Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents

Gvazava, I. G.; Karimova, M. V.; Vasiliev, A. V.; Vorotelyak, E. A.

doi:10.32607/actanaturae.11751

Cited by 4 publications

(2 citation statements)

References 155 publications

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“…Chemically induced diabetes rodent models are primarily used due to easily induced diabetes, a short induction period, and cost-effectiveness ( Furman, 2021 ). Relevant data on such rodent models are summarized in reviews by Gvazava et al ( Gvazava et al, 2018 ; 2022 ). However, traditionally, models based on pancreatic duct ligation (PDL) and partial pancreatectomy were used to study β-cell regeneration, demonstrating the fundamental possibility of pancreatic regeneration.…”

Section: Regeneration Of the Pancreasmentioning

confidence: 99%

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Chernysheva,

Ruchko,

Karimova

et al. 2024

Front. Cell Dev. Biol.

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Pancreatic regeneration is a complex process observed in both normal and pathological conditions. The aim of this review is to provide a comprehensive understanding of the emergence of a functionally active population of insulin-secreting β-cells in the adult pancreas. The renewal of β-cells is governed by a multifaceted interaction between cellular sources of genetic and epigenetic factors. Understanding the development and heterogeneity of β-cell populations is crucial for functional β-cell regeneration. The functional mass of pancreatic β-cells increases in situations such as pregnancy and obesity. However, the specific markers of mature β-cell populations and postnatal pancreatic progenitors capable of increasing self-reproduction in these conditions remain to be elucidated. The capacity to regenerate the β-cell population through various pathways, including the proliferation of pre-existing β-cells, β-cell neogenesis, differentiation of β-cells from a population of progenitor cells, and transdifferentiation of non-β-cells into β-cells, reveals crucial molecular mechanisms for identifying cellular sources and inducers of functional cell renewal. This provides an opportunity to identify specific cellular sources and mechanisms of regeneration, which could have clinical applications in treating various pathologies, including in vitro cell-based technologies, and deepen our understanding of regeneration in different physiological conditions.

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Section: Regeneration Of the Pancreasmentioning

confidence: 99%

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Chernysheva,

Ruchko,

Karimova

et al. 2024

Front. Cell Dev. Biol.

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“… 1 Type 2 Diabetes Mellitus (T2DM), in particular, accounts for 90% of all diabetes cases. 2 Annually, over a million people succumb to diabetes, ranking it as the ninth leading cause of death. 3 The cost of diabetes care surpasses per capita healthcare expenditure by a minimum of 3.2 times, escalating to 9.4 times when complications arise.…”

Section: Introductionmentioning

confidence: 99%

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Si,

Xiao,

Zheng

et al. 2024

DMSO

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Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research

Gorskaya,

Vasilev

2024

Sensornye sistemy

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Olfactory impairment (decreased acuity, impaired adequate identification of odorants) reduces the quality of life of patients and can be a symptom of a wide range of pathologies of the organism, in particular neurodegenerative processes in the brain. Quantitative measurement of olfactory acuity is necessary for diagnostics of olfactory dysfunctions, monitoring the dynamics of olfaction after pharmacological or surgical treatment. The searching for optimal methods of analyzing olfactory thresholds on animal models of human diseases accompanied by anosmia and comparing them with those in humans seems to be especially urgent problem at the moment. This is necessary for the selection of a valid animal model for the evaluation of new drugs and development the therapy for a wide range of pathologies. The review analyzes publications devoted to the study of diseases accompanied by anosmia or hyposmia, their zootropic models, and methods of olfactory function assessment. Models for COVID19, Alzheimer’s disease, Parkinson’s disease, diabetes types (1 and 2 type), Kalman syndrome, and Bardet-Biedl syndrome, for which olfactory dysfunction and/or defects of olfactory system are present, were analyzed. The review notes the paucity of data on the measurement of olfactory thresholds in model animals.

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Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents

Cited by 4 publications

References 155 publications

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research

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