Weight-centric treatment of depression and chronic pain

Weight-centric treatment of type 2 diabetes mellitus

“…In this review series, we have already discussed the effect of medications for depression and chronic pain on body weight [ 21 ]. We also presented a personalized approach for prescribing medication for these two prevalent diseases.…”

Stress, psychiatric disease, and obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022

“…These may lead to altered eating patterns, altered mood, and social stigma, as well as potential worsening of both obesity and depression. Depression is a predictor of the development of obesity [ 106 ]. Conversely, healthful nutrition, routine physical activity, and attaining a healthy body weight may improve depression [ 95 , 96 ].…”

“…Obesity and depression are linked in part through the effects of nutrition and physical activity [ 97 ]. Management of both obesity and depression optimally involve a comprehensive, patient-centered approach including medical history, physical exam, laboratory evaluation if beneficial, appropriate diagnosis, and psychological support void of bias [ 106 ]. Healthful nutrition and routine physical activity may likewise improve obesity and depressive symptoms.…”

“…Like obesity, medications are often indicated to treat depression for patients who do not respond to non-pharmacologic therapy. However, clinicians and patients should be aware of the potential weight effects of anti-depression therapy, especially in patients with obesity or at risk for obesity [ 100 , 101 , 106 ] (See Table 3 , Table 4 ).…”

The association between previous use of anti‐obesity medication and semaglutide weight loss outcomes

“…Although this medication demonstrated remarkable efficacy, 6 there is significant heterogeneity in weight loss outcomes in patients with overweight or obesity 9 . Several parameters have been shown to be associated with inferior weight loss outcomes including the co‐occurrence of other diseases associated with weight gain (e.g., Cushing disease, 10 T2D 11,12 ), or taking other medications that might promote weight gain 13,14 . However, additional factors that may affect the response to semaglutide are yet to be discovered.…”