A Clinical Study of Platelet-Rich Fibrin Combined With Autologous High-Density Fat Transplantation in Augmentation Rhinoplasty

Abstract

Objective: This study was designed to analyze the clinical effect of autologous fat-granule transplantation in augmentation rhinoplasty and explore methods to improve the fat retention rate. Methods: A total of 70 enrolled patients were randomly divided into 2 groups: the platelet-rich fibrin (PRF) combined with high-density fat transplantation group (combined group) and the conventional fat-granule transplantation group (control group; n = 35 in each group). In the combined group, an appropriate amount of autologous fat was extracted and centrifuged, and the lower layer of high-density fat was taken and mixed with PRF isolated from whole blood for autotransplantation. In the control group, only fat was extracted and centrifuged for transplantation. The patients were followed up with for more than one year to observe the short- and long-term effects, complications, safety, and patient satisfaction. Results: Six months after the operation, the nasal shape was stable, the contour was higher and more stereoscopic than before, the average increase of nasal height was 3.0 mm in the combined group and 2.0 mm in the control group. No complications, such as fat embolism, infection, or necrosis occurred during the 1-year follow-up. The satisfaction rate between the 2 groups has statistical significance ( P < .05). Conclusion: Overall, PRF combined with autologous high-density fat transplantation is simple to perform, has a significantly increased fat-retention rate than the control group, and has stable long-term effects without obvious adverse reactions. A sufficient amount of fat and PRF transplantation can achieve a good orthopedic effect. Thus, this method can be widely used in clinical augmentation rhinoplasty.

The Application and Efficacy Evaluation of Autologous Fat Transplantation in Antiaging of the Face: Systematic Review and Meta-Analysis

“…Long-term studies were conducted during the operation. It may be related to the preparation of SVF, sometimes requiring a large amount of fat injection and longer liposuction time [ 15 ].…”

The Role of Autologous Fat Grafting in Rhinoplasty

“…59,64 Some supplements such as platelet-rich fibrin, as introduced by Kovacevic et al, can potentially increase the retention of the fat graft and its regenerative effect on the surrounding soft tissue. 61,65,67,75 These observations were also evident in vitro studies. 45,68,69 Moreover, it can prevent the shrink-wrap phenomenon and camouflage irregularities, particularly in thin-skinned patients.…”

“…Moreover, this regenerative effect can promote the retention of cartilage grafts 60,65 . Some supplements such as platelet-rich fibrin (PRF), as introduced by Kovacevic et al, can potentially increase the retention of the fat graft and its regenerative effect on the surrounding soft tissue 62,66,68 . These observations were also evident in vitro studies 45,69,70 .…”

Exosomes based advancements for application in medical aesthetics

“…However, there are still many challenges in aesthetics, for example, it is difficult to control the dose of anti-oxidant injection ( Shekhter et al, 2019 ; Gazitaeva et al, 2021 ). In clinical practice, fat transplantation is often used in medical aesthetics, but it may lead abnormal local contour shape and to increase foreign body sensation ( Yan et al, 2021 ). Subsequently, stem cell therapy was gradually applied to regenerative medicine due to its pluripotency, self-renewal and ability to promote the secretion of regenerative cytokines ( Johari et al, 2019 ; Li W. et al, 2022 ), but stem cell therapy may induce the risk of tumorigenesis and malformation ( Trounson and McDonald, 2015 ).…”