395 Age Influencing Liver Stiffness Measurements in Chinese Male General Populations

Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals

“…38 In contrast, several studies have shown a significant increase of LSM in apparently healthy individuals with hepatic steatosis on ultrasound as compared with those without steatosis. 1,8,25,39,40 In this large diverse study population, although higher mean LSM values were noted in individuals with steatosis (Table 1) on regression analysis, ultrasound-detected steatosis had no effect on LSM in individuals examined by a M or XL probe. Notably, however, the degree of liver steatosis diagnosed by ultrasound was not determined in the provided data set.…”

“…Since the introduction of TE in 2003, several studies have confirmed its role in the identification of different stages of liver fibrosis compared with the reference gold standard of liver biopsy in different liver diseases. The currently recognized normal values for TE-acquired LSM have been derived from a number of studies, [1][2][3][4][5][6][7][8][9][10][11][12][13] the first of which was reported by Corpechot et al 5 and evaluated the influence of sex on LSM. Other studies have been conducted in different populations, and the currently proposed 95th percentile of TE (range, 6.8-8.4 kPa) overlaps with the early stage of fibrosis.…”

Larger biopsies evaluation of transient elastography for detecting advanced fibrosis in patients with compensated chronic hepatitis B

“…Cutoffs for detecting significant fibrosis (≥F2) were not influenced by ALT, the AUC for detecting fibrosis ≥ F2 was 0.862 (0.820–0.903). The cutoff for confirming diagnosis was 9.8 kPa (specificity 0.945, PLR 11.0 and positive predictive value [PPV] 0.972), and the cutoff 5.0 kPa (sensitivity 0.991, NLR 0.04 and negative predictive value [NPV] 0.875) for excluding diagnosis was within the normal range in Asian studies 25,26 . Therefore, we constructed a clinical algorithm of TE performance for recommendation of antivirus treatment to prevent CHB disease progression and development of HCC (Fig.…”

Clinical Application of Transient Elastography in the Diagnosis of Liver Fibrosis: an Expert Panel Review and Opinion

“… 25 Normal LSM values of adult male residents without notable liver disease in Guangdong have been found to vary with age (age < 60 years: 5.2 ± 1.3 kPa; age ≥ 60 years: 5.9 ± 1.8 kPa). 26 The normal reference range in a South Asia population was found to be 3.2–8.5 kPa, and lean or obese people have higher values than those with normal BMIs. 27 The normal reference range in people with no significant liver disease in Hong Kong was found to be 2.8–7.4 kPa.…”