Efficacy of Ninjin'yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit

Aomatsu, Naoki; Shigemitsu, Kazuaki; Nakagawa, Hidenori; Morooka, Takaya; Ishikawa, Junichi; Yamashita, Tomoya; Tsuruoka, Ayumu; Fuke, Akihiro; Motoyama, Koka; Kitagawa, Daiki; Ikeda, Katsumi; Maeda, Kiyoshi; Shirano, Michinori; Rinka, Hiroshi

doi:10.1016/j.npep.2021.102201

Cited by 5 publications

(1 citation statement)

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“…The effect of NYT use can be predicted based on previous research that has reported various beneficial effects of NYT. NYT is composed of 12 crude drugs, including Rehmannia root, Japanese angelica root, Atractylodes rhizome, peony root, cinnamon bark, astragalus root, poria sclerotium, Citrus unshiu peel, polygala root, Glycyrrhiza, and schisandra fruit, which have been the subject of previous studies that demonstrated its efficacy [13,[17][18][19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Ninjin’yoeito Improves Genitourinary Symptoms in Patients With Frailty

Okui¹,

Okui²

2023

Cureus

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Introduction In geriatric medicine, there is currently significant attention on frailty, a condition commonly associated with aging and characterized by muscle weakness and other age-related changes. Within the fields of urology and gynecology, conditions such as overactive bladder (OAB) and genitourinary syndrome of menopause (GSM) have been identified as crucial concerns due to their negative impact on the quality of life of elderly individuals. In this study, we investigated the potential of Ninjin'yoeito (NYT), a traditional Chinese herbal medicine, as a viable treatment option for frailty. Additionally, we hypothesized that NYT may also contribute to the improvement of symptoms associated with OAB and GSM, and potentially help in reducing the dosage of OAB medications. Methods In this retrospective cohort study conducted from November 2016 to November 2022, we created a website describing the relationship between frailty and genitourinary symptoms in frail patients aged ≥ 65 years with GSM who underwent pelvic floor muscle training. The patients were divided into two propensity score-matched groups: NYT group (received NYT for one year) and no-NYT group (did not receive NYT), based on their wishes. The fatigue, resistance, ambulation, illnesses, and loss of weight (FRAIL) scale was used to assess frailty status. Urinary symptoms were evaluated using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) and Overactive Bladder Symptom Score (OABSS). Genital symptoms were investigated using the vaginal health index score and vulvodynia swab test. The value of each score was obtained before (T0) and 12 months after (T12) treatment, and the difference (Δ T0/T12 ) was calculated. Results During the study period, 985 outpatients visited our clinic, of whom 725 were considered frail/pre-frail; 402 women with frailty/pre-frailty (mean age 77.5 ± 6.49 years) were included, with a median follow-up of 14.5 months. The NYT and no-NYT groups had 220 and 182 patients, respectively. After propensity score matching, each group had 159 patients. Δ T0/T12 FRAIL scale score was significantly higher in the NYT group (0.13 ± 0.37) than in the no-NYT (0.01 ± 0.10) group (p=0.001.) However, urinary symptoms improved in the NYT group more than in the no-NYT in terms of the following parameters: Δ T0/T12 OABSS (NYT: 0.89 ± 1.65; no-NYTl: 0.36 ± 1.14, p=0.001) and Δ T0/T12 ICIQ-SF score (NYT: 1.51 ± 1.75; no-NYT: 0.42 ± 1.18, p<0.001). Genital symptoms were better in the NYT group in terms of ΔT0/T12 VHIS (NYT: 0.58 ±1.08; no-NYT: 0.21 ±0.65, p<0.001). The vulvodynia swab test showed improvements in left para-hymen evoked pain in both groups. In the NYT group, 5% of the patients underwent antimuscarinic drug dose reduction for overactive bladder treatment. NYT use was not associated with significant side effects, and only 0.6% of pati...

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