368 Assessment of left ventricular systolic dysfunction by tissue Doppler imaging shows evidence of subclinical cardiomyopathy early after anthracycline therapy

Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy

“…Similarly, another observational study showed that changes in LV longitudinal peak systolic strain and LV remodeling were observed early in patients receiving anthracycline chemotherapy (Poterucha et al, 2012). Accordingly, the results of our experimental study (i.e., preclinical study) support the findings of those previous studies (Lotrionte et al, 2007;Poterucha et al, 2012) (i.e., clinical observational study) that cardiotoxicity quite often developed at an early stage of DOX therapy.…”

“…Additionally, cardiotoxicity/cardiomyopathy occurred at an early stage of DOX therapy (by day 28). Intriguingly, one clinical observational study previously revealed that subclinical systolic dysfunction occurs in almost 50% of patients early after anthracycline (DOX is one kind of anthracycline) therapy (Lotrionte et al, 2007). Similarly, another observational study showed that changes in LV longitudinal peak systolic strain and LV remodeling were observed early in patients receiving anthracycline chemotherapy (Poterucha et al, 2012).…”

Appraising cardiotoxicity associated with liposomal doxorubicin by means of tissue Doppler echocardiography end-points

“…On the basis of literature evidence and previous studies from our group [27], we may hypothesize that a significant change in TDI parameters is already established at 12 months of follow-up, precisely with 1.5 cm/s intergroup decrease in systolic velocity (from 11.0 cm/s at baseline to 7.5 cm/s at follow-up in the liposomal doxorubicin arm, and from 11.0 cm/s at baseline to 6.0 cm/s at follow-up in the epirubicin arm), with an intergroup standard deviation of 3.0 cm/s. Aiming at α = 005 and 1 − β = 0.80, we can compute that at least 32 patients should be enrolled per group (total 64).…”

Alterations in the echocardiographic variables of the right ventricle in asymptomatic patients with breast cancer during anthracycline chemotherapy

“…Echocardiography is a non-invasive, cost-effective and widely available cardiac imaging tool that is well positioned to serve as the primary screening modality for chemotherapy-induced cardiotoxicity, and tissue Doppler echocardiography (TDE) indices have been shown to be sensitive for detecting local damage to ventricles before the heart is globally affected 12 13…”