3D direct printing of composite bone scaffolds containing polylactic acid and spray dried mesoporous bioactive glass-ceramic microparticles

Saberi, Azadeh; Behnamghader, Aliasghar; Aghabarari, Behzad; Yousefi, A A; Majda, Dorota; Martı́nez-Huerta, M.V.; Mozafari, Masoud

doi:10.1016/j.ijbiomac.2022.02.067

Cited by 18 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deposits on PLA/MMT/ SrBG had a Ca/P = 1.56 (calcium-deficient HA) and of PLA/MMT/SrBG/nHA Ca/P = 1.82 (calcium rich HA). Scaffolds made from glass ceramic/PLA filaments were also found able to promote biomineralization, with larger and denser apatite formations in comparison with sparse sentiments on neat PLA [86], similar to those shown in Fig. 4a.…”

Section: In Vitro Biomineralizationsupporting

confidence: 70%

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

et al. 2023

View full text Add to dashboard Cite

In this work, the effect of two different types of bioactive coatings on the properties of 3D printed poly(lactic acid)/montmorillonite (PLA/MMT) nanocomposite scaffolds was examined. To improve their suitability for bone tissue engineering applications, the PLA nanocomposite scaffolds were coated with (i) ordered mesoporous Strontium bioglass (SrBG) and (ii) SrBG and nanohydroxyapatite (nHA) using a simple dip coating procedure. The effect of the coatings on the morphology, chemical structure, wettability and nanomechanical properties of the scaffolds was examined. The hydrophilicity of PLA nanocomposite scaffolds increased after the SrBG coating and increased even more with the SrBG/nHA coating. Moreover, in the case of PLA/MMT/SrBG/nHA 3D printed scaffolds, the elastic modulus increased by ~ 80% and the hardness increased from 156.9 ± 6.4 to 293.6 ± 11.3 MPa in comparison with PLA. Finally, the in vitro biocompatibility and osteogenic potential were evaluated using bone marrow-derived stem cells. The coating process was found to be a fast, economical and effective way to improve the biomineralization and promote the differentiation of the stem cells toward osteoblasts, in comparison with the neat PLA and the PLA/MMT nanocomposite scaffold. Graphical abstract

show abstract

Section: In Vitro Biomineralizationsupporting

confidence: 70%

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…A broad SiO 2 diffraction peak was observed between 20° and 30° (2 θ ) before and after mMBG impregnation with Genta, thereby indicating that mMBG is an amorphous structure [ 35 , 36 ]. After comparison with the database, mMBG observed the diffraction plane of CaSiO 3 at 29.42° (JCPD 45-0156) [ 37 , 38 ]. Then, after soaking 10 wt.% mMBG/CPC in Tris-buffer for 1 day, the main diffraction planes of HA, such as (002), (211), (310), and (222), can be observed (JCPD 09-0432) [ 39 ], indicating that the addition of mMBG did not affect the phase transition of the CPC reaction into the HA phase.…”

Section: Resultsmentioning

confidence: 99%

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Chu

Huang

et al. 2022

Biomimetics

View full text Add to dashboard Cite

Calcium phosphate cement (CPC) is similar to bone in composition and has plasticity, while mesoporous bioactive glass (MBG) has the advantage of releasing Si, which can promote osteogenic properties and drug loading capacity. A sol–gel-prepared MBG micro-powder (mMBG) and further impregnated antibiotic gentamicin sulfate (Genta@mMBG: 2, 3, and 4 mg/mL) antibiotic were added to CPC at different weight ratios (5, 10, and 15 wt.%) to study CPC’s potential clinical applications. Different ratios of mMBG/CPC composite bone cement showed good injectability and disintegration resistance, but with increasing mMBG addition, the working/setting time and compressive strength decreased. The maximum additive amount was 10 wt.% mMBG due to the working time of ~ 5 min, the setting time of ~ 10 min, and the compressive strength of ~51 MPa, indicating that it was more suitable for clinical surgical applications than the other groups. The 2Genta@mMBG group loaded with 2 mg/mL gentamicin had good antibacterial activity, and the 10 wt.% 2Genta@mMBG/CPC composite bone cement still had good antibacterial activity but reduced the initial release of Genta. 2Genta@mMBG was found to have slight cytotoxicity, so 2Genta@mMBG was composited into CPC to improve the biocompatibility and to endow CPC with more advantages for clinical application.

show abstract

“…Glass has been used as an osteo-inductive material for bone regeneration in orthopedic and dentistry applications for several years [ 46 , 47 ]. In addition, glass nanoparticles were included as a component of bio-inks to enhance bone tissue engineering [ 48 , 49 ]. In the present study, we combine the two factors, i.e., epigenetic modifier pretreatment and the culture surface, aiming to obtain the maximum differentiation efficiency.…”

Section: Discussionmentioning

confidence: 99%

Non-additive effect of the DNA methylation inhibitor, 5-Aza-dC, and glass as a culture surface on osteogenic differentiation

Alghfeli

Parambath

Eldeen

et al. 2022

Heliyon

View full text Add to dashboard Cite

3D direct printing of composite bone scaffolds containing polylactic acid and spray dried mesoporous bioactive glass-ceramic microparticles

Cited by 18 publications

References 46 publications

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Non-additive effect of the DNA methylation inhibitor, 5-Aza-dC, and glass as a culture surface on osteogenic differentiation

Contact Info

Product

Resources

About