2022
DOI: 10.1016/j.biomaterials.2022.121406
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3D direct writing egg white hydrogel promotes diabetic chronic wound healing via self-relied bioactive property

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Cited by 32 publications
(29 citation statements)
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“…The formation of the EWG0 hydrogel depended on the physical cross-linking with only weak binding between protein chains, giving water molecules easy access to the hydrogel interior and resulting in high expansibility. Moreover, it was found that the EWG0 hydrogel was gradually degraded and ruptured with extended soaking time, which was because the water molecules destroyed the three-dimensional structure with weak intermolecular forces [ 45 ]. It is well known that the degree of cross-linking directly affects the water absorption of a hydrogel [ 35 ].…”
Section: Resultsmentioning
confidence: 99%
“…The formation of the EWG0 hydrogel depended on the physical cross-linking with only weak binding between protein chains, giving water molecules easy access to the hydrogel interior and resulting in high expansibility. Moreover, it was found that the EWG0 hydrogel was gradually degraded and ruptured with extended soaking time, which was because the water molecules destroyed the three-dimensional structure with weak intermolecular forces [ 45 ]. It is well known that the degree of cross-linking directly affects the water absorption of a hydrogel [ 35 ].…”
Section: Resultsmentioning
confidence: 99%
“…The preparation and characterization of egg white hydrogel were conducted according to protocols in our previous study with minor modifications ( Chang et al, 2019 ; Guo et al, 2022 ). In previous studies, we demonstrated that the sodium hydroxide gel method has similar material and biological properties between different egg species (white-shell eggs, brown-shell eggs and duck eggs) ( Guo et al, 2022 ). Considering the consistency and cost of this experiment, EW was extracted from fresh white-shell eggs and fully shaken evenly with a vortex vibrator to form a uniform EW liquid.…”
Section: Methodsmentioning
confidence: 99%
“…SEWH (EWH soaked in DMEM for secondary cross-linking) and 3D-SEWH utilized intrinsic bioactive components to stimulate the activity of Fbs and ASCs in vitro. Furthermore, 3D-SEWH showed better wound healing effect and angiogenesis than SEWH (Guo et al, 2022). However, the efficacy and clinical translation of EWH alone are still limited compared to relatively mature ASCs therapies.…”
Section: Introductionmentioning
confidence: 99%
“…Studies involving egg whites have shown promise, and were originated from a treatment widely used in antiquity as a poultice for dressings on burns and wound healing [ 169 ]. Currently, the search for biodegradable, easily obtainable, and low-cost hydrogels has attracted the industry and pharmaceutical research.…”
Section: D-printed Materials At Different Stages Of Wound Healingmentioning
confidence: 99%