3874 H1 and H3, Novel Antifungal Heptaene Antibiotics Produced by Streptomyces sp. HAG 003874.

p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte: Streptomyces griseus subsp.

“…Compounds 1 − 3 appear to be precursors of aminoacetophenone heptaene antibiotics such as levorin , and trichomycin, which are fungicidal compounds known to be produced by Streptomyces species and which have a wide spectrum of therapeutic activities. , These antibiotic compounds could be considered as macrolides esterified at the seventh hydroxyl-substituted carbon (counting from the carbonyl carbon in the side chain). Our HPLC-MS analyses of the crude extract of the S. griseus title strain could not detect this class of macrolide compounds.…”

Amaryllidaceae, Sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids (July 1998 to June 1999)

“…HAG OO3874. 165 The total synthesis of cyclic marine alkaloids halidamine A 407 and halidamine B 408 have been brought about by reacting the deactivated pyridine mesylate 409 with pyridine derivative 410 yielding 411 which was deprotected to give 412, mesylated to yield 413, deoxygenated to afford 414 and cyclised to 415. This compound 415 was converted into 407 by sodium borohydride reduction; 408 was synthesised by the same methodology.…”