Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials

Alimohammadi, Mona; Rahimi, Alireza; Faramarzi, Fatemeh; Golpour, Monireh; Jafari-Shakib, Reza; Alizadeh‐Navaei, Reza; Rafiei, Alireza

doi:10.1007/s10787-021-00817-8

Cited by 20 publications

(10 citation statements)

References 66 publications

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“…The study illustrated that CoQ10 supplementation can directly or indirectly through increasing SOD and CAT levels significantly, decreasing the levels of MDA considerably and may thereby affect OS and subsequent pathophysiological events. However, significant associations were not observed between this supplement and TAC, GPx activity, which differs from some previous studies ( Alimohammadi et al, 2012 ; Akbari et al, 2020 ; Sangsefidi et al, 2020 ) and may be attributed to the generalizability of the included population and the diversity of disease types. Additionally, we also conducted subgroup meta-analysis comparing studies with different dosages, duration, and types of diseases.…”

Section: Discussioncontrasting

confidence: 99%

“…Nevertheless, the results obtained were contradictory. Additionally, weak search strategy, not registered in advance, monotonous types of diseases, and lack of assessing CoQ10 impact on comprehensive OS markers such as TAC are limitations in previous systematic reviews and meta-analysis ( Jorat et al, 2019 ; Akbari et al, 2020 ; Alimohammadi et al, 2021 ). Hence, it gave us the opportunity to update the relevant evidence and conducted this study.…”

Section: Introductionmentioning

confidence: 99%

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Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population

et al. 2022

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Background: Oxidative stress (OS) is associated with ferroptosis. Coenzyme Q10 (CoQ10), as an adjuvant treatment, has shown to be beneficial against OS. However, the efficacy of CoQ10 as a therapeutic agent against OS has not been promptly updated and systematically investigated.Methods: A systematic literature search was performed using the Medline, EMBASE, Web of science, Cochrane Central Register of Controlled Trials, CNKI, CBM, Science direct and clinical trial. gov to identify randomized clinical trials evaluating the efficacy of CoQ10 supplementation on OS parameters. Standard mean differences and 95% confidence intervals were calculated for net changes in OS parameters using a random-effects model.Results: Twenty-one randomized clinical studies met the eligibility criteria to be included in the meta-analysis. Overall, CoQ10 supplementation increased the levels of antioxidant enzymes [including superoxide dismutase (SOD) (SMD = 0.63; 95% CI: 0.38 to 0.88; p < 0.001), catalase (CAT) (SMD = 0.44; 95% CI:0.16 to 0.72; p = 0.002)] significantly and the levels of malondialdehyde (MDA) (SMD = -0.68; 95% CI: 0.93 to -0.43; p < 0.001) was decreased considerably. However, significant associations were not observed between this supplement and total antioxidant capacity (TAC), glutathione peroxidase (GPx) activity.Conclusion: CoQ10 can improve OS as indicated by statistical significance in CAT and MDA concentrations, as well as SOD activity. Future studies focusing on long-term results and specific valuation of OS parameters are required to confirm the efficacy of CoQ10 on OS. We also believe that with the further research on ferroptosis, CoQ10 will gain more attention.Systematic Review Registration: [https://inplasy.com/], identifier [INPLASY2021120123].

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population

et al. 2022

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“…For example, Jolliet et al [ 21 ] indicated that increased COQ10 levels in plasma of patients with breast cancer were associated with good prognosis. However, supplementation with CoQ10 reduced some of the important markers of inflammation and MMPs in patients with breast cancer [ 22 ]. Meanwhile, CoQ10 showed a tendency to be associated with improved prognosis of lung cancer [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

COQ10B Knockdown Modulates Cell Proliferation, Invasion, Migration, and Apoptosis in Esophageal Squamous Cell Carcinoma

Liu

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Esophageal squamous-cell carcinoma (ESCC) is an aggressive malignant tumor, accounting for more than 90% of esophageal cancers. However, treatments such as surgical resection, radiotherapy, and chemotherapy are unable to achieve ideal clinical outcomes. The purpose of this study was to explore the effects of COQ10B on proliferation, apoptosis, migration, and invasion of esophageal squamous-cell carcinoma (ESCC) cells. Methods. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of COQ10B in ESCC and normal tissues and in ESCC cell lines (KYSE-15 and TE-1). MTT assay and flow cytometry were applied to investigate the effects of COQ10B shRNA lentivirus (LV-shCOQ10B) on ESCC cell proliferation and apoptosis, respectively. The effect of COQ10B silencing on ESCC cell migration and invasion was determined by wound healing assay and transwell invasion assay, respectively. Results. The expression of COQ10B mRNA in ESCC tissues was higher than that in surrounding tissues. The decreased COQ10B level in KYSE-15 and TE-1 cells by LV-shCOQ10B could inhibit cell proliferation, promote cell apoptosis, and reduce the ability of invasion and migration (all P < 0.05 ). Conclusion. COQ10B was highly expressed in human ESCC tissues. COQ10B silencing contributed to the inhibition of proliferation, invasion, and migration of ESCC cells and the promotion of cell apoptosis, suggesting COQ10B may be a potential molecular target for the diagnosis and treatment of ESCC.

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“…Prior systematic reviews of randomized clinical trials (RCTs) have focused on the effects of CoQ10 supplementation on oxidative stress status, but there was less study extended to the general population [ 22 , 23 , 24 , 25 , 26 ]. The number of studies included for the same oxidative stress biomarkers was inconsistent, although the search deadlines were very close [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials

et al. 2022

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Evidence shows that exogenous CoQ10 supplementation may potentially attenuate oxidative stress status. However, its effective dose and evidence certainty require further evaluation in the general population via more updated randomized controlled trials (RCTs). Databases (PubMed, Embase and Cochrane Library) were searched up to 30 March 2022. Evidence certainty was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Thirty-four RCTs containing 2012 participants were included in this review. Pooled effects of significant increase in total antioxidant capacity (TAC) (standardized mean difference: 1.83, 95%CI: [1.07, 2.59], p < 0.001) and significant reduction in malondialdehyde (MDA) concentrations (−0.77, [−1.06, −0.47], p < 0.001) were shown after CoQ10 supplementation compared to placebo. However, we could not determine that there was a significant increase in circulating superoxide dismutase (SOD) levels yet (0.47, [0.00, 0.94], p = 0.05). Subgroup analyses implied that CoQ10 supplementation was more beneficial to people with coronary artery disease or type 2 diabetes. Additionally, taking 100–150 mg/day CoQ10 supplement had better benefits for the levels of TAC, MDA and SOD (all p < 0.01). These results to a statistically significant extent lent support to the efficacy and optimal dose of CoQ10 supplementation on attenuating oxidative stress status in adults.

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Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials

Cited by 20 publications

References 66 publications

Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population

Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population

COQ10B Knockdown Modulates Cell Proliferation, Invasion, Migration, and Apoptosis in Esophageal Squamous Cell Carcinoma

Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials

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