3D flow study in a mildly stenotic coronary artery phantom using a whole volume PIV method

Brunette, Jean; Mongrain, Rosaire; Laurier, Jean; Galaz, Ramses; Tardif, Jean‐Claude

doi:10.1016/j.medengphy.2008.02.012

Cited by 48 publications

(28 citation statements)

References 30 publications

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“…Nevertheless, the use of lower concentrated CM might be advantageous in terms of lower viscosity and consecutively lower injection pressure. Viscosity of CM has been shown to play an important role in the overall enhancement pattern (1,2,18,19). Aim of this study was to test the hypothesis that peak injection pressures and overall objective and subjective image quality using low concentrated CM (240 mg/mL) injected with high flow rates will be comparable to a standard injection protocol (CM: 300 mg/mL) in CCTA.…”

Section: Page 6 Of 28mentioning

confidence: 99%

Coronary CT angiography using low concentrated contrast media injected with high flow rates: Feasible in clinical practice

Mihl

Kok

Wildberger

et al. 2015

European Journal of Radiology

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Usage of low iodine concentration CM and injection with high flow rates is feasible. High flow rates (9 mL/s) of Iopromide 240 were safely injected without complications and should not be considered a drawback in clinical practice. No significant differences in peak pressure and image quality were found. This creates a doorway towards applicability of a broad variety in flow rates and IDRs and subsequently more individually tailored injection protocols.

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Section: Page 6 Of 28mentioning

confidence: 99%

Coronary CT angiography using low concentrated contrast media injected with high flow rates: Feasible in clinical practice

Mihl

Kok

Wildberger

et al. 2015

European Journal of Radiology

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show abstract

“…The geometric model used is an idealized model of a coronary artery (3.175 mm inner diameter, 10 cm length) presenting an eccentric stenosis with a 50% area reduction (16,17). Casts to create the lumen of the artery were made with a low melting point alloy (Cerrolow117 ™ , Cerro Metal Products).…”

Section: Model Preparationmentioning

confidence: 99%

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

et al. 2010

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Leukocytes play a pivotal role in the progression of atherosclerosis. A novel three dimensional in vitro asymmetric stenosis model was used to better investigate the role of local hemodynamics in the adhesion of leukocytes to an established plaque. The adhesion of a human promyelocytic cell line (NB4) on a human abdominal aortic endothelial cell (EC) monolayer was quantified. NB4 cells were circulated over TNF-α stimulated and non-stimulated ECs for 1 or 6 hrs at 1.25 or 6.25 dynes/cm 2 and compared to static conditions. Cytokine stimulation increased significantly endothelial cell expression of intercellular adhesion molecule and vascular cell adhesion molecule. Under static conditions, neutrophils adhered overall more than under flow, with decreased adhesion with increasing shear. Adhesion was significantly higher in the recirculation region distal to the stenosis than in the inlet. Preshearing the endothelial cells decreased the expression of cell adhesion molecules in inflamed endothelium and significantly decreased adhesion. However, the ratio of adhesion between the recirculation zone and the inlet increased, hence exhibiting an increased regional difference. This work suggests an important role for neutrophil-endothelial cell interactions in the atherosclerotic process, especially in wall shear gradient regions. This is important clinically, potentially helping to explain plaque stability.

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“…The eccentric stenosis www.intechopen.com geometry with a 50% occlusion (i.e. 50% area reduction, orthogonal to flow) has been chosen to represent a clinically relevant atherosclerotic lesion (Brunette et al, 2008;Wexler et al, 1996). The model measures 10 cm in length with an internal diameter of 3.175 mm, Figure 3.…”

Section: Asymmetric Stenosis Tissue Culture Modelmentioning

confidence: 99%

In Vitro Leukocyte Adhesion in Endothelial Tissue Culture Models Under Flow

Cooper¹,

Dick²,

Emmott³

et al. 2012

Biomedical Science, Engineering and Technology

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3D flow study in a mildly stenotic coronary artery phantom using a whole volume PIV method

Cited by 48 publications

References 30 publications

Coronary CT angiography using low concentrated contrast media injected with high flow rates: Feasible in clinical practice

Coronary CT angiography using low concentrated contrast media injected with high flow rates: Feasible in clinical practice

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

In Vitro Leukocyte Adhesion in Endothelial Tissue Culture Models Under Flow

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