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Abstract

Orntide acetate was found to be an effective LHRH antagonist with a rapid onset of pharmacological action and a short biological half-life. Administration of a single dose of liquid Orntide or Orntide microspheres, resulted in rapid testosterone suppression without an initial elevation, as seen with LHRH superagonists. However, combined administration of Orntide and Leuprolide did not have an effect on the initial testosterone elevation in rats.

Acute gonadotropin-releasing hormone agonist treatment enhances extinction memory in male rats

“…For experiment 1, the animals were injected subcutaneously with either 0.9% saline (vehicle; Sigma-Aldrich, St. Louis, MO) or LEU (1.2mg/kg; Sigma-Aldrich, St. Louis, MO) thirty minutes before the extinction session on day 2. The 1.2mg/kg dose was selected based on results from our dose response test to confirm this was the lowest dose to induce the T surge, as well as previous reports examining the castration effects of LEU with chronic administration at doses from 1–3mg/kg for days to months (Ichikawa et al, 1988; Kostanski et al, 2000; Yamamoto et al, 2004). On day 3 for both experiments, the animals were returned to the chamber and presented with 3 CS-alone trials for the extinction recall test.…”