Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil

Abstract

The chemical composition of Gallesia integrifolia fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Antiinflammatory activity that provides 50% inhibition of nitric oxide production (55 mg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI 50 ¼ 66 mg/mL), NCI-H-460 (GI 50 ¼ 147 mg/mL), HeLa (GI 50 ¼ 182 mg/mL) and HepG2 (GI 50 ¼ 240 mg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI 50 values for essential oil reported in our work support future studies.

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

“…These values were only 5.71 and 8.57 times less active than the dexamethasone positive control (EC 50 = 6.3 µg/mL). Bortolucci et al [10] also reported the anti-inflammatory potential of the EO from fruits (EC 50 = 55 µg/mL) collected from the same specimen of G. integrifolia used in our study. The presence of lenthionine (9.27%) and dimethyl trisulfide (19.40%) was observed in the EO of the fruits (Table 3).…”

“…Studies conducted with essential oils and extracts from this species indicate anti-inflammatory, antiproliferative and antitumor [ 10 ], antifungal [ 8 , 11 ], acaricidal and larvicidal potential against Rhipicephalus microplus [ 12 , 13 ], larvicidal against Aedes aegypt [ 14 ], antiviral [ 15 ], antimycobacterial [ 9 ], and antiulcer [ 16 ] properties.…”

“…Phytochemical analysis of crude extracts from flowers and fruits of G. integrifolia indicated high concentrations of vitamin C and organosulfur compounds, and in leaves, high concentrations of phytol, fatty acids, and fatty acid esters [ 10 ]. Oxygenated diterpenes were also found in flowers and leaves, as well as phytosterol and triterpenes in fruits [ 13 ].…”

INFLUÊNCIA DE FATORES ABIÓTICOS NO RENDIMENTO DO ÓLEO ESSENCIAL DA Gallesia integrifolia (SPRENG.) HARMS

“…A G. integrifolia é reconhecida como sendo de grande importância para área medicinal como antiinflamatória e capacidade antimicrobiana (ARUNACHALAM et al, 2016;BORTOLUCCI et al, 2021), além disso apresenta atividade contra larvas do Aedes aegypti e carrapato bovino (DIAS et al, 2018;RAIMUNDO et al, 2021). O OE dos frutos de G. integrifolia tem alta atividade fungicida conforme os resultados publicados por Raimundo et al (2018) podendo servir como aplicações futuras na redução do uso de fungicidas sintéticos.…”

“…O OE dos frutos de G. integrifolia tem alta atividade fungicida conforme os resultados publicados por Raimundo et al (2018) podendo servir como aplicações futuras na redução do uso de fungicidas sintéticos. Estudos realizados por Bortolucci et al, (2021), utilizando o OE dos frutos, indicaram atividade antiinflamatória e células antitumoral.…”