Association between the triglyceride-glucose index and abdominal aortic calcification in adults: A cross-sectional study

Chen, Yuxiong; Chang, Zhen’ge; Zhao, Yakun; Liu, Yanbo; Jia, Fu; Zhang, Yongqiao; Liu, Yijie; Fan, Zhongjie

doi:10.1016/j.numecd.2021.04.010

Cited by 21 publications

(12 citation statements)

References 51 publications

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“…Additionally, it has been also revealed that TyG index is significantly associated with vascular calcification ( 33 , 34 ) and arterial stiffness ( 35 ), both of which are indicators of atherosclerosis and important for early prediction of cardiovascular disease. Moreover, former studies have also demonstrated that individuals with a higher level of TyG index were often exhibited to be more likely to combine with various traditional risk factors for cardiovascular disease including diabetes ( 10 ), prediabetes ( 11 ), hypertension ( 12 , 36 ), renal dysfunction ( 37 ), and hyperuricemia ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Zhao

Liu²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundTriglyceride-glucose (TyG) index, a novel surrogate marker of insulin resistance, has been demonstrated to be significantly associated with cardiovascular disease. It remains indistinct regarding the association between TyG index and non-culprit coronary plaque characteristics in patients following acute coronary syndrome (ACS).MethodsThe present study retrospectively recruited patients who were diagnosed with ACS and underwent non-culprit optical coherence tomography (OCT) examination. The study population was divided into 2 groups based on the median of TyG index, which was calculated as Ln [fasting triglyceride (TG) (mg/dL) × fasting blood glucose (FBG) (mg/dL)/2]. The non-culprit plaque characteristics were determined by interpreting OCT images in accordance with the standard of previous consensus.Results110 patients (54.8 ± 12.1 years, 24.5% female) with 284 non-culprit plaques were included in the current analysis. TyG index was closely associated with high-risk plaque characteristics. Elevated TyG index was consistent to be an independent indicator for thin-cap fibroatheroma (TCFA) [odds ratio (OR) for per 1-unit increase 4.940, 95% confidence interval (CI) 1.652–14.767, P = 0.004; OR for taking lower median as reference 2.747, 95% CI 1.234–7.994, P = 0.011] and ruptured plaque (OR for per 1–unit increase 7.065, 95% CI 1.910–26.133, P = 0.003; OR for taking lower median as reference 4.407, 95% CI 1.208–16.047, P = 0.025) in fully adjusted model. The predictive value of TyG index for TCFA and ruptured plaque was moderate–to–high, with the area under the receiver operating characteristic curve (AUC) of 0.754 and 0.699 respectively. The addition of TyG index into a baseline model exhibited an incremental effect on the predictive value for TCFA, manifested as an increased AUC (0.681, 95% CI 0.570–0.793 vs. 0.782, 95% CI 0.688–0.877, P = 0.042), and significant continuous net reclassification improvement (0.346, 95% CI 0.235–0.458, P < 0.001) and integrated discrimination improvement (0.221, 95% CI 0.017–0.425, P = 0.034). TyG index failed to play an incremental effect on predicting ruptured plaque.ConclusionTyG index, which is simply calculated from fasting TG and FBG, can be served as an important and independent risk predictor for high-risk non-culprit coronary plaques in patients following ACS.

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Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Zhao

Liu²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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“…Potential covariates may confound the association between BLL and AAC were summarized in our multivariable-adjusted models based on previous studies (26,(30)(31)(32). Continuous variables in our study included age, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine, serum cotinine, hemoglobin A1c, serum uric acid, serum calcium, serum phosphorus, total cholesterol, and total 25hydroxyvitamin D. Categorical variables included gender, race, education level, body mass index (BMI), hypertension, and diabetes.…”

Section: Covariatesmentioning

confidence: 99%

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Zheng

et al. 2021

Front. Cardiovasc. Med.

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Aims: This study aimed to evaluate the association between blood lead level (BLL) and abdominal aortic calcification (AAC) in US adults aged ≥40 years.Methods: We obtained data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES). Participants missing the data of BLL and AAC scores were excluded. BLL was measured using inductively coupled plasma mass spectrometry directly. AAC scores were quantified by Kauppila score system, and severe AAC was defined as AAC score >6. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between BLL with AAC score and severe AAC.Results: A total of 1,530 participants were included with the mean BLL of 1.45 ± 1.31 ng/dl and mean AAC score of 1.40 ± 3.13. The prevalence of severe AAC was 7.98% overall, and participants in higher BLL quartile showed higher prevalence of severe AAC (Quartile 1: 3.55%, Quartile 2: 7.28%, Quartile 3: 9.88%, Quartile 4: 12.58%, P < 0.0001). BLL was positively associated with higher AAC score (β = 0.15, 95% CI: 0.02, 0.27, P = 0.021) and increased risk of severe AAC (OR = 1.11; 95% CI: 1.00–1.22; P = 0.047). Subgroup analysis and interaction test indicated that the association between BLL and AAC was similar in different population settings.Conclusions: Higher BLL was associated with higher AAC score and increased risk of severe AAC. Lead burden should be considered for people with AAC in clinical settings.

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“…The TYG index has been reported to be associated with stroke, carotid atherosclerosis, microvascular and macrovascular injury, and coronary artery disease [7][8][9]. Studies have been conducted to link abdominal aortic calci cation scores with TgY in adults [10,11]. However, no study has investigated the association between the TYG index and the risk of abdominal aortic calci cation in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Relationship between triglyceride glucose index and severe abdominal aortic calcification in the elderly

Pan

Guo

et al. 2023

Preprint

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Background The association between triglyceride glucose (TYG) index and depression is unclear. We conducted this analysis to explore whether higher TYG index is associated with a higher odd of depression. Aims The objective was to investigate the relationship between TYG and abdominal aortic calcification (AAC) in people over 60 years old. Methods The National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between TYG index and the Kauppila AAC-24 score. Results A total of 1,408 people took part in our study. Participants with higher TYG quartiles had higher AAC scores. SAAC was defined as a Kauppila score > 6, and the prevalence of SAAC was 17.0%. After adjusting for relevant covariates, the multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CI) for participants in the third and fourth quartiles were 1.970 (1.232–3.150, P = 0.005) and 2.261 (1.404–3.644, P < 0.001). Subgroup analyses indicated that the positive association between TYG and SAAC persisted across population subgroups. Conclusion Triglyceride glucose index was negatively correlated with SAAC in the elderly.

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Association between the triglyceride-glucose index and abdominal aortic calcification in adults: A cross-sectional study

Cited by 21 publications

References 51 publications

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Relationship between triglyceride glucose index and severe abdominal aortic calcification in the elderly

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