“…We also observe trends in transcriptional expression indices (TEI) for pancreatic β-cell maturation that include PAX4 , NKX6-1 , NKX2-2 , KAT2B , ONECUT , HNF1A , GCK , MAFA and PDX1 . 25 Furthermore, we observe strong correspondence with NGN3 + progenitor and pancreatic precursor pathways with transcriptional expression of FGF10, PTF1A, NKX6-1, NKX2-2, KAT2B, PDX1, PAX4 and ONECUT3 indicative of endocrine progenitor specification and β-cell development. 26 Differential expression in the IGF pathway genes such as FGA, VWA1, TGOLN2, ALB, CTSG, IL6, APOB , and FUCA2 indicate regulatory roles in IGF signalling essential for β-cell proliferation and survival.…”