Exosomes based advancements for application in medical aesthetics

Abstract

Beauty is an eternal pursuit of all people. Wound repair, anti-aging, inhibiting hyperpigmentation and hair loss are the main demands for medical aesthetics. At present, the repair and remodeling of human body shape and function in medical aesthetics are often achieved by injection of antioxidants, hyaluronic acid and botulinum toxin, stem cell therapy. However, there are some challenges, such as difficulty controlling the injection dose, abnormal local contour, increased foreign body sensation, and the risk of tumor occurrence and deformity induced by stem cell therapy. Exosomes are tiny vesicles secreted by cells, which are rich in proteins, nucleic acids and other bioactive molecules. They have the characteristics of low immunogenicity and strong tissue penetration, making them ideal for applications in medical aesthetics. However, their low yield, strong heterogeneity, and long-term preservation still hinder their application in medical aesthetics. In this review, we summarize the mechanism of action, administration methods, engineered production and preservation technologies for exosomes in medical aesthetics in recent years to further promote their research and industrialization in the field of medical aesthetics.

The Innovative and Evolving Landscape of Topical Exosome and Peptide Therapies: A Systematic Review of the Available Literature

“…Exosomes also may mediate the inflammatory response to skin damage, improving wound healing, while promoting angiogenesis, tissue remodeling, and extracellular matrix deposition. 33 Additionally, these cytokines play an integral role in many dermatologic processes, leading to potential for exosome use in treatment of dermatologic pathologies such as dermatitis, psoriasis, and wound healing, among others.…”

Skin boosters: Definitions and varied classifications

“…Exosome despite being plentiful in nature, present significant challenge in extraction and stabilization owing to their diminutive size and sensitivity to fluctuations in temperature, pressure and pH. Although numerous sources and techniques for isolation and stabilization have been suggested, there remains a lack of a universally accepted method for their isolation and purification 51 . Exosomes are small extracellular vesicles secreted by cell types and are a main component of cellular communication and molecule transportation.…”

“…Applying exosomes directly after skin rejuvenation treatments like fractional laser, microneedling, radiofrequency micro‐needling, and microdermabrasion aids in the healing process. This approach helps to mitigate symptoms associated with these procedures, including erythema, edema, and discomfort 51 . Exosomes have been demonstrated to expedite the transition from inflammatory wound repair to the remodelling phase by diminishing the expression of inflammatory factors.…”

“…Notably, a number of products advertised as “growth factor” are actually secretome products, which consists of exosomes. Recent scientific advancements have shed light on the critical role played by extracellular vesicles, particularly exosomes, in the intricate cellular communication processes involved in various biological functions, including wound healing and skin repair 51,60 …”

“…Dermal including wound healing and skin repair. 51,60 Secretomes can be derived from various sources, including bone marrow, adipose tissue, neonatal tissue, skin tissue, and peripheral blood. They have been shown to enhance the migration and proliferation of various dermal cells, including fibroblasts, endothelial cells and keratinocytes, and the epidermis.…”