Phthalates exposure during pregnancy a study in a Mexican cohort

Bustamante-Montes, Lilia Patricia; Borja-Aburto, Víctor Hugo; Hernández‐Valero, María A.; García-Fábila, María Magdalena; Borja-Bustamante, Patricia; González-Álvarez, Rafael; Acosta-Gordillo, Germán Antonio

doi:10.1016/j.toxrep.2021.05.006

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…According to Li et al [22], phthalate metabolite concentrations throughout the pregnancy were U-shaped; the highest concentrations of phthalates were detected in the 1st and third trimesters. A similar trend to our study was observed in the study of Bustamante-Montes et al [23]; they noticed higher concentrations of MBP, MEP, and MEHP during the third trimester compared to the first trimester in the cohort of pregnant women. The possible explanation of higher exposure to certain phthalates during the third trimester might be a difference in caloric intake throughout the pregnancy.…”

Section: Biomonitoring Of Maternal Phthalate Metabolitessupporting

confidence: 92%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.

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Section: Biomonitoring Of Maternal Phthalate Metabolitessupporting

confidence: 92%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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“…2019 ; James-Todd et al. 2017 ), by neighborhood ( Bustamante-Montes et al. 2021 ), and by education ( Zhu et al.…”

Section: Discussionmentioning

confidence: 99%

“…Early life exposures to NMPs and plastics reflect numerous commercial and social determinants of health and are likely linked to health inequalities. Global inequalities in pregnant women's body burden of plastic chemicals has, for example, been reported by income (Wenzel et al 2018), by race/ethnic group (Bloom et al 2019;James-Todd et al 2017), by neighborhood (Bustamante-Montes et al 2021), and by education (Zhu et al 2016), among other socioeconomic factors. Some of this variation may reflect differences in proximity to pollution sources, dietary behaviors, occupational exposures, use of personal care products (Helm et al 2018;Zota and Shamasunder 2017), and intersections of these factors.…”

Section: Global Context Policy and Health Inequalitiesmentioning

confidence: 99%

A Children’s Health Perspective on Nano- and Microplastics

Sripada

Wierzbicka

Abass

et al. 2022

Environ Health Perspect

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Background: Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- and microplastics (NMPs) remain largely uninvestigated or unknown. Although plastic chemicals are a well-established research topic, the impacts of plastic particles are unexplored, especially with regard to early life exposures. Objectives: This commentary aims to summarize the knowns and unknowns around child- and pregnancy-relevant exposures to NMPs via inhalation, placental transfer, ingestion and breastmilk, and dermal absorption. Methods: A comprehensive literature search to map the state of the science on NMPs found 37 primary research articles on the health relevance of NMPs during early life and revealed major knowledge gaps in the field. We discuss opportunities and challenges for quantifying child-specific exposures (e.g., NMPs in breastmilk or infant formula) and health effects, in light of global inequalities in baby bottle use, consumption of packaged foods, air pollution, hazardous plastic disposal, and regulatory safeguards. We also summarize research needs for linking child health and NMP exposures and address the unknowns in the context of public health action. Discussion: Few studies have addressed child-specific sources of exposure, and exposure estimates currently rely on generic assumptions rather than empirical measurements. Furthermore, toxicological research on NMPs has not specifically focused on child health, yet children’s immature defense mechanisms make them particularly vulnerable. Apart from few studies investigating the placental transfer of NMPs, the physicochemical properties (e.g., polymer, size, shape, charge) driving the absorption, biodistribution, and elimination in early life have yet to be benchmarked. Accordingly, the evidence base regarding the potential health impacts of NMPs in early life remains sparse. Based on the evidence to date, we provide recommendations to fill research gaps, stimulate policymakers and industry to address the safety of NMPs, and point to opportunities for families to reduce early life exposures to plastic. https://doi.org/10.1289/EHP9086

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Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones

Yang

et al. 2022

Environ Sci Pollut Res

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Phthalates exposure during pregnancy a study in a Mexican cohort

Abstract: Graphical abstract

Cited by 5 publications

References 40 publications

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

A Children’s Health Perspective on Nano- and Microplastics

Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones

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