3D Bioprinted Hydroxyapatite or Graphene Oxide Containing Nanocellulose‐Based Scaffolds for Bone Regeneration

Lafuente‐Merchan, Markel; Ruiz‐Alonso, Sandra; García‐Villén, Fátima; Zabala, Alaitz; Retana, Ana M. Ochoa de; Gallego, Idoia; Burgo, Laura Sáenz del; Pedraz, José Luís

doi:10.1002/mabi.202200236

Cited by 14 publications

(6 citation statements)

References 73 publications

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“…In addition, it can be chemically modified and has been widely used for biomedical applications in the last few years. 44 Incorporating GO with gelatin matrix can improve their mechanical properties and creates additional pore structures for better diffusion of nutrients and waste products. 26 Due to the excellent biocompatibility and robust physical properties, the combination formulation of gelatin and GO presents a viable choice for the fabrication of wound dressing.…”

Section: Discussionmentioning

confidence: 99%

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Qian¹,

Shen²,

Wang³

et al. 2023

IJN

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Purpose We aimed to develop an antioxidant dressing material with pro-angiogenic potential that could promote wound healing. Gelatin (Gel) was selected to improve the biocompatibility of the scaffolds, while graphene oxide (GO) was added to enhance their mechanical property. The loaded N-Acetyl cysteine (NAC) was performing the effect of scavenging reactive oxygen species (ROS) at the wound site. Materials and Methods The physicochemical and mechanical properties, NAC releases, and biocompatibility of the NAC-GO-Gel scaffolds were evaluated in vitro. The regeneration capability of the scaffolds was systemically investigated in vivo using the excisional wound-splinting model in mice. Results The NAC-GO-Gel scaffold had a stronger mechanical property and sustainer NAC release ability than the single Gel scaffold, which resulted in a better capacity for cell proliferation and migration. Mice wound-splinting models revealed that the NAC-GO-Gel scaffold effectively accelerated wound healing, promoted re-epithelialization, enhanced neovascularization, and reduced scar formation. Conclusion The NAC-GO-Gel scaffold not only promotes wound healing but also reduces scar formation, showing a great potential application for the repair of skin defects.

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Section: Discussionmentioning

confidence: 99%

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Qian¹,

Shen²,

Wang³

et al. 2023

IJN

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“…Creating a HAp-based composition of the scaffolds with polymers improves the mechanical properties and enables the production of multilayer compositions for 3D printing [14,[54][55][56]58]. To increase the mechanical properties of 3D-printed HAp/polymeric biomaterials, in some research, graphene oxide was added [57].…”

Section: Status Of Calcium Phosphate Biomaterials In 3d (Bio)printing...mentioning

confidence: 99%

Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

Tolmacheva,

Bhattacharyya,

Noh

2024

Biomimetics

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Three-dimensional bioprinting is a promising technology for bone tissue engineering. However, most hydrogel bioinks lack the mechanical and post-printing fidelity properties suitable for such hard tissue regeneration. To overcome these weak properties, calcium phosphates can be employed in a bioink to compensate for the lack of certain characteristics. Further, the extracellular matrix of natural bone contains this mineral, resulting in its structural robustness. Thus, calcium phosphates are necessary components of bioink for bone tissue engineering. This review paper examines different recently explored calcium phosphates, as a component of potential bioinks, for the biological, mechanical and structural properties required of 3D bioprinted scaffolds, exploring their distinctive properties that render them favorable biomaterials for bone tissue engineering. The discussion encompasses recent applications and adaptations of 3D-printed scaffolds built with calcium phosphates, delving into the scientific reasons behind the prevalence of certain types of calcium phosphates over others. Additionally, this paper elucidates their interactions with polymer hydrogels for 3D bioprinting applications. Overall, the current status of calcium phosphate/hydrogel bioinks for 3D bioprinting in bone tissue engineering has been investigated.

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“…Notably, compared to the prior study, the use of allograft bone particles was found to contribute to enhanced cell viability during and after printing, for 90% viability for up to 28 days in vitro. Moreover, the potential for graphene oxide additives to improve bioink mechanical properties was explored in several applications with alginate- [149], gelatin- [150], alginate/gelatin blend-, and gellan gum-based hydrogels [151]. Generally, the addition of graphene oxide was found to contribute mechanical strength and improve the bioink printing performance, and in several applications, was tuned in accordance with the hydrogel with chemical modifications to function in targeted drug delivery and tumor suppression.…”

Section: Nanomaterials Composites For Bone Bioprintingmentioning

confidence: 99%

Nanocomposite Bioprinting for Tissue Engineering Applications

Loukelis

Helal

Mikos

et al. 2023

Gels

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Bioprinting aims to provide new avenues for regenerating damaged human tissues through the controlled printing of live cells and biocompatible materials that can function therapeutically. Polymeric hydrogels are commonly investigated ink materials for 3D and 4D bioprinting applications, as they can contain intrinsic properties relative to those of the native tissue extracellular matrix and can be printed to produce scaffolds of hierarchical organization. The incorporation of nanoscale material additives, such as nanoparticles, to the bulk of inks, has allowed for significant tunability of the mechanical, biological, structural, and physicochemical material properties during and after printing. The modulatory and biological effects of nanoparticles as bioink additives can derive from their shape, size, surface chemistry, concentration, and/or material source, making many configurations of nanoparticle additives of high interest to be thoroughly investigated for the improved design of bioactive tissue engineering constructs. This paper aims to review the incorporation of nanoparticles, as well as other nanoscale additive materials, to printable bioinks for tissue engineering applications, specifically bone, cartilage, dental, and cardiovascular tissues. An overview of the various bioinks and their classifications will be discussed with emphasis on cellular and mechanical material interactions, as well the various bioink formulation methodologies for 3D and 4D bioprinting techniques. The current advances and limitations within the field will be highlighted.

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3D Bioprinted Hydroxyapatite or Graphene Oxide Containing Nanocellulose‐Based Scaffolds for Bone Regeneration

Cited by 14 publications

References 73 publications

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

Nanocomposite Bioprinting for Tissue Engineering Applications

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