3D bioprinting of vasculature network for tissue engineering

Zhang, Yahui

doi:10.17077/etd.dglg1kaa

Cited by 3 publications

(4 citation statements)

References 112 publications

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“…The droplet diameter varies from 3 to 200 µm and uses frequencies from 1 Hz to 10 KHz [112]. In some studies that have used encapsulated cells with acoustic (bio)printing, cell viability was from 80% to 90% [126]. The throughput is very high with values reaching almost 100 000 drops per second [127].…”

Section: Inkjetmentioning

confidence: 99%

Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries

Makode,

Maurya,

Niknam

et al. 2024

Biofabrication

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Tissue engineering has emerged as a strategy for producing functional tissues and organs to treat diseases and injuries. Many chronic conditions directly or indirectly affect normal blood vessel functioning, necessary for material exchange and transport through the body and within tissue-engineered constructs. The interest in vascular tissue engineering is due to two reasons: 1) functional grafts can be used to replace diseased blood vessels, and 2) engineering effective vasculature within other engineered tissues enables connection with the host's circulatory system, supporting their survival. Among various practices, (bio)printing has emerged as a powerful tool to engineer biomimetic constructs. This has been made possible with precise control of cell deposition and matrix environment along with the advancements in biomaterials. (Bio)printing has been used for both engineering stand-alone vascular grafts as well as vasculature within engineered tissues for regenerative applications. In this review article, we discuss various conditions associated with blood vessels, the need for artificial blood vessels, the anatomy and physiology of different blood vessels, available 3D (bio)printing techniques to fabricate tissue-engineered vascular grafts and vasculature in scaffolds, and the comparison among the different techniques. We conclude our review with a brief discussion about future opportunities in the area of blood vessel tissue engineering.

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Section: Inkjetmentioning

confidence: 99%

Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries

Makode,

Maurya,

Niknam

et al. 2024

Biofabrication

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“…Moreover, embedding such channels inside the tissue constructs has relied on the use of sacrificial and fugitive bioinks, increasing the complexity and time of fabrication. 7,8 For example, Miller et al 9 did a vascular casting process where they printed three-dimensional (3D) filament networks of carbohydrate glass based on sacrificial inks glucose. The methods put several constraints on the type of materials that can be fabricated as well as limit the resolution of the architecture of the microchannels.…”

Section: Introductionmentioning

confidence: 99%

“…Another disadvantage of most common bioprinting techniques is the height of each of the layers is pre-set restricting the height of sacrificial ink whereas increasing the height of fugitive ink individually may result in occlusion of lumen when detached. 7,10,11 In microfluidic applications, polydimethylsiloxane (PDMS) devices with internal channels 12 were fabricated by 3D printing an acrylonitrile butadiene styrene (ABS) channel, inserting the same into liquid PDMS, curing of PDMS followed by dissolution of ABS in acetone, leaving the channel behind. However, the process is cumbersome and not versatile for different materials.…”

Section: Introductionmentioning

confidence: 99%

Force modeling to develop a novel method for fabrication of hollow channels inside a gel structure

Barua

Giria

Datta

et al. 2019

Proc Inst Mech Eng H

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Fabrication of hollow channels with user-defined dimensions and patterns inside viscoelastic, gel-type materials is required for several applications, especially in biomedical engineering domain. These include objectives of obtaining vascularized tissues and enclosed or subsurface microfluidic devices. However, presently there is no suitable manufacturing technology that can create such channels and networks in a gel structure. The advent of three-dimensional bioprinting has opened new possibilities for fabricating structures with complex geometries. However, application of this technique to fabricate internal hollow channels in viscoelastic material has not been yet explored to a great extent. In this article, we present the theoretical modeling/background of a proposed manufacturing paradigm through which hollow channels can be conveniently fabricated inside a gel structure. We propose that a tip connected to a robotic arm can be moved in X-, Y-, and Z-axis as per the desired design. The tip can be moved by a magnet or mechanical force. If the tip is further trailed with porous tube and moved inside the viscoelastic material, corresponding internal channels can be fabricated. To achieve this, however, force modeling to understand the forces that will be required to move the tip inside viscoelastic material should be known and understood. Therefore, in our first attempt, we developed the computational force modeling of the tip movement inside gels with different viscoelastic properties to create the channels.

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“…The efficacy of conduits to support diffusion process was evaluated through perfusion and permeability experiments. Cell viability was 84% after seven days of perfusion culture demonstrating the potential of this method[90,91]. To enhance the mechanical properties of vascular conduits, Dolati et al demonstrated multi-walled carbon nano-tube (MWCNT) reinforcement (seeFigs.…”

mentioning

confidence: 98%

Bioprinting for vascular and vascularized tissue biofabrication

2017

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Biofabrication of living tissues and organs at the clinically-relevant volumes vitally depends on the integration of vascular network. Despite the great progress in traditional biofabrication approaches, building perfusable hierarchical vascular network is a major challenge. Bioprinting is an emerging technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision, which holds a great promise in fabrication of vascular or vascularized tissues for transplantation use. Although a great progress has recently been made on building perfusable tissues and branched vascular network, a comprehensive review on the state-of-the-art in vascular and vascularized tissue bioprinting has not reported so far. This contribution is thus significant because it discusses the use of three major bioprinting modalities in vascular tissue biofabrication for the first time in the literature and compares their strengths and limitations in details. Moreover, the use of scaffold-based and scaffold-free bioprinting is expounded within the domain of vascular tissue fabrication.

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3D bioprinting of vasculature network for tissue engineering

Cited by 3 publications

References 112 publications

Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries

Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries

Force modeling to develop a novel method for fabrication of hollow channels inside a gel structure

Bioprinting for vascular and vascularized tissue biofabrication

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