Amaryllidaceae, Sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids (July 1998 to June 1999)

Chapter 3 Chemical and Biological Aspects of Narcissus Alkaloids

“…The history of the Amaryllidaceae alkaloids, their structural elucidation, and their biological profiles, as well as their synthesis, have been summarized on several occasions (20,33,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) which, together with the regular publications in the journal Natural Product Reports (34,(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66), represent a valuable source of information.…”

“…An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211). An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211).…”

Ring strain strategy for the control of regioselectivity. Gold-catalyzed anti-Markovnikov cycloisomerization initiated tandem reactions of alkynes

“…However, when NIS is employed as halogenation agent, the vinyl gold intermediate would instead be trapped by NIS to provide vinyl iodide 10-A, which is further 3.6. Gold-catalyzed tandem cycloisomerization/hydrogenation of chiral homopropargyl sulfonamides for the synthesis of enantioenriched pyrrolidines Chiral pyrrolidines are highly useful and valuable frameworks that can be found in a large number of biologically active natural products and pharmaceutical agents [53][54][55][56]. In addition, they can also serve as important organocatalysts [57][58][59][60] and ligands in organic synthesis [61][62][63].…”

Asymmetric Synthesis of Pyrrolidine‐Containing Chemical Scaffolds via Tsuji–Trost Allylation of N‐tert‐Butanesulfinyl Imines

“…[5,6] Furthermore, these compounds have been used as ligands for transition metals, organocatalysts, [7][8][9] and effective chiral controllers in asymmetric synthesis. [10][11][12] It has been observed that there is a significant interest in the stereoselective synthesis of chiral pyrrolidines, using N-tert-butanesulfinyl imines as a chiral auxiliary. In particular, by the addition of Grignard reagents [13] or hydride[14] to γ-chlorinated N-tert-butanesulfinyl imines followed by cyclisation, or via Wacker-type oxidation cyclisation of alkenes with tertbutanesulfinamide nucleophiles [15] or iodocyclisation of homoallylic sulfonamides.…”