Appraising cardiotoxicity associated with liposomal doxorubicin by means of tissue Doppler echocardiography end-points

Advances in Precision Medicine Oncology

“…It is interesting to note that the accumulation of Tregs within the tumors upon CTLA-4 blockade may be induced by a feedback loop triggered by a successful cytotoxic T cell response [97]. This may account for the positive correlation between the intra-tumoral levels of Tregs and patient long-term survival as reported by some studies involving solid tumors [98,99]. These observations nonetheless suggest that Tregs dynamics under CTLA-4 treatment, in the TME and possibly in the periphery, should be accounted for when monitoring for treatment effects.…”

“…Indirectly active in chromatin remodelling complexes by activating vitamin D receptors. DZR is often known to provide up-regulation of the ERK and Akt pathways to guard against cardiomyopathy [93][94][95][96] but DZR is not approved for routine use in patients with metastatic cancer and other forms of cancer, as stated by the American Clinical Oncology Society [97,98]. DOX was analysed in association with DZR for 10 years in women with breast cancer [99].…”

“…For instance, the P-gp modulating effect of asiatic acid, ginsenoside, isoquinoline alkaloids (e.g. cepharantine, tetrandine) resulted from their blockade of MAPK/ERK1/2 or PI3K/Akt pathways in MDR cancer cells [86,[98][99][100][101]. Another isoquinoline alkaloid berberine inhibited P-gp expression and enhanced doxorubicin-mediated toxicity in MCF-7 cells through down-regulation of AMPK-HIF1α signaling cascade [102].…”

State of the art paper Prognostic role of troponin and natriuretic peptides as biomarkers for deterioration of left ventricular ejection fraction after chemotherapy

“…Liposomal anthracyclines have the potential for more selective uptake by cancer cells and reduced cardiac toxicity [15]. A positive role in heart failure protection has also been reported in dexrazoxane treatment.…”