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Rossi-Ferragut, Lia Mara; Iaconelli, Assumpto; Aoki, Tsutomu; Rocha, C.C.; Santos, Daniela Regina dos; Pasqualotto, Fábio Firmbach; Borges, Edson

doi:10.1023/a:1021286119979

Cited by 16 publications

(3 citation statements)

References 32 publications

(32 reference statements)

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“…This hypothesis is further substantiated by the present observation that GH administration in this group of patients did not only improve the morphological quality of the oocytes obtained, but it also increased the total number of fertilized oocytes (zygotes), that of normal zygotes and that of high-quality embryos, as judged by their morphological appearance. Among these characteristics, that of the zygote quality seems to be of particular importance, since it was previously shown that zygote pronuclear morphology is related not only with IVF clinical outcomes ( 25 – 28 ) and the rate of embryo development to the blastocyst stage ( 27 ), but also with the normal ploidy of the resulting blastocysts ( 29 – 31 ). When used in combination with further evaluation of embryo morphology during subsequent stages of preimplantation development, the prognostic value of zygote morphology, as to the probability of establishing a normal pregnancy, was further enhanced ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Oocytes were attributed one of the four cumulative scores, from A (the best one) to D (the worst one), taking into account the oocyte shape, cytoplasmic granularity, the presence of intracytoplasmic vacuoles, the form of the zona pellucida and the perivitelline space, and the size and morphology of the first polar body ( 37 ). Zygotes and cleaving embryos ( Figure 1 ) were scored as described previously ( 25 – 28 , 32 ). Briefly, cleaving embryos were scored according to the number of cells, the shape and regularity of the cells, and the volume occupied by anucleate fragments ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

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The Effect of GH Administration on Oocyte and Zygote Quality in Young Women With Repeated Implantation Failure After IVF

Galán-Lázaro¹,

Conde-López²,

Chiara-Rapisarda

et al. 2020

Front. Endocrinol.

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Growth hormone (GH) has been shown to improve implantation and live birth rates in women of >40 years of age treated by in vitro fertilization (IVF). This effect was initially attributed to a GH effect on oocyte quality, but later studies showed that GH can also improve uterine receptivity for embryo implantation. As to younger women with previous failures of embryo implantation after IVF, data reported in the literature are ambiguous. This retrospective study focused on this latter category of women, comparing the numbers and morphological appearance of oocytes recovered from women with two previous IVF failures, aged between 30 and 39 years and treated with GH, with a comparable group of women without GH treatment. These results were complemented with the analysis of morphological markers of zygote and embryo quality and IVF clinical outcomes in both groups. The oocytes, zygotes and embryos from women treated with GH showed better morphological scores, and their uterine transfer resulted in more implantations, pregnancies and live births, as compared with the untreated group. It is concluded that the improvement of IVF outcomes in women with previous repeated IVF failures by exogenous GH administration is, at least partly, related to an increase in oocyte developmental potential. The statistically evident improvement of oocyte and embryo quality is the main finding of this study. Its weakness is its retrospective nature.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Effect of GH Administration on Oocyte and Zygote Quality in Young Women With Repeated Implantation Failure After IVF

Galán-Lázaro¹,

Conde-López²,

Chiara-Rapisarda

et al. 2020

Front. Endocrinol.

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“…Among the treatment modalities offered to infertile couples, those utilizing assisted reproductive technologies (ART) are associated with the highest success rates [2]. ART procedures involve retrieval of oocyte(s) from a woman's ovaries, their fertilization in vitro in a laboratory, and the return of the resulting embryo to the woman's body or donation to another woman [3]. More than 99% of all ART procedures involves the transfer of the resulting embryos into the woman's uterus through cervix [2], and are termed in vitro fertilization-embryo transfer (IVF-ET).…”

Section: Infertility and Assisted Reproductive Technologies (Art)mentioning

confidence: 99%

Perspectives on Emerging Biomarkers for Non-Invasive Assessment of Embryo Viability in Assisted Reproduction

Aydıner¹,

Yetkin²,

Seli³

2010

CMM

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A key step in assisted reproduction is the assessment of embryo viability in order to identify the embryo(s) most likely to result in pregnancy. Currently used embryo assessment systems are largely based on morphology and cleavage rate. While these systems have been pivotal in improving implantation and pregnancy rates and reducing multiple gestations, their precision is still insufficient. The limitations of strategies based on morphology have led to the investigation of adjunctive technologies for non-invasive assessment of embryo viability in assisted reproduction. These include the measurement of glucose, pyruvate, or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of ART cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer become an increasingly more important goal for reproductive medicine.

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The value of pronuclear scoring for the success of IVF and ICSI-cycles

Ludwig

Werner

Diedrich

et al. 2005

Arch Gynecol Obstet

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Abstract: PN classification associated with transfer day morphology is valuable additional noninvasive criterion for elective embryo transfer, mainly in the cases with severe male factor.

Cited by 16 publications

References 32 publications

The Effect of GH Administration on Oocyte and Zygote Quality in Young Women With Repeated Implantation Failure After IVF

The Effect of GH Administration on Oocyte and Zygote Quality in Young Women With Repeated Implantation Failure After IVF

Perspectives on Emerging Biomarkers for Non-Invasive Assessment of Embryo Viability in Assisted Reproduction

The value of pronuclear scoring for the success of IVF and ICSI-cycles

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