3D bioprinting in cardiac tissue engineering

Wang, Zihan; Wang, Ling; Li, Ting; Liu, Sitian; Guo, Baolin; Huang, Wenhua; Wu, Yaobin

doi:10.7150/thno.61621

Cited by 82 publications

(83 citation statements)

References 190 publications

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“…Tissue-engineered scaffolds play a key role in cardiac tissue engineering in that they provide a support framework for cells that can promote cell adhesion, proliferation, and differentiation . The ideal tissue-engineered scaffold should mimic the natural extracellular matrix structure with good mechanical properties, biocompatibility, electrical conductivity, and nontoxic products after degradation to achieve dynamic cardiac function. , There are numerous techniques used to prepare scaffolds, and the commonly used methods include freeze-drying, soft lithography, decellularization, 3D bioprinting, and electrospinning methods.…”

Section: Preparation Methods Of the Cardiac Patch Scaffoldmentioning

confidence: 99%

Recent Advances in Cardiac Patches: Materials, Preparations, and Properties

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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Cardiac patches are biomaterials that can be used for transplantation and repair of damaged myocardium by combining seed cells with the ability to form cardiomyocytes and suitable scaffold materials. On the one hand, they provide temporary support to the infarcted area, and on the other hand, they repair the damaged myocardium by delivering cells or bioactive factors to integrate with the host, which have gradually become a hot research topic in recent years. This paper summarizes the structural properties of natural myocardium and reviews the recent research progress of cardiac patches, including the seed cells and scaffold materials used in patch preparation, as well as the main methods of scaffold preparation and the structure properties of various scaffolds. In addition, a comprehensive analysis of the problems faced in the clinical implementation of cardiac patches is presented. Finally, we look forward to the development of cardiac patches and point out that precisely tunable anisotropic tissue engineering scaffolds close to natural myocardial tissue will become an important direction for future research.

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Section: Preparation Methods Of the Cardiac Patch Scaffoldmentioning

confidence: 99%

Recent Advances in Cardiac Patches: Materials, Preparations, and Properties

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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“…Applications of 3D printing have also expanded into full heart and chamber models (Lee et al 2019 ; Wang et al 2021 ). However, the field still has a long way to go before regularly using these models for in vitro testing.…”

Section: State-of-the-art Of In Vitro Tissue Modelsmentioning

confidence: 99%

3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives

et al. 2022

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The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro models of complex human tissues. Offering versatile and precise control over the cell population, extracellular matrix (ECM) deposition, dynamic microenvironment, and sophisticated microarchitecture, which is desired for the in vitro modeling of complex tissues, 3D bio-printing is a rapidly growing technology to be employed in the field. In this review, we will discuss the recent advancement of printing techniques and bio-ink sources, which have been spurred on by the increasing demand for modeling tactics and have facilitated the development of the refined tissue models as well as the modeling strategies, followed by a state-of-the-art update on the specialized work on cancer, heart, muscle and liver. In the end, the toxicological modeling strategies, substantial challenges, and future perspectives for 3D printed tissue models were explored.

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“…Other issues around the use of bioprinted constructs include the lack of standardized methods across these systems, the need of further improved image acquisition with high resolution, and costs. For a more in-depth review about bioprinting in cardiac tissue engineering, we direct the readers to other reviews [ 68 , 171 , 182 , 183 ].…”

Section: Implementation Of Biofabrication Tools For Cardiac Tissue En...mentioning

confidence: 99%

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Häneke

Sahara

2022

IJMS

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The human heart has the least regenerative capabilities among tissues and organs, and heart disease continues to be a leading cause of mortality in the industrialized world with insufficient therapeutic options and poor prognosis. Therefore, developing new therapeutic strategies for heart regeneration is a major goal in modern cardiac biology and medicine. Recent advances in stem cell biology and biotechnologies such as human pluripotent stem cells (hPSCs) and cardiac tissue engineering hold great promise for opening novel paths to heart regeneration and repair for heart disease, although these areas are still in their infancy. In this review, we summarize and discuss the recent progress in cardiac tissue engineering strategies, highlighting stem cell engineering and cardiomyocyte maturation, development of novel functional biomaterials and biofabrication tools, and their therapeutic applications involving drug discovery, disease modeling, and regenerative medicine for heart disease.

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3D bioprinting in cardiac tissue engineering

Cited by 82 publications

References 190 publications

Recent Advances in Cardiac Patches: Materials, Preparations, and Properties

Recent Advances in Cardiac Patches: Materials, Preparations, and Properties

3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives

Progress in Bioengineering Strategies for Heart Regenerative Medicine

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