3D Bioprinting of cardiac tissue and cardiac stem cell therapy

Alonzo, Matthew; Kumar, Shweta; Roman, Brian B.; Tasnim, Nishat; Joddar, Binata

doi:10.1016/j.trsl.2019.04.004

Cited by 120 publications

(135 citation statements)

References 131 publications

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“…Inkjet bioprinting is a rapid and large-scale fabrication technique that has been adapted from the inkjet printing technology to print living cells by desktop inkjet printers [76] (Figure 3a). Currently, many studies utilize inkjet bioprinting to construct various engineered tissues with different kinds of living cells [77][78][79]. In addition, inkjet bioprinting can rapidly fabricate tissue-like structures with intricate hierarchical architectures by the utilization of the controlled dropwise deposition of cell-laden bioinks [79].…”

Section: D Bioprinting Methods In Fabrication Of Vascular Networkmentioning

confidence: 99%

3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication

et al. 2020

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Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as well as the removal of waste products. Fabrication of tissue-engineered bone constructs with functional vascular networks has great potential for biomimicking nature bone tissue in vitro and enhancing bone regeneration in vivo. Over the past decades, many approaches have been applied to fabricate biomimetic vascularized tissue-engineered bone constructs. However, traditional tissue-engineered methods based on seeding cells into scaffolds are unable to control the spatial architecture and the encapsulated cell distribution precisely, which posed a significant challenge in constructing complex vascularized bone tissues with precise biomimetic properties. In recent years, as a pioneering technology, three-dimensional (3D) bioprinting technology has been applied to fabricate multiscale, biomimetic, multi-cellular tissues with a highly complex tissue microenvironment through layer-by-layer printing. This review discussed the application of 3D bioprinting technology in the vascularized tissue-engineered bone fabrication, where the current status and unique challenges were critically reviewed. Furthermore, the mechanisms of vascular formation, the process of 3D bioprinting, and the current development of bioink properties were also discussed.

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Section: D Bioprinting Methods In Fabrication Of Vascular Networkmentioning

confidence: 99%

3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication

et al. 2020

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“…iPSCs derived from the peripheral tissues of patients with disease specific mutations are a valuable tool to study the cardiac pathophysiology and drug development. Cardiac tissues were biofabricated using hydrogels and supporting cells such as cardiomyocytes, endothelial cells, smooth muscle cells, and fibroblasts[ 109 , 110 ]. The cells were cocultured and engineered to resemble their natural physiological microenvironment and recapitulate coordinated contractile and electrophysiological interactions with the ECM and heterogeneous cell types that make up the myocardial tissue environment[ 111 ].…”

Section: Application Of Bioprinted Ipscs In Healthcarementioning

confidence: 99%

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Soman¹,

Vijayavenkataraman²

2024

IJB

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Induced pluripotent stem cell (iPSC) technology and advancements in three-dimensional (3D) bioprinting technology enable scientists to reprogram somatic cells to iPSCs and 3D print iPSC-derived organ constructs with native tissue architecture and function. iPSCs and iPSC-derived cells suspended in hydrogels (bioinks) allow to print tissues and organs for downstream medical applications. The bioprinted human tissues and organs are extremely valuable in regenerative medicine as bioprinting of autologous iPSC-derived organs eliminates the risk of immune rejection with organ transplants. Disease modeling and drug screening in bioprinted human tissues will give more precise information on disease mechanisms, drug efficacy, and drug toxicity than experimenting on animal models. Bioprinted iPSC-derived cancer tissues will aid in the study of early cancer development and precision oncology to discover patient-specific drugs. In this review, we present a brief summary of the combined use of two powerful technologies, iPSC technology, and 3D bioprinting in health-care applications.

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“…Widely used materials for scaffolds include decellularized extracellular matrix components and many synthetic and natural biomaterials. Bioprinting technologies can be potentially useful for the fabrication of a wide variety of tissues such as composite tissues, vascular tissues, lung, neural, pancreas, brain, bone, cancer, cardiac, cartilage, heart valve, liver, retinal, skin, and others[ 1 - 5 , 7 , 8 , 15 , 25 ]. In addition, there are different goals of using bioprinting in pharmaceutical researches such as developing drugs against cancer and other diseases[ 13 - 17 ].…”

Section: Living Cells Printingmentioning

confidence: 99%

Software for Bioprinting

Pakhomova¹,

Popov²,

Maltsev³

et al. 2024

IJB

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The bioprinting of heterogeneous organs is a crucial issue. To reach the complexity of such organs, there is a need for highly specialized software that will meet all requirements such as accuracy, complexity, and others. The primary objective of this review is to consider various software tools that are used in bioprinting and to reveal their capabilities. The sub-objective was to consider different approaches for the model creation using these software tools. Related articles on this topic were analyzed. Software tools are classified based on control tools, general computer-aided design (CAD) tools, tools to convert medical data to CAD formats, and a few highly specialized research-project tools. Different geometry representations are considered, and their advantages and disadvantages are considered applicable to heterogeneous volume modeling and bioprinting. The primary factor for the analysis is suitability of the software for heterogeneous volume modeling and bioprinting or multimaterial three-dimensional printing due to the commonality of these technologies. A shortage of specialized suitable software tools is revealed. There is a need to develop a new application area such as computer science for bioprinting which can contribute significantly in future research work.

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3D Bioprinting of cardiac tissue and cardiac stem cell therapy

Cited by 120 publications

References 131 publications

3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication

3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Software for Bioprinting

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