3d Conformal Radiation Therapy for Palliative Treatment of Canine Nasal Tumors

Buchholz, J.; Hagen, R; Leo, Chiara; Ebling, Alessia; Roos, Małgorzata; Kaser‐Hotz, Barbara; Bley, Carla Rohrer

doi:10.1111/j.1740-8261.2009.01603.x

Cited by 37 publications

(42 citation statements)

References 19 publications

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“…). Two studies of dogs receiving hypofractionated radiation protocols showed that 79 to 81% of treated dogs presented with late stage tumours (Buchholz , Maruo et al . ); however, these treatment groups do not represent the entire presented population of dogs as hypofractionated protocols are commonly recommended for dogs with late stage tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Our median survival times of 114 days with medical palliation and 174 days for hypofractionated radiotherapy protocols were also comparable with previous studies (Mellanby et al . , Buchholz , Maruo et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Local lymph node involvement is reported in up to 24% of cases (Henry , Rassnick et al . , Buchholz , Maruo et al . ).…”

Section: Introductionmentioning

confidence: 99%

“…, Rassnick et al . , Turek , Buchholz , Kuehn ). Differential diagnoses include inflammatory rhinitis, aspergillosis and intranasal foreign bodies.…”

Section: Introductionmentioning

confidence: 99%

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Late presentation of canine nasal tumours in aUKreferral hospital and treatment outcomes

Mason¹,

Maddox²,

Lillis³

et al. 2013

J of Small Animal Practice

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Objectives To determine the computed tomographic stage of dogs with nasal tumours in a UK referral population, and whether stage, time to referral and treatment correlates with outcome. Methods Retrospective review of clinical records and computed tomography scans of dogs with nasal tumours. Results Dogs (n=78) presented to a referral practice in the UK with suspected nasal tumours are presented with more late stage tumours than dogs in the USA and Japan. Length of time from initial presentation to referral did not correlate with tumour stage at diagnosis. Median survival times for radiotherapy‐treated dogs in this population are equivalent to those previously reported for late stage nasal tumours. Clinical Significance Dogs with nasal tumours are presented late in the course of disease in the North West of England. Dogs with clinical signs consistent with a nasal tumour should have timely imaging and biopsy, in order to make prompt treatment decisions. Although survival times are comparable with previous reports and radiotherapy is a valid treatment option for dogs with late stage disease, better outcomes are likely to be achievable with earlier treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Late presentation of canine nasal tumours in aUKreferral hospital and treatment outcomes

Mason¹,

Maddox²,

Lillis³

et al. 2013

J of Small Animal Practice

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“…The reported prognostic factors are destruction of the cribriform plate [1], tumor type [1,27], tumor stage [1,3,4,9,11,27], age >10 years [11], regional lymph node or pulmonary metastasis [8], resolution of clinical signs after treatment [7,23], tumor regression [28], facial deformity [23], three or more treatments/week [30] and a cumulative minimum tumor dose of at least 37 Gy [30]. In regard to the stage in particular, various stage classifications have been reported, and lower stages resulted in longer survival than higher stages [1,3,4,9,11,27]. However, the present results and other hypofractionated protocols [7,18] also showed no significant difference between tumor stage and survival time; thus, it was thought that the hypofractionated protocol was inappropriate for early stages.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Study of Canine Nasal Tumor Treated with Hypofractionated Radiotherapy

Maruo

Shida

Fukuyama

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. The object of this study was to evaluate hypofractionated multiportal field and two-portion (rostral and caudal portions divided by the eyelid) radiation therapy for canine nasal tumors. Sixty-three dogs underwent multiportal hypofractionated radiation therapy. The radiation field was divided into rostral and caudal portions by the eyelid. Treatments were performed four times for 57 dogs. The median irradiation dose/fraction was 8 Gy (range, 5-10 Gy); the median total dose was 32 Gy (10-40 Gy). Improvement of clinical symptoms was achieved in 53 (84.1%) of 63 cases. Median survival time was 197 days (range, 2-1,080 days). Median survival times with and without destruction of the cribriform plate before radiotherapy were 163 and 219 days, respectively. There was no significant difference between them. No other factors were related to survival according to a univariate analysis. All radiation side effects, except one, were grade I according to the VRTOG classification. It was not necessary to treat any dogs for skin side effects. One dog (1.6%) developed an oronasal fistula 1 year after completion of radiation therapy. This radiation protocol may be useful in reducing radiation side effects in dogs with cribriform plate destruction.KEY WORDS: canine, hypofractionated radiotherapy, multiportal fields, nasal tumor, palliative.J. Vet. Med. Sci. 73(2): 193-197, 2011 Tumors involving the nasal cavity and nearby sinuses are uncommon in dogs, and they account for approximately 1% of all reported canine tumors [29]. Because nasal tumors metastasize rarely, late in the course of disease, therapy is directed at controlling localized disease [19]. Without treatment, the median survival time of dogs has been reported to be 1.5-4.1 months [22,24,30]. Surgery alone never prolongs survival time [16,22], but it may also deteriorate quality of life. In regard to chemotherapy, Langova et al. reported the effectiveness of alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam [14], though their sample size was small [14]. Radiation therapy is the treatment of choice [29], and reported survival times have ranged from 7. 4 -47.7 months [1-3, 8, 11-13, 17, 20, 21, 23, 27, 28, 30].Various radiation treatment protocols in veterinary medicine have been reported. For total dose increasing, 19 [11] or 21 [5] fractions at 3 Gy/fraction over 1 month have been used. Because this method requires frequent anesthesia and is expensive, it is a heavy burden on the dog and owner. Hypofractionated radiotherapy has been used to address these issues [7,18].Hypofractionated radiation therapy results in late side effects that are more severe than with fractionated radiation therapy; blindness was reported following radiation treatment of dogs with nasal tumors [7,18]. To address this, multiportal field and two-portions (rostral and caudal portions divided by the eyelid) radiotherapy (Fig. 1) have been used to deliver the radiation dose to the tumor and achieve a decreased dose to surrounding tissue and, thus, pr...

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Multimodal Therapy

BVSc¹,

Séguin²

2012

Veterinary Surgical Oncology

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3d Conformal Radiation Therapy for Palliative Treatment of Canine Nasal Tumors

Cited by 37 publications

References 19 publications

Late presentation of canine nasal tumours in aUKreferral hospital and treatment outcomes

Late presentation of canine nasal tumours in aUKreferral hospital and treatment outcomes

Retrospective Study of Canine Nasal Tumor Treated with Hypofractionated Radiotherapy

Multimodal Therapy

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