Multiple stage IV colorectal cancers in a patient who received multidisciplinary treatment, including chemotherapy and Japanese Kampo medicine: A case report

Aomatsu, Naoki; Maeda, Kiyoshi; Uchima, Yasutake; Matsutani, Shinji; Tsujio, Gen; Miyamoto, Hironari; Okada, Takuma; Kurihara, Shigeaki; Nishii, Takafumi; Tachimori, Akiko; Ikeda, Katsumi; Takeuchi, Kazuhiro

doi:10.1016/j.npep.2021.102160

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…Table 4 presents the list of clinical studies and Table 5 presents the list of case reports of NYT according to the search strategy. Five randomized clinical trials (RCT) [59][60][61][62][63], four observational studies [64][65][66][67], and 12 case reports were searched [68][69][70][71][72][73][74][75][76][77][78][79][80]. Herein, we summarize the findings of clinical studies on NYT.…”

Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

“…In both cases, anorexia improved after the administration of NYT [63, 64]. Aomatsu et al reported the supportive role of NYT on postoperative weakness or during anticancer treatment in colon cancer [65, 66].…”

Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

“…the supportive role of NYT on postoperative weakness or during anticancer treatment in colon cancer [65,66].…”

Section: [72]mentioning

confidence: 99%

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Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Takayama,

Michihara,

Kimura

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe source of ninjin'yoeito (NYT) is considered the ‘Formulary of Bureau of Taiping People's Welfare Pharmacy’, written around 1241–52 AD. NYT is used to treat patients with chronic fatigue, malaise with qi deficiency, and exhaustion of all five parenchymatous viscera with difficulty in recovering.Key FindingsNYT formula consists of 12 crude drugs. NYT extract for medical use is covered by the National Health Insurance system of Japan for convalescence after recovery from diseases, fatigue and malaise, anorexia, perspiration during sleep, cold limbs, and anemia. Studies have shown clinical effects of NYT: treatment of anemia, cancer treatment support, frailty, cognitive dysfunction, apathy, fatigue/malaise, anorexia, and lung diseases. Preclinical studies support clinical studies; activating ghrelin‐neuropeptide Y pathway‐mediated appetite‐enhancing effects, inhibiting muscle volume loss through the Akt/mTOR pathway‐mediated hyperphosphorylation of 4E‐BP1 and FoxO1‐mediated Atrogin‐1, suppressing the hypothalamic–pituitary–adrenal axis by downregulating the sympathetic‐adrenal‐medullary axis and GABA neurons for improving sociability, promoting recovery from skeletal muscle atrophy through the activation of PGC‐1α, hematopoiesis‐promoting effects, and increasing the number of immune cells in immunocompromised models. The incidence of adverse events of NYT was reported as 3.09 or 2.03%. The most significant adverse effects of NYT are gastrointestinal disorders.ConclusionRecently, NYT has been widely used to treat several symptoms and conditions under the National Health Insurance System of Japan. Clinical studies showed the efficacy of NYT to treat anemia, frailty, cognitive dysfunction, anorexia, apathy, and fatigue/malaise, as well as for long‐term cancer treatment support. The pharmacological mechanisms supporting its effects are also being reported.

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Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

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Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Takayama,

Michihara,

Kimura

et al. 2023

Traditional & Kampo Medicine

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show abstract

“…NYT is composed of 12 herbal plants that are used to promote recovery from illness and improve symptoms such as general fatigue, anemia, anorexia, cough, cancer cachexia, and the side effects of anticancer therapies (Amitani et al, 2015;Aomatsu et al, 2021;Aomatsu et al, 2020;Miyano et al, 2018). These herbal plants include Ginseng, Japanese angelica root, Rehmannia root, Atractylodes rhizome, Poria sclerotium, Peony Root, Citrus unshiu peel, Polygala root, Astragalus root, Cinnamon bark, Schisandra fruit, and Glycyrrhiza (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Ninjin'yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit

Aomatsu¹,

Shigemitsu²,

Nakagawa³

et al. 2021

Neuropeptides

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“…It supports the treatment of various diseases by enhancing patients’ mental health ( Amitani, 2015 ; Kiyomi et al, 2021 ). It is characterized by the inclusion of Ginseng and Astragali Radix ( Aomatsu et al, 2021 ; Miyazaki et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish

et al. 2023

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Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy decline, a comparison between their effects on neuropsychiatric symptoms like anxiety and sociability and the strength of their effects has not been conducted. Therefore, this study compared the effects of Ninjinyoeito, Hochuekkito, and Juzentaihoto on psychiatric symptoms using neuropeptide Y knockout (NPY-KO) zebrafish, a suitable animal model for anxiety and low sociability. Neuropeptide Y knockout zebrafish were fed a Ninjinyoeito, Hochuekkito, or Juzentaihoto-supplemented diet for 4 days. Then, sociability was analyzed using a three-Chambers test and anxiety-like behavior was evaluated using the cold stress and novel tank tests. The results showed that Ninjinyoeito treatment improved the low sociability of neuropeptide Y knockout, while Hochuekkito and Juzentaihoto did not. Neuropeptide Y knockout exhibited anxiety-like behaviors, such as freezing and swimming in the wall area under cold stress, but Ninjinyoeito treatment improved these behaviors. However, these anxiety-like behaviors were not improved by Hochuekkito and Juzentaihoto. Ninjinyoeito treatment also improved anxiety-like behaviors of neuropeptide Y knockout in the novel tank test. However, no improvement was shown in the Hochuekkito and Juzentaihoto groups. This trend was also confirmed in the low water stress test using wild-type zebrafish. This study exhibits that among the three types of Kampo-hozai, Ninjinyoeito is the most effective in psychiatric disorders associated with anxiety and low sociability.

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Multiple stage IV colorectal cancers in a patient who received multidisciplinary treatment, including chemotherapy and Japanese Kampo medicine: A case report

Cited by 4 publications

References 27 publications

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Efficacy of Ninjin'yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit

Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish

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