3D fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging at different stages of otosclerosis

Berrettini, Stefano; Lombardo, Francesco; Bruschini, Luca; Ciabotti, A; Canapicchi, R; Sara, De Cori; Daniele, De Marchi; Forlì, Francesca

doi:10.1007/s00405-018-5093-2

Cited by 2 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies reported on MRI findings in patients with otosclerosis ( Table 6 ). Two described increased signal intensity on MRI before and shortly after contrast administration ( 59 , 63 ). Two studies reported a correlation between enhancement and disease stage ( 60 , 63 ), while another study reported no correlation between enhancement and degree of hearing loss ( 74 ).…”

Section: Resultsmentioning

confidence: 99%

MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review

et al. 2021

View full text Add to dashboard Cite

Objective: Capillaries within the inner ear form a semi-permeable barrier called the blood-labyrinth barrier that is less permeable than capillary barriers elsewhere within the human body. Dysfunction of the blood-labyrinth barrier has been proposed as a mechanism for several audio-vestibular disorders. There has been interest in using magnetic resonance imaging (MRI) with intravenous gadolinium-based contrast agents (GBCA) as a marker for the integrity of the blood labyrinth barrier in research and clinical settings. This scoping review evaluates the evidence for using intravenous gadolinium-enhanced MRI to assess the permeability of the blood-labyrinth barrier in healthy and diseased ears.Methods: A systematic search was conducted of three databases: PubMed, EMBASE, CINAHL PLUS. Studies were included that used GBCA to study the inner ear and permeability of the blood-labyrinth barrier. Data was collected on MRI protocols used and inner ear enhancement patterns of healthy and diseased ears in both human and animal studies.Results: The search yielded 14 studies in animals and 53 studies in humans. In healthy animal and human inner ears, contrast-enhanced MRI demonstrated gradual increase in inner ear signal intensity over time that was limited to the perilymph. Signal intensity peaked at 100 min in rodents and 4 h in humans. Compared to controls, patients with idiopathic sudden sensorineural hearing loss and otosclerosis had increased signal intensity both before and shortly after GBCA injection. In patients with Ménière's disease and vestibular schwannoma, studies reported increased signal at 4 h, compared to controls. Quality assessment of included studies determined that all the studies lacked sample size justification and many lacked adequate control groups or blinded assessors of MRI.Conclusions: The included studies provided convincing evidence that gadolinium crosses the blood-labyrinth barrier in healthy ears and more rapidly in some diseased ears. The timing of increased signal differs by disease. There was a lack of evidence that these findings indicate general permeability of the blood-labyrinth barrier. Future studies with consistent and rigorous methods are needed to investigate the relationship between gadolinium uptake and assessments of inner ear function and to better determine whether signal enhancement indicates permeability for molecules other than gadolinium.

show abstract

Section: Resultsmentioning

confidence: 99%

MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The presence of hyperintensity and postcontrast enhancement would be good predictors of permeability changes of the blood-labyrinth barrier. 51,52 In different stages of otosclerotic involvement, the aforementioned labyrinthine disturbances might correlate with clinical parameters, such as disease duration and degree of cochlear damage, measured by bone-conduction thresholds. 52 Preliminary studies point toward the utility of imaging in the evaluation of candidates to medical treatment for active otospongiosis.…”

Section: Magnetic Resonance Imaging In Otosclerosismentioning

confidence: 99%

“…51,52 In different stages of otosclerotic involvement, the aforementioned labyrinthine disturbances might correlate with clinical parameters, such as disease duration and degree of cochlear damage, measured by bone-conduction thresholds. 52 Preliminary studies point toward the utility of imaging in the evaluation of candidates to medical treatment for active otospongiosis. In this context, evidence of demineralization of the cochlear endosteum in HRCT or MRI could support the use of drug therapy to prevent the onset or the progression of the disease, even in cases without audiometric repercussions.…”

Section: Magnetic Resonance Imaging In Otosclerosismentioning

confidence: 99%

Imaging Studies in Otosclerosis: An Up-to-date Comprehensive Review

Mangia

Coelho²,

Carvalho

et al. 2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Otosclerosis is a primary osteodystrophy of the otic capsule, frequently responsible for acquired hearing loss in adults. Although the diagnostic value of imaging investigations in otosclerosis is debatable, they might still be employed with different goals within the context of the disease. Objectives The present paper aims to review the most recent literature on the use of imaging studies in otosclerosis for the most varied purposes, from routine application and differential diagnosis to prognostic prediction and investigation of surgical failure. Data Synthesis The diagnosis of otosclerosis is usually clinical, but computed tomography (CT) is paramount in particular cases for the differential diagnosis. The routine use, however, is not supported by strong evidence. Even so, there is growing evidence of the role of this method in surgical planning and prediction of postoperative prognosis. In specific scenarios, for example when superior semicircular canal dehiscence (SSCD) syndrome is suspected or in surgical failure, CT is crucial indeed. Magnetic resonance imaging (MRI), however, has limited – although important – indications in the management of individuals with otosclerosis, especially in the evaluation of postoperative complications and in the follow-up of medical treatment in active ostosclerosis. Conclusion Imaging studies have a broad range of well-established indications in otosclerosis. Besides, although the routine use of CT remains controversial, the most recent papers have shed light into new potential benefits of imaging prior to surgery.

show abstract

3D fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging at different stages of otosclerosis

Cited by 2 publications

References 18 publications

MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review

MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review

Imaging Studies in Otosclerosis: An Up-to-date Comprehensive Review

Contact Info

Product

Resources

About