inks, from the fabrication of the microgels, the jamming process, and how fabrication affects final material properties, such as porosity, resolution, and fidelity is reviewed. In addition, the main techniques used for the stabilization of scaffolds after the printing process and the assessment of cell viability, in the case of bioinks, are meticulously discussed. Finally, the most recent studies in the application of granular hydrogels for different biomedical applications are highlighted. All in all, it is envisioned that 3D‐printed granular constructs will continue to evolve towards increasingly stimuli‐responsive platforms that may respond in a spatiotemporally controlled manner that matches that of user‐defined or biologically encoded processes.

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“…This approach combines the advantages of each methodology, allowing researcher to obtain microgels with complex morphology and well‐controlled size. [ 49 ]…”

Section: Considerations For Granular Inks: Formulation and Challengesmentioning

confidence: 99%

Programmable Granular Hydrogel Inks for 3D Bioprinting Applications

Ribeiro

Gaspar

Sobreiro‐Almeida

et al. 2023

Adv Materials Technologies

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“…The top priority of bottom-up tissue engineering is to construct functional module units, which are usually composed of microscale cell-carrying hydrogels (such as polyethylene glycol, collagen, polyethylene glycol diacrylate, and gelatin-methacrylic anhydride [9,[21][22][23]). At present, there are six methods commonly used to prepare cell microgel modules, including emulsification, microchannels, microfluidic technology, bioprinting technology, and the liquid bridge manufacturing module units method [24] (Table 1).…”

Section: Module Manufacturingmentioning

confidence: 99%

“…Millions of patients are suffering from tissue damage every year [9,10,112,114]. Although tissue transplantation can be used to treat these patients, its use is limited by a severe shortage of donor tissue.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…The history of tissue engineering can be traced back to the 1980s, when Professors Joseph P. Vacanti and Robert Langer first proposed the research and exploration of tissue engineering [5]. In the early stages, scientists successfully used tissue engineering technology to create human auricle cartilage with the skin of mice [4], which symbolizes that tissue engineering technology can form tissues and organs with complex three-dimensional spatial structures for clinical application [2,[8][9][10][11][12][13][14]. Current tissue engineering techniques can be used to reconstruct a variety of tissues, such as muscle, bone, cartilage, tendon, ligament, blood vessels and skin [13,15].…”

Section: Introductionmentioning

confidence: 99%

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Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects

Wang

Wen-ya

et al. 2021

Micromachines

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Tissue engineering provides a powerful solution for current organ shortages, and researchers have cultured blood vessels, heart tissues, and bone tissues in vitro. However, traditional top-down tissue engineering has suffered two challenges: vascularization and reconfigurability of functional units. With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed. In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described. After a critical overview of this technology, a discussion of practical challenges is provided, and future development prospects are proposed.

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“…Not surprisingly, much effort has been devoted to the development of material systems with a complex architecture and multicomponent composition, [ 2–6 ] where the existence of specific interfaces (between components within a material system, and between the system and its ambient environment) enhances desirable material characteristics and/or addresses the shortcomings that hinder the use of simpler, single‐component material platforms made of the same bulk materials. Examples of their use in wearable energy harvesting systems, [ 7–9 ] photocatalysis [ 10 ] and chemical catalysis, [ 11–14 ] hydrogen energy, [ 15,16 ] protecting coatings, [ 17 ] biosensors [ 18 ] and sensors, [ 19–22 ] nanomedicine, [ 23–26 ] water purification [ 27,28 ] and splitting, [ 29,30 ] biotechnology, [ 31–35 ] and space exploration [ 36–40 ] abound ( Figure ).…”

Section: Introductionmentioning

confidence: 99%