Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice

Lu, Rufeng; Wu, Yi-Long; Guo, Honggang; Zhang, Zhuoyi; He, Yongchun

doi:10.1177/15593258211011335

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2022

2024

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Cited by 2 publications

References 18 publications

(27 reference statements)

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Phytochemicals as Modulators of Toll-Like Receptors: An Immunopharmacological Perspective

Chakraborty,

Chatterjee,

Chakraborty

et al. 2024

Medicinal Plants and Antimicrobial Therapies

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Phytochemicals as Modulators of Toll-Like Receptors: An Immunopharmacological Perspective

Chakraborty,

Chatterjee,

Chakraborty

et al. 2024

Medicinal Plants and Antimicrobial Therapies

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Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication

Genovese

Garozzo

D’Angeli

et al. 2022

Cells

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Background: Breast cancer (BC) is the leading cause of death worldwide. The severity of BC strictly depends on the molecular subtype. The less aggressive hormone-positive subtype is treated with adjuvant endocrine therapy (AET), which causes both physical and psychological side effects. This condition strongly impacts the adherence and persistence of AET among oncologic patients. Moreover, viral infections also constitute a serious problem for public health. Despite their efficacy, antiviral agents present several therapeutic limits. Accordingly, in the present work, we investigated the antitumor and antiviral activities of Orobanche crenata Forssk. (O. crenata), a parasitic plant, endemic to the Mediterranean basin, traditionally known for its beneficial properties for human health. Methods: The MTT assay was carried out to evaluate the cytotoxic effect of O. crenata leaf extract (OCLE) on human breast cancer cells (MCF-7 and MDA-MB-231) and the primary HFF-1 cell line. The lactic dehydrogenase (LDH) assay was performed on MCF-7 cells to analyze necrotic cell death. The antioxidant effect of OCLE was evaluated by intracellular determination of the reactive oxygen species and thiol groups, by DPPH and ABTS assays. The antiviral activity of OCLE was determined against Poliovirus 1, Echovirus 9, Human respiratory syncytial virus, Adenovirus type 2 and type 5, Coxsackievirus B1 (CoxB1) and B3 (CoxB3), Herpes simplex type 1 (HSV-1) and type 2 (HSV-2), and β-Coronavirus by the plaque reduction assay. Results: The extract, after 24 h of incubation, did not affect MDA-MB-231 and HFF-1 cell viability. However, at the same time point, it showed a dose-dependent inhibitory effect on MCF-7 cells, with an increase in LDH release. OCLE exhibited free radical scavenging activity and significantly increased non-protein thiol levels in MCF-7 cells. OCLE effectively inhibited HSV-1, HSV-2, CoxB1, and CoxB3 replication. Conclusions: The overall results showed an interesting inhibitory effect of OCLE on both MCF-7 cell survival and viral replication.

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Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice

Cited by 2 publications

References 18 publications

Phytochemicals as Modulators of Toll-Like Receptors: An Immunopharmacological Perspective

Phytochemicals as Modulators of Toll-Like Receptors: An Immunopharmacological Perspective

Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication

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