(392) Weight change in adults with postherpetic neuralgia receiving gabapentin enacarbil in a randomized, placebo-controlled trial

Weight-centric treatment of depression and chronic pain

“…In an open-label study, 57% and 23% of patients with seizures on gabapentin gained ≥5% and ≥10% of their baseline weight, respectively [ 19 , 137 ]. In another RCT in patients with postherpetic neuralgia, statistically significant weight gain was reported only in the high dose groups (2400 mg and 3600 mg) with a weight gain of 1.2 kg and 1.8 kg over 14 weeks, respectively (p = 0.02 and p < 0.001) [ 138 ].…”